Abstract
The purpose of this study was to identify the genetic organization and inducibility of blaACT-1 in a clinical isolate of Klebsiella pneumoniae possessing at least five different β-lactamases. The genetic organization of the blaACT-1lampR region is identical to those of inducible chromosomal ampC genes. RNA analysis using primer extension demonstrated a five-fold increase in blaACT-1 transcript production on exposure to cefoxitin. These findings are significant because induction was detected in a complicated β-lactamase background. In addition, this report is the first to describe an inducible plasmid-encoded AmpC β-lactamase of Enterobacter cloacae origin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 557-560 |
| Number of pages | 4 |
| Journal | Journal of Antimicrobial Chemotherapy |
| Volume | 49 |
| Issue number | 3 |
| State | Published - 2002 |
All Science Journal Classification (ASJC) codes
- Pharmacology
- Microbiology (medical)
- Infectious Diseases
- Pharmacology (medical)