Abstract
Thalassemia refers to a syndrome of diseases characterized by decreased or absent production of one or more globin chains. Beta thalassemia is due to deficient production of beta globin chains, which causes a relative excess of alpha globin chains. These excess alpha globin chains are insoluble and precipitate within the red cell, leading to a variety of clinical manifestations.The severity of subsequent clinical manifestations depends on the degree of alpha globin chain excess. The symptoms are severe in patients homozygous for impaired beta globin synthesis and much less severe in heterozygotes, who generally have mild anemia and no symptoms. Alpha thalassemia is due to decreased production of alpha globin chains, resulting in a relative excess of beta globin chains.© 2008
| Original language | English |
|---|---|
| Title of host publication | xPharm: The Comprehensive Pharmacology Reference |
| Publisher | Elsevier Inc. |
| Pages | 1-6 |
| Number of pages | 6 |
| ISBN (Print) | 9780080552323 |
| DOIs | |
| State | Published - 2011 |
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All Science Journal Classification (ASJC) codes
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Thalassemia. / Silberstein, Peter T.
xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., 2011. p. 1-6.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Thalassemia
AU - Silberstein, Peter T.
PY - 2011
Y1 - 2011
N2 - Thalassemia refers to a syndrome of diseases characterized by decreased or absent production of one or more globin chains. Beta thalassemia is due to deficient production of beta globin chains, which causes a relative excess of alpha globin chains. These excess alpha globin chains are insoluble and precipitate within the red cell, leading to a variety of clinical manifestations.The severity of subsequent clinical manifestations depends on the degree of alpha globin chain excess. The symptoms are severe in patients homozygous for impaired beta globin synthesis and much less severe in heterozygotes, who generally have mild anemia and no symptoms. Alpha thalassemia is due to decreased production of alpha globin chains, resulting in a relative excess of beta globin chains.© 2008
AB - Thalassemia refers to a syndrome of diseases characterized by decreased or absent production of one or more globin chains. Beta thalassemia is due to deficient production of beta globin chains, which causes a relative excess of alpha globin chains. These excess alpha globin chains are insoluble and precipitate within the red cell, leading to a variety of clinical manifestations.The severity of subsequent clinical manifestations depends on the degree of alpha globin chain excess. The symptoms are severe in patients homozygous for impaired beta globin synthesis and much less severe in heterozygotes, who generally have mild anemia and no symptoms. Alpha thalassemia is due to decreased production of alpha globin chains, resulting in a relative excess of beta globin chains.© 2008
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U2 - 10.1016/B978-008055232-3.64062-0
DO - 10.1016/B978-008055232-3.64062-0
M3 - Chapter
SN - 9780080552323
SP - 1
EP - 6
BT - xPharm: The Comprehensive Pharmacology Reference
PB - Elsevier Inc.
ER -