The association of bone mineral density with vitamin D receptor gene polymorphisms

G. Gong, H. S. Stern, Shih-Chuan Cheng, N. Fong, J. Mordeson, H. W. Deng, Robert R. Recker

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Abstract

A recent meta-analysis of 16 publications suggested that bone mineral density (BMD) is not polymorphism (VDRGP) at the 0.05 significance level when a study with genotyping mistakes is excluded. We wished to determine whether 'positive' findings supporting the BMD-VDRGP association may be explained by chance, and what factors affect the outcomes of these studies. Seventy-five articles and abstracts on the association of VDRGP with BMD and related skeletal phenotypes published before January 1997 were identified. Twenty-three of 67 (34.3%) studies on spinal BMD and 22 of 51 (43.1%) on femoral neck BMD had found a BMD-VDRGP association at p <0.05, significantly (p = 7 x 10-14 for spinal BMD, p = 9 x 10-16 for hip BMD) higher than the expected 5% false positive rate under the null hypothesis of 'no association'. 'Positive' results were more frequently observed in studies on females before the menopause than those on females after the menopause (p <0.02) or on male and female subjects combined (p <0.05) when skeletal phenotypes at any bone sites were considered. The 'positive rate' among studies was also influenced by the age range of subjects studied and by the inclusion of subjects with osteoporosis. It is concluded that: (1) BMD is associated with VDRGP with high levels of confidence and (2) non-genetic factors and genetic heterogeneity interfere with the detection of the effects of VDRGP on bone phenotypes.

Original languageEnglish
Pages (from-to)55-64
Number of pages10
JournalOsteoporosis International
Volume9
Issue number1
DOIs
StatePublished - 1999

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Calcitriol Receptors
Bone Density
Genes
Menopause
Phenotype
Pelvic Bones
Bone and Bones
Genetic Heterogeneity
Femur Neck
Osteoporosis
Publications
Meta-Analysis
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

The association of bone mineral density with vitamin D receptor gene polymorphisms. / Gong, G.; Stern, H. S.; Cheng, Shih-Chuan; Fong, N.; Mordeson, J.; Deng, H. W.; Recker, Robert R.

In: Osteoporosis International, Vol. 9, No. 1, 1999, p. 55-64.

Research output: Contribution to journalArticle

Gong, G. ; Stern, H. S. ; Cheng, Shih-Chuan ; Fong, N. ; Mordeson, J. ; Deng, H. W. ; Recker, Robert R. / The association of bone mineral density with vitamin D receptor gene polymorphisms. In: Osteoporosis International. 1999 ; Vol. 9, No. 1. pp. 55-64.
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