The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers

Joanne Kotsopoulos, Parviz Ghadirian, Ahmed El-Sohemy, Henry T. Lynch, Carrie Snyder, Mary Daly, Susan Domchek, Susan Randall, Beth Karlan, Phil Zhang, Shiyu Zhang, Ping Sun, Steven A. Narod

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

We have recently reported that, among BRCA1 mutation carriers, the consumption of caffeinated coffee was associated with a significant reduction in breast cancer risk. Because the metabolism of caffeine is primarily by CYP1A2, we examined whether or not the CYP1A2 genotype modifies the association between a history of coffee consumption and the risk of breast cancer. A common A to C polymorphism in the CYP1A2 gene is associated with decreased enzyme inducibility and impaired caffeine metabolism. Information regarding coffee consumption habits and the CYP1A2 genotype was available for 411 BRCA1 mutation carriers (170 cases and 241 controls). We estimated the odds ratios (ORs) and 95% confidence intervals (95% CIs) for breast cancer associated with the CYP1A2 genotype and a history of coffee consumption before age 35, adjusting for potential confounders. The CYP1A2 genotype did not affect breast cancer risk. Among women with at least one variant C allele (AC or CC), those who consumed coffee had a 64% reduction in breast cancer risk, compared with women who never consumed coffee (OR, 0.36; 95% CI, 0.18-0.73). A significant protective effect of coffee consumption was not observed among women with the CYP1A2 AA genotype (OR, 0.93; 95% CI, 0.49-1.77). Similar results were obtained when the analysis was restricted to caffeinated coffee. This study suggests that caffeine protects against breast cancer in women with a BRCA1 mutation and illustrates the importance of integrating individual genetic variability when assessing diet-disease associations.

Original languageEnglish
Pages (from-to)912-916
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume16
Issue number5
DOIs
StatePublished - May 2007

Fingerprint

Cytochrome P-450 CYP1A2
Coffee
Genotype
Breast Neoplasms
Mutation
Caffeine
Odds Ratio
Confidence Intervals
Habits
Alleles
Diet
Enzymes

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers. / Kotsopoulos, Joanne; Ghadirian, Parviz; El-Sohemy, Ahmed; Lynch, Henry T.; Snyder, Carrie; Daly, Mary; Domchek, Susan; Randall, Susan; Karlan, Beth; Zhang, Phil; Zhang, Shiyu; Sun, Ping; Narod, Steven A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 16, No. 5, 05.2007, p. 912-916.

Research output: Contribution to journalArticle

Kotsopoulos, J, Ghadirian, P, El-Sohemy, A, Lynch, HT, Snyder, C, Daly, M, Domchek, S, Randall, S, Karlan, B, Zhang, P, Zhang, S, Sun, P & Narod, SA 2007, 'The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers', Cancer Epidemiology Biomarkers and Prevention, vol. 16, no. 5, pp. 912-916. https://doi.org/10.1158/1055-9965.EPI-06-1074
Kotsopoulos, Joanne ; Ghadirian, Parviz ; El-Sohemy, Ahmed ; Lynch, Henry T. ; Snyder, Carrie ; Daly, Mary ; Domchek, Susan ; Randall, Susan ; Karlan, Beth ; Zhang, Phil ; Zhang, Shiyu ; Sun, Ping ; Narod, Steven A. / The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers. In: Cancer Epidemiology Biomarkers and Prevention. 2007 ; Vol. 16, No. 5. pp. 912-916.
@article{9d0e867635364853a159c42187b82817,
title = "The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers",
abstract = "We have recently reported that, among BRCA1 mutation carriers, the consumption of caffeinated coffee was associated with a significant reduction in breast cancer risk. Because the metabolism of caffeine is primarily by CYP1A2, we examined whether or not the CYP1A2 genotype modifies the association between a history of coffee consumption and the risk of breast cancer. A common A to C polymorphism in the CYP1A2 gene is associated with decreased enzyme inducibility and impaired caffeine metabolism. Information regarding coffee consumption habits and the CYP1A2 genotype was available for 411 BRCA1 mutation carriers (170 cases and 241 controls). We estimated the odds ratios (ORs) and 95{\%} confidence intervals (95{\%} CIs) for breast cancer associated with the CYP1A2 genotype and a history of coffee consumption before age 35, adjusting for potential confounders. The CYP1A2 genotype did not affect breast cancer risk. Among women with at least one variant C allele (AC or CC), those who consumed coffee had a 64{\%} reduction in breast cancer risk, compared with women who never consumed coffee (OR, 0.36; 95{\%} CI, 0.18-0.73). A significant protective effect of coffee consumption was not observed among women with the CYP1A2 AA genotype (OR, 0.93; 95{\%} CI, 0.49-1.77). Similar results were obtained when the analysis was restricted to caffeinated coffee. This study suggests that caffeine protects against breast cancer in women with a BRCA1 mutation and illustrates the importance of integrating individual genetic variability when assessing diet-disease associations.",
author = "Joanne Kotsopoulos and Parviz Ghadirian and Ahmed El-Sohemy and Lynch, {Henry T.} and Carrie Snyder and Mary Daly and Susan Domchek and Susan Randall and Beth Karlan and Phil Zhang and Shiyu Zhang and Ping Sun and Narod, {Steven A.}",
year = "2007",
month = "5",
doi = "10.1158/1055-9965.EPI-06-1074",
language = "English",
volume = "16",
pages = "912--916",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "5",

