The effect of chronic hypertension on skin blood flow

Marc S. Rendell, Brian K. Milliken, Emily J. Banset, Mary Finnegan, Christopher Stanosheck, John V. Terando

Research output: Contribution to journalArticle

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Abstract

Objective: To determine whether the cutaneous microvasculature of the spontaneously hypertensive rat (SHR) is affected by chronic hypertension. Design: We used laser Doppler techniques to measure skin blood flow in 22 SHR and in 22 non-hypertensive Wistar-Kyoto (WKY) rats over a 1-year time span, beginning at age 3 months. Sites of measurement included the back, leg, and root of the tail, areas with a predominantly nutritive perfusion, and the plantar surface of the paw, which has a large contribution from large arterioles and venules. Flow was measured at basal skin temperature and at the maximally heat-stimulated condition of 44°C. Systolic tail arterial blood pressures were measured concurrently. Results: At baseline, systolic blood pressures were considerably higher in the SHR (190 ± 4 mmHg) than they were in the WKY rats (138 ± 2 mmHg). Skin blood flow values at the three nutritive sites were similar in the two species. However, at 44°C, flow was significantly higher at the paw in the SHR (46.8 ± 3.5 versus 34.3 ± 2.2 ml/min per 100 g). We attribute this difference to the effect of high perfusion pressure on large arterioles. During the 1-year measurement period, there was no appreciable change in blood flow in the WKY rats. In contrast, the SHR showed a steady progressive decline in skin blood flow at all sites. The largest decline was at the paw with a rate of fall of about 2.4%/month. After 1 year, there was no difference between paw blood flow in the SHR (27.5 ± 1.8 ml/min per 100 g) and in the WKY rats (27.6 ± 1.9 ml/min per 100 g). Conclusions: Skin blood flow reserve falls in response to chronic hypertension. The rate of fall is greater at sites with significant arteriovenous perfusion than at nutritive sites.

Original languageEnglish
Pages (from-to)609-614
Number of pages6
JournalJournal of Hypertension
Volume14
Issue number5
DOIs
StatePublished - 1996

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Inbred SHR Rats
Inbred WKY Rats
Hypertension
Skin
Perfusion
Arterioles
Tail
Blood Pressure
Venules
Skin Temperature
Microvessels
Leg
Arterial Pressure
Lasers
Hot Temperature
Pressure

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Internal Medicine

Cite this

Rendell, M. S., Milliken, B. K., Banset, E. J., Finnegan, M., Stanosheck, C., & Terando, J. V. (1996). The effect of chronic hypertension on skin blood flow. Journal of Hypertension, 14(5), 609-614. https://doi.org/10.1097/00004872-199605000-00010

The effect of chronic hypertension on skin blood flow. / Rendell, Marc S.; Milliken, Brian K.; Banset, Emily J.; Finnegan, Mary; Stanosheck, Christopher; Terando, John V.

In: Journal of Hypertension, Vol. 14, No. 5, 1996, p. 609-614.

