Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats

R. Craig Sanders; Thomas F. Murray

doi:10.1016/0304-3940(89)90554-5

Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats

R. Craig Sanders, Thomas F. Murray

Research output: Contribution to journal › Article

23 Citations (Scopus)

Abstract

The temporal requirements for theophylline-induced upregulation of A₁ adenosine receptors and elevation of seizure threshold were examined. Chronic theophylline exposure (75 mg/kg twice daily) elicited a significant upregulation of [³H]cyclohexyladenosine ([³H]CHA) binding sites following 7 and 14 days of treatment. Alterations in seizure threshold followed a similar temporal pattern of development. The reversibility of theophylline-induced upregulation of high affinity [³H]CHA binding sites was complete at 10 days following cessation of theophylline administration, while the alteration of seizure threshold required 21 days to return to control values.

Original language	English
Pages (from-to)	325-330
Number of pages	6
Journal	Neuroscience Letters
Volume	101
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(89)90554-5
State	Published - Jul 3 1989
Externally published	Yes

Fingerprint

Adenosine A1 Receptors

Bicuculline

Theophylline

Seizures

Up-Regulation

Binding Sites

All Science Journal Classification (ASJC) codes

Neuroscience(all)

Cite this

Craig Sanders, R., & Murray, T. F. (1989). Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats. Neuroscience Letters, 101(3), 325-330. https://doi.org/10.1016/0304-3940(89)90554-5

Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats. / Craig Sanders, R.; Murray, Thomas F.

In: Neuroscience Letters, Vol. 101, No. 3, 03.07.1989, p. 325-330.

Research output: Contribution to journal › Article

Craig Sanders, R & Murray, TF 1989, 'Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats', Neuroscience Letters, vol. 101, no. 3, pp. 325-330. https://doi.org/10.1016/0304-3940(89)90554-5

Craig Sanders R, Murray TF. Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats. Neuroscience Letters. 1989 Jul 3;101(3):325-330. https://doi.org/10.1016/0304-3940(89)90554-5

Craig Sanders, R. ; Murray, Thomas F. / Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats. In: Neuroscience Letters. 1989 ; Vol. 101, No. 3. pp. 325-330.

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10.1016/0304-3940(89)90554-5