The c-Fes family of protein-tyrosine kinases

Thomas E. Smithgall, Jim A. Rogers, Kristi L. Peters, Jianze Li, Scott D. Briggs, Jack M. Lionberger, Haiyun Cheng, Annemarie Shibata, Beate Scholtz, Steven Schreiner, Nancy Dunham

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Abstract

The human c-fes protooncogene encodes a protein-tyrosine kinase (c-Fes) distinct from c-Src, cAbl and other nonreceptor tyrosine kinases. Although originally identified as the cellular homolog of several transforming retroviral oncoproteins, Fes was later found to exhibit strong expression in myeloid hematopoietic cells and to play a direct role in their differentiation. Recent work has shown that Fes exhibits a more widespread expression pattern in both developing and adult tissues, suggesting a general physiological function for this kinase and its closely related homolog, Fer. This review highlights the unique aspects of Fes structure, regulation, and function that set it apart from other tyrosine kinase families.

Original languageEnglish
Pages (from-to)43-62
Number of pages20
JournalCritical Reviews in Oncogenesis
Volume9
Issue number1
Publication statusPublished - 1998
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Cancer Research

Cite this

Smithgall, T. E., Rogers, J. A., Peters, K. L., Li, J., Briggs, S. D., Lionberger, J. M., ... Dunham, N. (1998). The c-Fes family of protein-tyrosine kinases. Critical Reviews in Oncogenesis, 9(1), 43-62.