Abstract
The temporal requirements for theophylline-induced upregulation of A1 adenosine receptors and elevation of seizure threshold were examined. Chronic theophylline exposure (75 mg/kg twice daily) elicited a significant upregulation of [3H]cyclohexyladenosine ([3H]CHA) binding sites following 7 and 14 days of treatment. Alterations in seizure threshold followed a similar temporal pattern of development. The reversibility of theophylline-induced upregulation of high affinity [3H]CHA binding sites was complete at 10 days following cessation of theophylline administration, while the alteration of seizure threshold required 21 days to return to control values.
| Original language | English |
|---|---|
| Pages (from-to) | 325-330 |
| Number of pages | 6 |
| Journal | Neuroscience Letters |
| Volume | 101 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jul 3 1989 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
Cite this
Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats. / Craig Sanders, R.; Murray, Thomas F.
In: Neuroscience Letters, Vol. 101, No. 3, 03.07.1989, p. 325-330.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats
AU - Craig Sanders, R.
AU - Murray, Thomas F.
PY - 1989/7/3
Y1 - 1989/7/3
N2 - The temporal requirements for theophylline-induced upregulation of A1 adenosine receptors and elevation of seizure threshold were examined. Chronic theophylline exposure (75 mg/kg twice daily) elicited a significant upregulation of [3H]cyclohexyladenosine ([3H]CHA) binding sites following 7 and 14 days of treatment. Alterations in seizure threshold followed a similar temporal pattern of development. The reversibility of theophylline-induced upregulation of high affinity [3H]CHA binding sites was complete at 10 days following cessation of theophylline administration, while the alteration of seizure threshold required 21 days to return to control values.
AB - The temporal requirements for theophylline-induced upregulation of A1 adenosine receptors and elevation of seizure threshold were examined. Chronic theophylline exposure (75 mg/kg twice daily) elicited a significant upregulation of [3H]cyclohexyladenosine ([3H]CHA) binding sites following 7 and 14 days of treatment. Alterations in seizure threshold followed a similar temporal pattern of development. The reversibility of theophylline-induced upregulation of high affinity [3H]CHA binding sites was complete at 10 days following cessation of theophylline administration, while the alteration of seizure threshold required 21 days to return to control values.
UR - http://www.scopus.com/inward/record.url?scp=0024960499&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024960499&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(89)90554-5
DO - 10.1016/0304-3940(89)90554-5
M3 - Article
C2 - 2771176
AN - SCOPUS:0024960499
VL - 101
SP - 325
EP - 330
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -