The effect of age on methacholine response

Russell J. Hopp, Againdra K. Bewtra, Nicki M. Nair, Robert G. Townley

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Bronchial reactivity to inhaled methacholine exists in subjects with asthma but may occur in subjects with allergic rhinitis, chronic lung diseases, and during respiratory infections. In the absence of these factors, we found that age also has a significant effect on the methacholine response. One hundred forty-eight subjects, 5 to 76 years of age, were studied as normal control subjects in a natural history of asthma study. The methacholine response was measured by standard techniques. The analysis demonstrated that age had a significant effect on the methacholine response. In addition to known factors influencing the results of methacholine inhalation, young and older subjects may exhibit bronchial responses that may falsely suggest hyperreactive airway disease.

Original languageEnglish
Pages (from-to)609-613
Number of pages5
JournalJournal of Allergy and Clinical Immunology
Volume76
Issue number4
DOIs
StatePublished - 1985

Fingerprint

Methacholine Chloride
Asthma
Age Factors
Respiratory Tract Infections
Inhalation
Lung Diseases
Chronic Disease

All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy

Cite this

The effect of age on methacholine response. / Hopp, Russell J.; Bewtra, Againdra K.; Nair, Nicki M.; Townley, Robert G.

In: Journal of Allergy and Clinical Immunology, Vol. 76, No. 4, 1985, p. 609-613.

Research output: Contribution to journalArticle

Hopp, Russell J. ; Bewtra, Againdra K. ; Nair, Nicki M. ; Townley, Robert G. / The effect of age on methacholine response. In: Journal of Allergy and Clinical Immunology. 1985 ; Vol. 76, No. 4. pp. 609-613.
@article{9ae5e420604a45419c7521e597331aeb,
title = "The effect of age on methacholine response",
abstract = "Bronchial reactivity to inhaled methacholine exists in subjects with asthma but may occur in subjects with allergic rhinitis, chronic lung diseases, and during respiratory infections. In the absence of these factors, we found that age also has a significant effect on the methacholine response. One hundred forty-eight subjects, 5 to 76 years of age, were studied as normal control subjects in a natural history of asthma study. The methacholine response was measured by standard techniques. The analysis demonstrated that age had a significant effect on the methacholine response. In addition to known factors influencing the results of methacholine inhalation, young and older subjects may exhibit bronchial responses that may falsely suggest hyperreactive airway disease.",
author = "Hopp, {Russell J.} and Bewtra, {Againdra K.} and Nair, {Nicki M.} and Townley, {Robert G.}",
year = "1985",
doi = "10.1016/0091-6749(85)90783-3",
language = "English",
volume = "76",
pages = "609--613",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - The effect of age on methacholine response

AU - Hopp, Russell J.

AU - Bewtra, Againdra K.

AU - Nair, Nicki M.

AU - Townley, Robert G.

PY - 1985

Y1 - 1985

N2 - Bronchial reactivity to inhaled methacholine exists in subjects with asthma but may occur in subjects with allergic rhinitis, chronic lung diseases, and during respiratory infections. In the absence of these factors, we found that age also has a significant effect on the methacholine response. One hundred forty-eight subjects, 5 to 76 years of age, were studied as normal control subjects in a natural history of asthma study. The methacholine response was measured by standard techniques. The analysis demonstrated that age had a significant effect on the methacholine response. In addition to known factors influencing the results of methacholine inhalation, young and older subjects may exhibit bronchial responses that may falsely suggest hyperreactive airway disease.

AB - Bronchial reactivity to inhaled methacholine exists in subjects with asthma but may occur in subjects with allergic rhinitis, chronic lung diseases, and during respiratory infections. In the absence of these factors, we found that age also has a significant effect on the methacholine response. One hundred forty-eight subjects, 5 to 76 years of age, were studied as normal control subjects in a natural history of asthma study. The methacholine response was measured by standard techniques. The analysis demonstrated that age had a significant effect on the methacholine response. In addition to known factors influencing the results of methacholine inhalation, young and older subjects may exhibit bronchial responses that may falsely suggest hyperreactive airway disease.

UR - http://www.scopus.com/inward/record.url?scp=0021933763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021933763&partnerID=8YFLogxK

U2 - 10.1016/0091-6749(85)90783-3

DO - 10.1016/0091-6749(85)90783-3

M3 - Article

VL - 76

SP - 609

EP - 613

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 4

ER -