Abstract
To determine the role of retinal axons in the development of the corticocollicular projection in mice, the lipophilic fluorescent dye, DiI, was used to compare the development of the cortical projections in phenotypically normal (C57BL/6J) mice to that of anophthalmic 129SV/CPor(J) mice. Cortical axons in anophthalmic mice found their targets and established a laminar specificity similar to those of cortical axons in normal mice despite the absence of the retinal projection. Cortical axons in normal mice reached the superior colliculus before those in anophthalmic mice and also had a faster rate of growth within the colliculus. Unlike cortical axons in normal mice in early postnatal ages, those in anophthalmic mice formed a disperse bundle in the stratum opticum. Axons labeled by focal applications of DiI into area 17 terminated in a larger and more medial area in anophthalmic mice than in normal mice. Thus, retinal axons are not essential for cortical axons to reach the superior colliculus, but they may have a role in organizing the growth of later-arriving cortical axons. Furthermore, cortical axons can terminate in the superior colliculus with a coarse topography when retinal axons are absent, but they cannot form a topographically refined projection.
| Original language | English |
|---|---|
| Pages (from-to) | 179-192 |
| Number of pages | 14 |
| Journal | Developmental Brain Research |
| Volume | 114 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 14 1999 |
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All Science Journal Classification (ASJC) codes
- Developmental Biology
- Developmental Neuroscience
Cite this
The development of corticocollicular projections in anophthalmic mice. / Khachab, Maha Y.; Bruce, Laura.
In: Developmental Brain Research, Vol. 114, No. 2, 14.05.1999, p. 179-192.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The development of corticocollicular projections in anophthalmic mice
AU - Khachab, Maha Y.
AU - Bruce, Laura
PY - 1999/5/14
Y1 - 1999/5/14
N2 - To determine the role of retinal axons in the development of the corticocollicular projection in mice, the lipophilic fluorescent dye, DiI, was used to compare the development of the cortical projections in phenotypically normal (C57BL/6J) mice to that of anophthalmic 129SV/CPor(J) mice. Cortical axons in anophthalmic mice found their targets and established a laminar specificity similar to those of cortical axons in normal mice despite the absence of the retinal projection. Cortical axons in normal mice reached the superior colliculus before those in anophthalmic mice and also had a faster rate of growth within the colliculus. Unlike cortical axons in normal mice in early postnatal ages, those in anophthalmic mice formed a disperse bundle in the stratum opticum. Axons labeled by focal applications of DiI into area 17 terminated in a larger and more medial area in anophthalmic mice than in normal mice. Thus, retinal axons are not essential for cortical axons to reach the superior colliculus, but they may have a role in organizing the growth of later-arriving cortical axons. Furthermore, cortical axons can terminate in the superior colliculus with a coarse topography when retinal axons are absent, but they cannot form a topographically refined projection.
AB - To determine the role of retinal axons in the development of the corticocollicular projection in mice, the lipophilic fluorescent dye, DiI, was used to compare the development of the cortical projections in phenotypically normal (C57BL/6J) mice to that of anophthalmic 129SV/CPor(J) mice. Cortical axons in anophthalmic mice found their targets and established a laminar specificity similar to those of cortical axons in normal mice despite the absence of the retinal projection. Cortical axons in normal mice reached the superior colliculus before those in anophthalmic mice and also had a faster rate of growth within the colliculus. Unlike cortical axons in normal mice in early postnatal ages, those in anophthalmic mice formed a disperse bundle in the stratum opticum. Axons labeled by focal applications of DiI into area 17 terminated in a larger and more medial area in anophthalmic mice than in normal mice. Thus, retinal axons are not essential for cortical axons to reach the superior colliculus, but they may have a role in organizing the growth of later-arriving cortical axons. Furthermore, cortical axons can terminate in the superior colliculus with a coarse topography when retinal axons are absent, but they cannot form a topographically refined projection.
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U2 - 10.1016/S0165-3806(99)00020-6
DO - 10.1016/S0165-3806(99)00020-6
M3 - Article
C2 - 10320757
AN - SCOPUS:0033553363
VL - 114
SP - 179
EP - 192
JO - Developmental Brain Research
JF - Developmental Brain Research
SN - 0165-3806
IS - 2
ER -