TY - JOUR
T1 - The clinical efficacy of deproteinized bovine bone mineral with 10% collagen in conjunction with localized piezosurgical decortication enhanced orthodontics
T2 - A prospective observational study
AU - Miyamoto, Takanari
AU - Lang, Melissa
AU - Khan, Shakeel
AU - Kumagai, Kota
AU - Nunn, Martha E.
N1 - Funding Information:
The authors would like to acknowledge Dr. Lane Harris (LH) for his technical assistance with the measurements of data. We also thank John Spitznagel, DDS, PhD, CEO of Science River Biomedical Consulting Services, for assistance with organization and proofreading the manuscript. This study was supported by a grant from the Geistlich Pharma, Wolhusen, Switzerland. All authors report no conflicts of interest related to this study. Bio‐Oss Collagen, Geistlich Pharma, Wolhusen, Switzerland. Invisalign, Align Technology, San Josè, CA. Variosurg, NSK, Tokyo, Japan. Ethicon, Inc., Johnson & Johnson, Cincinnati, OH.
Publisher Copyright:
© 2019 American Academy of Periodontology
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Background: Evidence exists on the clinical efficacy and safety of periodontally accelerated osteogenic orthodontics (PAOO) with “Piezocision”—a minimally invasive, flapless alternative to corticotomy for alveolar bone augmentation. Allograft has been extensively studied for alveolar bone augmentation in Piezocision; however, the use of deproteinized bovine bone mineral with 10% collagen (DBBM-C) in Piezocision for PAOO has not been investigated. Methods: This study is a prospective, observational, cohort study of 19 patients of Angle Class I malocclusion with a total of 692 teeth assessed for maintenance of health of the periodontal attachment apparatus. Patient-centered pain, sensitivity, and satisfaction outcomes, digital photographs and radiographs, and changes in probing depth, clinical attachment level, width of keratinized tissue, percussion sensitivity, pulp vitality tests, radiographic pathology, and root-crown-ratio were all recorded. Results: Overall treatment was significantly faster (5 to 7 days between clear aligner tray changes), periodontal parameters remained stable, and alveolar bone loss was not observed. Visual analog score for healing, sensitivity/duration, bleeding/duration, swelling/duration, appearance, and inflammation, demonstrated no significant differences between DBBM-C and control (no bone graft) groups. Patient-centered outcomes revealed high levels of satisfaction with Piezocision. Piezocision-treated teeth with DBBM-C tended to exhibit less root resorption, although it was not statistically significant (P = 0.074). Conclusions: Within the limits of the study, our results show that the use of DBBM-C with piezosurgically enhanced orthodontics is effective and safe. This study was not designed to demonstrate equivalence with other materials that might be used in Piezocision. To understand whether there is an advantage to using DBBM-C, additional studies may be required.
AB - Background: Evidence exists on the clinical efficacy and safety of periodontally accelerated osteogenic orthodontics (PAOO) with “Piezocision”—a minimally invasive, flapless alternative to corticotomy for alveolar bone augmentation. Allograft has been extensively studied for alveolar bone augmentation in Piezocision; however, the use of deproteinized bovine bone mineral with 10% collagen (DBBM-C) in Piezocision for PAOO has not been investigated. Methods: This study is a prospective, observational, cohort study of 19 patients of Angle Class I malocclusion with a total of 692 teeth assessed for maintenance of health of the periodontal attachment apparatus. Patient-centered pain, sensitivity, and satisfaction outcomes, digital photographs and radiographs, and changes in probing depth, clinical attachment level, width of keratinized tissue, percussion sensitivity, pulp vitality tests, radiographic pathology, and root-crown-ratio were all recorded. Results: Overall treatment was significantly faster (5 to 7 days between clear aligner tray changes), periodontal parameters remained stable, and alveolar bone loss was not observed. Visual analog score for healing, sensitivity/duration, bleeding/duration, swelling/duration, appearance, and inflammation, demonstrated no significant differences between DBBM-C and control (no bone graft) groups. Patient-centered outcomes revealed high levels of satisfaction with Piezocision. Piezocision-treated teeth with DBBM-C tended to exhibit less root resorption, although it was not statistically significant (P = 0.074). Conclusions: Within the limits of the study, our results show that the use of DBBM-C with piezosurgically enhanced orthodontics is effective and safe. This study was not designed to demonstrate equivalence with other materials that might be used in Piezocision. To understand whether there is an advantage to using DBBM-C, additional studies may be required.
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U2 - 10.1002/JPER.18-0737
DO - 10.1002/JPER.18-0737
M3 - Article
C2 - 30924533
AN - SCOPUS:85073183527
VL - 90
SP - 1106
EP - 1115
JO - Journal of Periodontology
JF - Journal of Periodontology
SN - 0022-3492
IS - 10
ER -