Thalassemia minor

a risk factor for osteoporosis?

Nancy Greep, Anne Line J Anderson, John Christopher G. Gallagher

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A case report of a 53 year old postmenopausal woman with severe osteoporosis occurring in association with beta thalassemia trait is presented. She was found to have marked axial osteopenia with lumbar spine bone mineral density that was more than three standard deviations below the mean, but had normal bone mineral density of the proximal radius. A biopsy of the iliac crest showed evidence of high turnover osteoporosis. Bone densitometry of the spine and hip in a consecutive series of eleven asymptomatic individuals with thalassemia trait also is reported. Bone mineral density was diminished in the spine (z-score = -0.78, P <0.03) and hip (z score = -0.54, P = 0.05) of patients with thalassemia trait. It is postulated that thalassemia minor may be a risk factor for osteoporosis.

Original languageEnglish
Pages (from-to)63-72
Number of pages10
JournalBone and Mineral
Volume16
Issue number1
DOIs
StatePublished - 1992

Fingerprint

beta-Thalassemia
Bone Density
Osteoporosis
Bone
Spine
Thalassemia
Minerals
Hip
Densitometry
Metabolic Bone Diseases
Biopsy
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology
  • Surgery

Cite this

Thalassemia minor : a risk factor for osteoporosis? / Greep, Nancy; Anderson, Anne Line J; Gallagher, John Christopher G.

In: Bone and Mineral, Vol. 16, No. 1, 1992, p. 63-72.

Research output: Contribution to journalArticle

Greep, Nancy ; Anderson, Anne Line J ; Gallagher, John Christopher G. / Thalassemia minor : a risk factor for osteoporosis?. In: Bone and Mineral. 1992 ; Vol. 16, No. 1. pp. 63-72.
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