The bone-remodeling transient: Implications for the interpretation of clinical studies of bone mass change

Robert P. Heaney

Research output: Contribution to journalArticle

214 Citations (Scopus)

Abstract

A computer simulation of the bone-remodeling transient is described, in which the focus is explicitly on changes in clinically measurable bone mass (or density). Based upon quantitative remodeling data accumulated by histomorphometry and calcium tracer kinetics, the simulation shows that much of the apparent gain in bone produced by several agents currently employed to treat osteoporosis can be explained as a remodeling transient rather than as a fundamental alteration of remodeling balance. Even gains as large as 30% or more can be produced by nothing more than the remodeling transient under certain plausible combinations of basal remodeling rate, remodeling period, and degree of bone loss. The simulation further highlights the importance, in evaluating bone-active agents, of separating the response across the first remodeling period from bone changes that may ensue thereafter.

Original languageEnglish
Pages (from-to)1515-1523
Number of pages9
JournalJournal of Bone and Mineral Research
Volume9
Issue number10
StatePublished - Oct 1994

Fingerprint

Bone Remodeling
Bone and Bones
Computer Simulation
Osteoporosis
Calcium
Clinical Studies

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

The bone-remodeling transient : Implications for the interpretation of clinical studies of bone mass change. / Heaney, Robert P.

In: Journal of Bone and Mineral Research, Vol. 9, No. 10, 10.1994, p. 1515-1523.

Research output: Contribution to journalArticle

@article{ddc2c342657e44b4b5f7846e3a1ef9fe,
title = "The bone-remodeling transient: Implications for the interpretation of clinical studies of bone mass change",
abstract = "A computer simulation of the bone-remodeling transient is described, in which the focus is explicitly on changes in clinically measurable bone mass (or density). Based upon quantitative remodeling data accumulated by histomorphometry and calcium tracer kinetics, the simulation shows that much of the apparent gain in bone produced by several agents currently employed to treat osteoporosis can be explained as a remodeling transient rather than as a fundamental alteration of remodeling balance. Even gains as large as 30{\%} or more can be produced by nothing more than the remodeling transient under certain plausible combinations of basal remodeling rate, remodeling period, and degree of bone loss. The simulation further highlights the importance, in evaluating bone-active agents, of separating the response across the first remodeling period from bone changes that may ensue thereafter.",
author = "Heaney, {Robert P.}",
year = "1994",
month = "10",
language = "English",
volume = "9",
pages = "1515--1523",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - The bone-remodeling transient

T2 - Implications for the interpretation of clinical studies of bone mass change

AU - Heaney, Robert P.

PY - 1994/10

Y1 - 1994/10

N2 - A computer simulation of the bone-remodeling transient is described, in which the focus is explicitly on changes in clinically measurable bone mass (or density). Based upon quantitative remodeling data accumulated by histomorphometry and calcium tracer kinetics, the simulation shows that much of the apparent gain in bone produced by several agents currently employed to treat osteoporosis can be explained as a remodeling transient rather than as a fundamental alteration of remodeling balance. Even gains as large as 30% or more can be produced by nothing more than the remodeling transient under certain plausible combinations of basal remodeling rate, remodeling period, and degree of bone loss. The simulation further highlights the importance, in evaluating bone-active agents, of separating the response across the first remodeling period from bone changes that may ensue thereafter.

AB - A computer simulation of the bone-remodeling transient is described, in which the focus is explicitly on changes in clinically measurable bone mass (or density). Based upon quantitative remodeling data accumulated by histomorphometry and calcium tracer kinetics, the simulation shows that much of the apparent gain in bone produced by several agents currently employed to treat osteoporosis can be explained as a remodeling transient rather than as a fundamental alteration of remodeling balance. Even gains as large as 30% or more can be produced by nothing more than the remodeling transient under certain plausible combinations of basal remodeling rate, remodeling period, and degree of bone loss. The simulation further highlights the importance, in evaluating bone-active agents, of separating the response across the first remodeling period from bone changes that may ensue thereafter.

UR - http://www.scopus.com/inward/record.url?scp=0027939940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027939940&partnerID=8YFLogxK

M3 - Article

C2 - 7817796

AN - SCOPUS:0027939940

VL - 9

SP - 1515

EP - 1523

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 10

ER -