Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats

R. Craig Sanders, Thomas F. Murray

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The temporal requirements for theophylline-induced upregulation of A1 adenosine receptors and elevation of seizure threshold were examined. Chronic theophylline exposure (75 mg/kg twice daily) elicited a significant upregulation of [3H]cyclohexyladenosine ([3H]CHA) binding sites following 7 and 14 days of treatment. Alterations in seizure threshold followed a similar temporal pattern of development. The reversibility of theophylline-induced upregulation of high affinity [3H]CHA binding sites was complete at 10 days following cessation of theophylline administration, while the alteration of seizure threshold required 21 days to return to control values.

Original languageEnglish (US)
Pages (from-to)325-330
Number of pages6
JournalNeuroscience Letters
Volume101
Issue number3
DOIs
StatePublished - Jul 3 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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