}

TY - JOUR

T1 - The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers

AU - Kotsopoulos, Joanne

AU - Ghadirian, Parviz

AU - El-Sohemy, Ahmed

AU - Lynch, Henry T.

AU - Snyder, Carrie

AU - Daly, Mary

AU - Domchek, Susan

AU - Randall, Susan

AU - Karlan, Beth

AU - Zhang, Phil

AU - Zhang, Shiyu

AU - Sun, Ping

AU - Narod, Steven A.

PY - 2007/5

Y1 - 2007/5

N2 - We have recently reported that, among BRCA1 mutation carriers, the consumption of caffeinated coffee was associated with a significant reduction in breast cancer risk. Because the metabolism of caffeine is primarily by CYP1A2, we examined whether or not the CYP1A2 genotype modifies the association between a history of coffee consumption and the risk of breast cancer. A common A to C polymorphism in the CYP1A2 gene is associated with decreased enzyme inducibility and impaired caffeine metabolism. Information regarding coffee consumption habits and the CYP1A2 genotype was available for 411 BRCA1 mutation carriers (170 cases and 241 controls). We estimated the odds ratios (ORs) and 95% confidence intervals (95% CIs) for breast cancer associated with the CYP1A2 genotype and a history of coffee consumption before age 35, adjusting for potential confounders. The CYP1A2 genotype did not affect breast cancer risk. Among women with at least one variant C allele (AC or CC), those who consumed coffee had a 64% reduction in breast cancer risk, compared with women who never consumed coffee (OR, 0.36; 95% CI, 0.18-0.73). A significant protective effect of coffee consumption was not observed among women with the CYP1A2 AA genotype (OR, 0.93; 95% CI, 0.49-1.77). Similar results were obtained when the analysis was restricted to caffeinated coffee. This study suggests that caffeine protects against breast cancer in women with a BRCA1 mutation and illustrates the importance of integrating individual genetic variability when assessing diet-disease associations.

AB - We have recently reported that, among BRCA1 mutation carriers, the consumption of caffeinated coffee was associated with a significant reduction in breast cancer risk. Because the metabolism of caffeine is primarily by CYP1A2, we examined whether or not the CYP1A2 genotype modifies the association between a history of coffee consumption and the risk of breast cancer. A common A to C polymorphism in the CYP1A2 gene is associated with decreased enzyme inducibility and impaired caffeine metabolism. Information regarding coffee consumption habits and the CYP1A2 genotype was available for 411 BRCA1 mutation carriers (170 cases and 241 controls). We estimated the odds ratios (ORs) and 95% confidence intervals (95% CIs) for breast cancer associated with the CYP1A2 genotype and a history of coffee consumption before age 35, adjusting for potential confounders. The CYP1A2 genotype did not affect breast cancer risk. Among women with at least one variant C allele (AC or CC), those who consumed coffee had a 64% reduction in breast cancer risk, compared with women who never consumed coffee (OR, 0.36; 95% CI, 0.18-0.73). A significant protective effect of coffee consumption was not observed among women with the CYP1A2 AA genotype (OR, 0.93; 95% CI, 0.49-1.77). Similar results were obtained when the analysis was restricted to caffeinated coffee. This study suggests that caffeine protects against breast cancer in women with a BRCA1 mutation and illustrates the importance of integrating individual genetic variability when assessing diet-disease associations.

UR - http://www.scopus.com/inward/record.url?scp=34250350720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250350720&partnerID=8YFLogxK

U2 - 10.1158/1055-9965.EPI-06-1074

DO - 10.1158/1055-9965.EPI-06-1074

M3 - Article

VL - 16

SP - 912

EP - 916

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 5

ER -