The adverse pharmacology of calcineurin inhibitors and their impact on hepatitis C recurrence after liver transplantation: Implications for clinical practice

Mauricio Garcia-Saenz-De-Sicilia, Sandeep Mukherjee

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Calcineurin inhibitors are widely used as maintenance immunosuppressants in solid-organ transplantation to minimize the risk of allograft rejection. Although the use of these agents has transformed the outcomes for patient and graft survival, this has come at a cost, notably the well-known adverse events of nephrotoxicity and metabolic abnormalities, to name a few. Over the last decade, tremendous interest has also focused on the impact of these medications on the replication of hepatitis C virus (HCV), with cyclosporine in particular having a negative effect on viral replication in vitro. Although small retrospective studies suggested that there may be a beneficial effect with cyclosporine on the progression of recurrent HCV and response to interferon, these findings have not been validated in several well-designed randomized controlled trial studies. The authors will review the pharmacology and pharmacokinetics of these well-known drugs and discuss the impact of these medications on the natural history of HCV recurrence after liver transplantation.

Original languageEnglish (US)
Pages (from-to)587-593
Number of pages7
JournalExpert Review of Clinical Pharmacology
Volume5
Issue number5
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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