Abstract
The common ability of theophylline and epinephrine to protect asthmatic patients against inhalation challenge, to protect mice sensitized to histamine by beta-adrenergic blockade, to produce hyperglycemia, and to alter the levels of liver and muscle glycogen has prompted a comparison of these effects with and without the prior administration of corticosteroids. In intact CFW mice epinephrine was protective against histamine and caused hyperglycemia. However, in adrenalectomized CFW mice epinephrine was neither protective against histamine nor did it cause hyperglycemia except when cortisone was administered. Contrawise, in CF1 mice even the combination of adrenalectomy and beta-adrenergic blockade with MJ-1999 (5 mg. per kilogram) fails to produce histamine sensitivity or prevent epinephrine hyperglycemia. However, liver glycogen is depleted in both strains of mice by epinephrine. In intact CFW mice under the experimental conditions employed, aminophylline induced glycogenolysis in liver but not in muscle in the presence of beta-adrenergic blockade. In fact, muscle glycogenesis increased with increasing doses of beta-adrenergic blockade in the presence of either aminophylline or epinephrine and correlated with the degree of histamine sensitivity. If another group of identically prepared mice are pretreated with hydrocortisone, there is restoration of the glycemic abnormality, increased liver glycogen, normalization of the muscle glycogen, and protection against histamine. These findings indicate that it is the increased peripheral uptake of glucose into glycogen rather than the level of glucose in the blood that more closely parallels sensitization to histamine challenge. The effect of corticosteroids in the adrenergically beta-blocked mouse reacting by themselves or enhancing the effect of theophylline or epinephrine may be interpreted in light of their effect on cyclic AMP by sensitizing the beta receptors, that is, lowering the receptor threshold to catecholamine action. It is postulated that corticosteroids work through a similar mechanism in bronchial asthma.
| Original language | English |
|---|---|
| Pages (from-to) | 87-91 |
| Number of pages | 5 |
| Journal | Journal of Allergy |
| Volume | 45 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1970 |
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The effect of agents used in the treatment of bronchial asthma on carbohydrate metabolism and histamine sensitivity after beta-adrenergic blockade. / Townley, Robert G.; Daley, Dennis; Selenke, William.
In: Journal of Allergy, Vol. 45, No. 2, 1970, p. 87-91.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of agents used in the treatment of bronchial asthma on carbohydrate metabolism and histamine sensitivity after beta-adrenergic blockade
AU - Townley, Robert G.
AU - Daley, Dennis
AU - Selenke, William
PY - 1970
Y1 - 1970
N2 - The common ability of theophylline and epinephrine to protect asthmatic patients against inhalation challenge, to protect mice sensitized to histamine by beta-adrenergic blockade, to produce hyperglycemia, and to alter the levels of liver and muscle glycogen has prompted a comparison of these effects with and without the prior administration of corticosteroids. In intact CFW mice epinephrine was protective against histamine and caused hyperglycemia. However, in adrenalectomized CFW mice epinephrine was neither protective against histamine nor did it cause hyperglycemia except when cortisone was administered. Contrawise, in CF1 mice even the combination of adrenalectomy and beta-adrenergic blockade with MJ-1999 (5 mg. per kilogram) fails to produce histamine sensitivity or prevent epinephrine hyperglycemia. However, liver glycogen is depleted in both strains of mice by epinephrine. In intact CFW mice under the experimental conditions employed, aminophylline induced glycogenolysis in liver but not in muscle in the presence of beta-adrenergic blockade. In fact, muscle glycogenesis increased with increasing doses of beta-adrenergic blockade in the presence of either aminophylline or epinephrine and correlated with the degree of histamine sensitivity. If another group of identically prepared mice are pretreated with hydrocortisone, there is restoration of the glycemic abnormality, increased liver glycogen, normalization of the muscle glycogen, and protection against histamine. These findings indicate that it is the increased peripheral uptake of glucose into glycogen rather than the level of glucose in the blood that more closely parallels sensitization to histamine challenge. The effect of corticosteroids in the adrenergically beta-blocked mouse reacting by themselves or enhancing the effect of theophylline or epinephrine may be interpreted in light of their effect on cyclic AMP by sensitizing the beta receptors, that is, lowering the receptor threshold to catecholamine action. It is postulated that corticosteroids work through a similar mechanism in bronchial asthma.
AB - The common ability of theophylline and epinephrine to protect asthmatic patients against inhalation challenge, to protect mice sensitized to histamine by beta-adrenergic blockade, to produce hyperglycemia, and to alter the levels of liver and muscle glycogen has prompted a comparison of these effects with and without the prior administration of corticosteroids. In intact CFW mice epinephrine was protective against histamine and caused hyperglycemia. However, in adrenalectomized CFW mice epinephrine was neither protective against histamine nor did it cause hyperglycemia except when cortisone was administered. Contrawise, in CF1 mice even the combination of adrenalectomy and beta-adrenergic blockade with MJ-1999 (5 mg. per kilogram) fails to produce histamine sensitivity or prevent epinephrine hyperglycemia. However, liver glycogen is depleted in both strains of mice by epinephrine. In intact CFW mice under the experimental conditions employed, aminophylline induced glycogenolysis in liver but not in muscle in the presence of beta-adrenergic blockade. In fact, muscle glycogenesis increased with increasing doses of beta-adrenergic blockade in the presence of either aminophylline or epinephrine and correlated with the degree of histamine sensitivity. If another group of identically prepared mice are pretreated with hydrocortisone, there is restoration of the glycemic abnormality, increased liver glycogen, normalization of the muscle glycogen, and protection against histamine. These findings indicate that it is the increased peripheral uptake of glucose into glycogen rather than the level of glucose in the blood that more closely parallels sensitization to histamine challenge. The effect of corticosteroids in the adrenergically beta-blocked mouse reacting by themselves or enhancing the effect of theophylline or epinephrine may be interpreted in light of their effect on cyclic AMP by sensitizing the beta receptors, that is, lowering the receptor threshold to catecholamine action. It is postulated that corticosteroids work through a similar mechanism in bronchial asthma.
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U2 - 10.1016/0021-8707(70)90049-3
DO - 10.1016/0021-8707(70)90049-3
M3 - Article
AN - SCOPUS:49849117012
VL - 45
SP - 87
EP - 91
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 2
ER -