The danger zone

Systematic review of the role of HMGB1 danger signalling in traumatic brain injury

Taylor M. Parker, Austin Huy Nguyen, Joshua R. Rabang, Arun Angelo Patil, Devendra K. Agrawal

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Background: Traumatic brain injuries (TBI) are associated with complex inflammatory pathways that lead to the development of secondary injuries such as cerebral ischaemia, elevated intracranial pressure and cognitive deficits. The association between intracellular danger signalling involving nuclear chromatin-binding factor, high mobility group box-1 (HMGB1) and inflammatory pathways following TBI has not yet been fully understood. Primary objective: To comprehensively review the available literature regarding the potential diagnostic, prognostic and therapeutic use of HMGB1 in TBI. Methods: A systematic literature review of studies available in PubMed using human and animal subjects was performed. A total of eight studies were included in the results. Conclusions: A comprehensive review of these reports demonstrated that, following TBI, HMGB1 is released from damaged neurons and is elevated in patient’s serum and CSF. Furthermore, these studies showed the potential for HMGB1 to serve as a prognostic biomarker and therapeutic target in patients with TBI. Thus, HMGB1 is a prospective candidate for future studies as it shows promise in treating and/or predicting the sequelae of TBI.

Original languageEnglish (US)
Pages (from-to)2-8
Number of pages7
JournalBrain Injury
Volume31
Issue number1
DOIs
StatePublished - Jan 2 2017

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Intracranial Hypertension
Therapeutic Uses
Brain Ischemia
PubMed
Chromatin
Traumatic Brain Injury
Danger
Systematic Review
Biomarkers
Neurons
Wounds and Injuries
Serum
Pathway
Therapeutics
Diagnostics
Neuron
Animals
Literature Review

All Science Journal Classification (ASJC) codes

  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

The danger zone : Systematic review of the role of HMGB1 danger signalling in traumatic brain injury. / Parker, Taylor M.; Nguyen, Austin Huy; Rabang, Joshua R.; Patil, Arun Angelo; Agrawal, Devendra K.

In: Brain Injury, Vol. 31, No. 1, 02.01.2017, p. 2-8.

Research output: Contribution to journalReview article

Parker, Taylor M. ; Nguyen, Austin Huy ; Rabang, Joshua R. ; Patil, Arun Angelo ; Agrawal, Devendra K. / The danger zone : Systematic review of the role of HMGB1 danger signalling in traumatic brain injury. In: Brain Injury. 2017 ; Vol. 31, No. 1. pp. 2-8.
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