Abstract
Gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 background resulted in peri-implantation death due to degeneration of the inner cell mass. On a 129/Sv background, homozygous mutants died at mid-gestation due to placental defects; on a CD-1 background, the mutants lived for up to 3 weeks and showed abnormalities in skin, kidney, brain, liver, and gastrointestinal tract. The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities.
Original language | English (US) |
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Pages (from-to) | 230-234 |
Number of pages | 5 |
Journal | Science |
Volume | 269 |
Issue number | 5221 |
DOIs | |
State | Published - 1995 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- General