The effect of age and menopause on bone mineral density of the proximal femur

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Although the menopause has been associated with increased bone loss at several skeletal sites, it has not previously been noted in the hip, yet estrogen therapy has been reported to reduce the incidence of hip fractures. We investigated the effect of age and menopause on bone loss in the proximal femur by measuring bone mineral density (BMD) of the femoral neck, Ward's triangle, and trochanter by dual-photon absorptiometry in 263 norman women aged 20-84. Multiple regression analysis revealed a significant decrease in BMD of the femoral neck and Ward's triangle with age in both pre- and postmenopausal women (p <0.001). In the trochanter the decrease with age was significant only in postmenopausal women (p <0.001). Further analysis revealed that BMD decreased faster at all sites in the early postmenopausal years. During the first 6 years postmenopause, the decrease in BMD of the femoral neck and trochanter was 3-10 times higher than the change in the decade prior to menopause. About 20% of the lifetime femoral neck loss and 30% of the trochanteric loss occurred in the early postmenopausal period. It is concluded that both age and menopause are major determinants of BMD in the proximal femur. These findings could explain why estrogen therapy has been reported to prevent hip fracture. The rapid early postmenopausal loss in BMD of the proximal femur demonstrates the importance of starting estrogen replacement therapy immediately after menopause for maximum effect.

Original languageEnglish
Pages (from-to)639-642
Number of pages4
JournalJournal of Bone and Mineral Research
Volume4
Issue number4
StatePublished - 1989

Fingerprint

Menopause
Bone Density
Femur
Femur Neck
Postmenopause
Hip Fractures
Estrogens
Bone and Bones
Estrogen Replacement Therapy
Photon Absorptiometry
Hip
Regression Analysis
Incidence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

The effect of age and menopause on bone mineral density of the proximal femur. / Heldund, L. R.; Gallagher, John Christopher G.

In: Journal of Bone and Mineral Research, Vol. 4, No. 4, 1989, p. 639-642.

Research output: Contribution to journalArticle

@article{d4a7ac02fb9c44f596d6a4ffee3956bb,
title = "The effect of age and menopause on bone mineral density of the proximal femur",
abstract = "Although the menopause has been associated with increased bone loss at several skeletal sites, it has not previously been noted in the hip, yet estrogen therapy has been reported to reduce the incidence of hip fractures. We investigated the effect of age and menopause on bone loss in the proximal femur by measuring bone mineral density (BMD) of the femoral neck, Ward's triangle, and trochanter by dual-photon absorptiometry in 263 norman women aged 20-84. Multiple regression analysis revealed a significant decrease in BMD of the femoral neck and Ward's triangle with age in both pre- and postmenopausal women (p <0.001). In the trochanter the decrease with age was significant only in postmenopausal women (p <0.001). Further analysis revealed that BMD decreased faster at all sites in the early postmenopausal years. During the first 6 years postmenopause, the decrease in BMD of the femoral neck and trochanter was 3-10 times higher than the change in the decade prior to menopause. About 20{\%} of the lifetime femoral neck loss and 30{\%} of the trochanteric loss occurred in the early postmenopausal period. It is concluded that both age and menopause are major determinants of BMD in the proximal femur. These findings could explain why estrogen therapy has been reported to prevent hip fracture. The rapid early postmenopausal loss in BMD of the proximal femur demonstrates the importance of starting estrogen replacement therapy immediately after menopause for maximum effect.",
author = "Heldund, {L. R.} and Gallagher, {John Christopher G.}",
year = "1989",
language = "English",
volume = "4",
pages = "639--642",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - The effect of age and menopause on bone mineral density of the proximal femur

AU - Heldund, L. R.

AU - Gallagher, John Christopher G.

PY - 1989

Y1 - 1989

N2 - Although the menopause has been associated with increased bone loss at several skeletal sites, it has not previously been noted in the hip, yet estrogen therapy has been reported to reduce the incidence of hip fractures. We investigated the effect of age and menopause on bone loss in the proximal femur by measuring bone mineral density (BMD) of the femoral neck, Ward's triangle, and trochanter by dual-photon absorptiometry in 263 norman women aged 20-84. Multiple regression analysis revealed a significant decrease in BMD of the femoral neck and Ward's triangle with age in both pre- and postmenopausal women (p <0.001). In the trochanter the decrease with age was significant only in postmenopausal women (p <0.001). Further analysis revealed that BMD decreased faster at all sites in the early postmenopausal years. During the first 6 years postmenopause, the decrease in BMD of the femoral neck and trochanter was 3-10 times higher than the change in the decade prior to menopause. About 20% of the lifetime femoral neck loss and 30% of the trochanteric loss occurred in the early postmenopausal period. It is concluded that both age and menopause are major determinants of BMD in the proximal femur. These findings could explain why estrogen therapy has been reported to prevent hip fracture. The rapid early postmenopausal loss in BMD of the proximal femur demonstrates the importance of starting estrogen replacement therapy immediately after menopause for maximum effect.

AB - Although the menopause has been associated with increased bone loss at several skeletal sites, it has not previously been noted in the hip, yet estrogen therapy has been reported to reduce the incidence of hip fractures. We investigated the effect of age and menopause on bone loss in the proximal femur by measuring bone mineral density (BMD) of the femoral neck, Ward's triangle, and trochanter by dual-photon absorptiometry in 263 norman women aged 20-84. Multiple regression analysis revealed a significant decrease in BMD of the femoral neck and Ward's triangle with age in both pre- and postmenopausal women (p <0.001). In the trochanter the decrease with age was significant only in postmenopausal women (p <0.001). Further analysis revealed that BMD decreased faster at all sites in the early postmenopausal years. During the first 6 years postmenopause, the decrease in BMD of the femoral neck and trochanter was 3-10 times higher than the change in the decade prior to menopause. About 20% of the lifetime femoral neck loss and 30% of the trochanteric loss occurred in the early postmenopausal period. It is concluded that both age and menopause are major determinants of BMD in the proximal femur. These findings could explain why estrogen therapy has been reported to prevent hip fracture. The rapid early postmenopausal loss in BMD of the proximal femur demonstrates the importance of starting estrogen replacement therapy immediately after menopause for maximum effect.

UR - http://www.scopus.com/inward/record.url?scp=0024396552&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024396552&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 639

EP - 642

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 4

ER -