Abstract
Tobacco smoke is an established carcinogen, but the association between tobacco smoking and cancer risk in BRCA mutation carriers is not clear. The aim of this study was to evaluate prospectively the association between tobacco smoking and cancer incidence in a cohort of BRCA1 and BRCA2 mutation carriers. The study population consisted of unaffected BRCA mutation carriers. Information on lifestyle including smoking histories, reproductive factors, and past medical histories was obtained through questionnaires. Incident cancers were updated biennially via follow-up questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using time-dependent Cox regression models. There were 700 incident cancers diagnosed over 26,711 person-years of follow-up. The most frequent cancers seen in BRCA mutation carriers were breast (n = 428; 61%) and ovarian (n = 109; 15%) cancer. Compared to nonsmokers, (ever) smoking was associated with a modest increased risk of all cancers combined (HR = 1.17; 95%CI 1.01–1.37). Women in the highest group of total pack-years (4.3–9.8) had an increased risk of developing any cancer (HR = 1.27; 95%CI 1.04–1.56), breast cancer (HR = 1.33, 95%CI 1.02–1.75), and ovarian cancer (HR = 1.68; 95%CI 1.06–2.67) compared to never smokers. The associations between tobacco smoking and cancer did not differ by BRCA mutation type or by age at diagnosis. This prospective study suggests that tobacco smoking is associated with a modest increase in the risks of breast and ovarian cancer among women with BRCA1 or BRCA2 mutation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2263-2272 |
| Number of pages | 10 |
| Journal | International Journal of Cancer |
| Volume | 142 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jun 1 2018 |
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All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
Cite this
The association between smoking and cancer incidence in BRCA1 and BRCA2 mutation carriers. / the Hereditary Breast Cancer Clinical Study Group.
In: International Journal of Cancer, Vol. 142, No. 11, 01.06.2018, p. 2263-2272.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The association between smoking and cancer incidence in BRCA1 and BRCA2 mutation carriers
AU - the Hereditary Breast Cancer Clinical Study Group
AU - Ko, Kwang Pil
AU - Kim, Shana J.
AU - Huzarski, Tomasz
AU - Gronwald, Jacek
AU - Lubinski, Jan
AU - Lynch, Henry T.
AU - Armel, Susan
AU - Park, Sue K.
AU - Karlan, Beth
AU - Singer, Christian F.
AU - Neuhausen, Susan L.
AU - Narod, Steven A.
AU - Kotsopoulos, Joanne
AU - Snyder, Carrie
AU - Meschino, Wendy
AU - Demsky, Rochelle
AU - Ainsworth, Peter
AU - Panabaker, Karen
AU - Taylor, Melanie
AU - Couch, Fergus
AU - Manoukian, Siranoush
AU - Rappaport, Christine
AU - Pasini, Barbara
AU - Daly, Mary B.
AU - Olopade, Olufunmilayo
AU - Steele, Linda
AU - Saal, Howard
AU - Fallen, Taya
AU - Wood, Marie
AU - McKinnon, Wendy
AU - Lemire, Edmond
AU - Chudley, Albert E.
AU - Serfas, Kim
AU - Sweet, Kevin
AU - Bordeleau, Louise
AU - Elser, Christine
AU - Panchal, Seema
AU - Zakalik, Dana
AU - Vadaparampil, Susan T.
AU - Ginsburg, Ophira
AU - Hurst, Stephanie
AU - Cullinane, Carey A.
AU - Reilly, Robert E.
AU - Blum, Joanne L.
AU - Ross, Theodora
AU - Mauer, Caitlin
AU - Kwong, Ava
AU - Cybulski, Cezary
AU - McCuaig, Jeanna
AU - Merajver, Sofia
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Tobacco smoke is an established carcinogen, but the association between tobacco smoking and cancer risk in BRCA mutation carriers is not clear. The aim of this study was to evaluate prospectively the association between tobacco smoking and cancer incidence in a cohort of BRCA1 and BRCA2 mutation carriers. The study population consisted of unaffected BRCA mutation carriers. Information on lifestyle including smoking histories, reproductive factors, and past medical histories was obtained through questionnaires. Incident cancers were updated biennially via follow-up questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using time-dependent Cox regression models. There were 700 incident cancers diagnosed over 26,711 person-years of follow-up. The most frequent cancers seen in BRCA mutation carriers were breast (n = 428; 61%) and ovarian (n = 109; 15%) cancer. Compared to nonsmokers, (ever) smoking was associated with a modest increased risk of all cancers combined (HR = 1.17; 95%CI 1.01–1.37). Women in the highest group of total pack-years (4.3–9.8) had an increased risk of developing any cancer (HR = 1.27; 95%CI 1.04–1.56), breast cancer (HR = 1.33, 95%CI 1.02–1.75), and ovarian cancer (HR = 1.68; 95%CI 1.06–2.67) compared to never smokers. The associations between tobacco smoking and cancer did not differ by BRCA mutation type or by age at diagnosis. This prospective study suggests that tobacco smoking is associated with a modest increase in the risks of breast and ovarian cancer among women with BRCA1 or BRCA2 mutation.
AB - Tobacco smoke is an established carcinogen, but the association between tobacco smoking and cancer risk in BRCA mutation carriers is not clear. The aim of this study was to evaluate prospectively the association between tobacco smoking and cancer incidence in a cohort of BRCA1 and BRCA2 mutation carriers. The study population consisted of unaffected BRCA mutation carriers. Information on lifestyle including smoking histories, reproductive factors, and past medical histories was obtained through questionnaires. Incident cancers were updated biennially via follow-up questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using time-dependent Cox regression models. There were 700 incident cancers diagnosed over 26,711 person-years of follow-up. The most frequent cancers seen in BRCA mutation carriers were breast (n = 428; 61%) and ovarian (n = 109; 15%) cancer. Compared to nonsmokers, (ever) smoking was associated with a modest increased risk of all cancers combined (HR = 1.17; 95%CI 1.01–1.37). Women in the highest group of total pack-years (4.3–9.8) had an increased risk of developing any cancer (HR = 1.27; 95%CI 1.04–1.56), breast cancer (HR = 1.33, 95%CI 1.02–1.75), and ovarian cancer (HR = 1.68; 95%CI 1.06–2.67) compared to never smokers. The associations between tobacco smoking and cancer did not differ by BRCA mutation type or by age at diagnosis. This prospective study suggests that tobacco smoking is associated with a modest increase in the risks of breast and ovarian cancer among women with BRCA1 or BRCA2 mutation.
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UR - http://www.scopus.com/inward/citedby.url?scp=85045249324&partnerID=8YFLogxK
U2 - 10.1002/ijc.31257
DO - 10.1002/ijc.31257
M3 - Article
C2 - 29330845
AN - SCOPUS:85045249324
VL - 142
SP - 2263
EP - 2272
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 11
ER -