Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats

R. Craig Sanders, Thomas F. Murray

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The temporal requirements for theophylline-induced upregulation of A1 adenosine receptors and elevation of seizure threshold were examined. Chronic theophylline exposure (75 mg/kg twice daily) elicited a significant upregulation of [3H]cyclohexyladenosine ([3H]CHA) binding sites following 7 and 14 days of treatment. Alterations in seizure threshold followed a similar temporal pattern of development. The reversibility of theophylline-induced upregulation of high affinity [3H]CHA binding sites was complete at 10 days following cessation of theophylline administration, while the alteration of seizure threshold required 21 days to return to control values.

Original languageEnglish
Pages (from-to)325-330
Number of pages6
JournalNeuroscience Letters
Issue number3
Publication statusPublished - Jul 3 1989
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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