The dawn phenomenon, an early morning glucose rise: Implications for diabetic intraday blood glucose variation

M. I. Schmidt, A. Hadji-Georgopoulos, M. Rendell, S. Margolis, A. Kowarski

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Abstract

Eleven insulin-dependent (type I) diabetic subjects were studied during a 24-h period to assess intraday blood glucose (BG) variation and related free insulin (FI) levels. Ten patients exhibited the dawn phenomenon, a rise in early morning fasting blood glucose (123 ± 81.1 m/dl; mean ± SD). This increase was positively and significantly correlated with the morning postprandial BG peak (r=0.723; P=0.012). FI/BG ratios were highest during the night (0.717 and 0.666 at 2200 and 0400 h, respectively) and lowest during the early morning (0.294 at 0800 h) (P

Original languageEnglish
Pages (from-to)579-585
Number of pages7
JournalDiabetes Care
Volume4
Issue number6
StatePublished - 1981
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Schmidt, M. I., Hadji-Georgopoulos, A., Rendell, M., Margolis, S., & Kowarski, A. (1981). The dawn phenomenon, an early morning glucose rise: Implications for diabetic intraday blood glucose variation. Diabetes Care, 4(6), 579-585.