The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females

Fang Yang, Dong Hai Xiong, Yan Guo, Hui Shen, Peng Xiao, Feng Zhang, Hui Jiang, Robert R. Recker, Hong Wen Deng

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Abstract

Chemokine (C-C-motif) receptor 3 (CCR3), playing an important role in endometrium related metabolic pathways, may influence the onset of menarche. To test linkage and/or association between CCR3 polymorphisms with the variation of age at menarche (AAM) in Caucasian females, we recruited a sample of 1,048 females from 354 Caucasian nuclear families and genotyped 16 SNPs spanning the entire CCR3 gene. Linkage disequilibrium and haplotype blocks were inferred by Haploview. Both single-SNP markers and haplotypes were tested for linkage and/or association with AAM using QTDT (quantitative transmission disequilibrium test). We also tested associations between CCR3 polymorphisms and AAM in a selected random sample of daughters using ANOVA (analysis of variance). We identified two haplotype blocks. Only block two showed significant results. After correction for multiple testing, significant total associations of SNP7, SNP9 with AAM were detected (P = 0.009 and 0.006, respectively). We also detected significant within-family association of SNP9 (P = 0.01). SNP14 was linked to AAM (P = 0.02) at the nominal level. In addition, there was evidence of significant total association and nominal significant linkage (P = 0.008 and 0.03, respectively) with AAM for the haplotype AGA reconstructed by SNP7, SNP9 and SNP13. ANOVA confirmed the results by QTDT. For the first time we reported that CCR3 is linked and associated with AAM variation in Caucasian women. However, further studies are necessary to substantiate our conclusions.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalHuman Genetics
Volume121
Issue number1
DOIs
StatePublished - Mar 2007

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CXCR3 Receptors
Menarche
Haplotypes
Genes
Nuclear Family
Single Nucleotide Polymorphism
Analysis of Variance
Linkage Disequilibrium
Endometrium
Metabolic Networks and Pathways

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Genetics

Cite this

The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females. / Yang, Fang; Xiong, Dong Hai; Guo, Yan; Shen, Hui; Xiao, Peng; Zhang, Feng; Jiang, Hui; Recker, Robert R.; Deng, Hong Wen.

In: Human Genetics, Vol. 121, No. 1, 03.2007, p. 35-42.

Research output: Contribution to journalArticle

Yang, Fang ; Xiong, Dong Hai ; Guo, Yan ; Shen, Hui ; Xiao, Peng ; Zhang, Feng ; Jiang, Hui ; Recker, Robert R. ; Deng, Hong Wen. / The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females. In: Human Genetics. 2007 ; Vol. 121, No. 1. pp. 35-42.
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abstract = "Chemokine (C-C-motif) receptor 3 (CCR3), playing an important role in endometrium related metabolic pathways, may influence the onset of menarche. To test linkage and/or association between CCR3 polymorphisms with the variation of age at menarche (AAM) in Caucasian females, we recruited a sample of 1,048 females from 354 Caucasian nuclear families and genotyped 16 SNPs spanning the entire CCR3 gene. Linkage disequilibrium and haplotype blocks were inferred by Haploview. Both single-SNP markers and haplotypes were tested for linkage and/or association with AAM using QTDT (quantitative transmission disequilibrium test). We also tested associations between CCR3 polymorphisms and AAM in a selected random sample of daughters using ANOVA (analysis of variance). We identified two haplotype blocks. Only block two showed significant results. After correction for multiple testing, significant total associations of SNP7, SNP9 with AAM were detected (P = 0.009 and 0.006, respectively). We also detected significant within-family association of SNP9 (P = 0.01). SNP14 was linked to AAM (P = 0.02) at the nominal level. In addition, there was evidence of significant total association and nominal significant linkage (P = 0.008 and 0.03, respectively) with AAM for the haplotype AGA reconstructed by SNP7, SNP9 and SNP13. ANOVA confirmed the results by QTDT. For the first time we reported that CCR3 is linked and associated with AAM variation in Caucasian women. However, further studies are necessary to substantiate our conclusions.",
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