Research output: Contribution to journalArticle

Rendell, MS, Milliken, BK, Banset, EJ, Finnegan, M, Stanosheck, C & Terando, JV 1996, 'The effect of chronic hypertension on skin blood flow', Journal of Hypertension, vol. 14, no. 5, pp. 609-614. https://doi.org/10.1097/00004872-199605000-00010
Rendell MS, Milliken BK, Banset EJ, Finnegan M, Stanosheck C, Terando JV. The effect of chronic hypertension on skin blood flow. Journal of Hypertension. 1996;14(5):609-614. https://doi.org/10.1097/00004872-199605000-00010
Rendell, Marc S. ; Milliken, Brian K. ; Banset, Emily J. ; Finnegan, Mary ; Stanosheck, Christopher ; Terando, John V. / The effect of chronic hypertension on skin blood flow. In: Journal of Hypertension. 1996 ; Vol. 14, No. 5. pp. 609-614.
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abstract = "Objective: To determine whether the cutaneous microvasculature of the spontaneously hypertensive rat (SHR) is affected by chronic hypertension. Design: We used laser Doppler techniques to measure skin blood flow in 22 SHR and in 22 non-hypertensive Wistar-Kyoto (WKY) rats over a 1-year time span, beginning at age 3 months. Sites of measurement included the back, leg, and root of the tail, areas with a predominantly nutritive perfusion, and the plantar surface of the paw, which has a large contribution from large arterioles and venules. Flow was measured at basal skin temperature and at the maximally heat-stimulated condition of 44°C. Systolic tail arterial blood pressures were measured concurrently. Results: At baseline, systolic blood pressures were considerably higher in the SHR (190 ± 4 mmHg) than they were in the WKY rats (138 ± 2 mmHg). Skin blood flow values at the three nutritive sites were similar in the two species. However, at 44°C, flow was significantly higher at the paw in the SHR (46.8 ± 3.5 versus 34.3 ± 2.2 ml/min per 100 g). We attribute this difference to the effect of high perfusion pressure on large arterioles. During the 1-year measurement period, there was no appreciable change in blood flow in the WKY rats. In contrast, the SHR showed a steady progressive decline in skin blood flow at all sites. The largest decline was at the paw with a rate of fall of about 2.4{\%}/month. After 1 year, there was no difference between paw blood flow in the SHR (27.5 ± 1.8 ml/min per 100 g) and in the WKY rats (27.6 ± 1.9 ml/min per 100 g). Conclusions: Skin blood flow reserve falls in response to chronic hypertension. The rate of fall is greater at sites with significant arteriovenous perfusion than at nutritive sites.",
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N2 - Objective: To determine whether the cutaneous microvasculature of the spontaneously hypertensive rat (SHR) is affected by chronic hypertension. Design: We used laser Doppler techniques to measure skin blood flow in 22 SHR and in 22 non-hypertensive Wistar-Kyoto (WKY) rats over a 1-year time span, beginning at age 3 months. Sites of measurement included the back, leg, and root of the tail, areas with a predominantly nutritive perfusion, and the plantar surface of the paw, which has a large contribution from large arterioles and venules. Flow was measured at basal skin temperature and at the maximally heat-stimulated condition of 44°C. Systolic tail arterial blood pressures were measured concurrently. Results: At baseline, systolic blood pressures were considerably higher in the SHR (190 ± 4 mmHg) than they were in the WKY rats (138 ± 2 mmHg). Skin blood flow values at the three nutritive sites were similar in the two species. However, at 44°C, flow was significantly higher at the paw in the SHR (46.8 ± 3.5 versus 34.3 ± 2.2 ml/min per 100 g). We attribute this difference to the effect of high perfusion pressure on large arterioles. During the 1-year measurement period, there was no appreciable change in blood flow in the WKY rats. In contrast, the SHR showed a steady progressive decline in skin blood flow at all sites. The largest decline was at the paw with a rate of fall of about 2.4%/month. After 1 year, there was no difference between paw blood flow in the SHR (27.5 ± 1.8 ml/min per 100 g) and in the WKY rats (27.6 ± 1.9 ml/min per 100 g). Conclusions: Skin blood flow reserve falls in response to chronic hypertension. The rate of fall is greater at sites with significant arteriovenous perfusion than at nutritive sites.

AB - Objective: To determine whether the cutaneous microvasculature of the spontaneously hypertensive rat (SHR) is affected by chronic hypertension. Design: We used laser Doppler techniques to measure skin blood flow in 22 SHR and in 22 non-hypertensive Wistar-Kyoto (WKY) rats over a 1-year time span, beginning at age 3 months. Sites of measurement included the back, leg, and root of the tail, areas with a predominantly nutritive perfusion, and the plantar surface of the paw, which has a large contribution from large arterioles and venules. Flow was measured at basal skin temperature and at the maximally heat-stimulated condition of 44°C. Systolic tail arterial blood pressures were measured concurrently. Results: At baseline, systolic blood pressures were considerably higher in the SHR (190 ± 4 mmHg) than they were in the WKY rats (138 ± 2 mmHg). Skin blood flow values at the three nutritive sites were similar in the two species. However, at 44°C, flow was significantly higher at the paw in the SHR (46.8 ± 3.5 versus 34.3 ± 2.2 ml/min per 100 g). We attribute this difference to the effect of high perfusion pressure on large arterioles. During the 1-year measurement period, there was no appreciable change in blood flow in the WKY rats. In contrast, the SHR showed a steady progressive decline in skin blood flow at all sites. The largest decline was at the paw with a rate of fall of about 2.4%/month. After 1 year, there was no difference between paw blood flow in the SHR (27.5 ± 1.8 ml/min per 100 g) and in the WKY rats (27.6 ± 1.9 ml/min per 100 g). Conclusions: Skin blood flow reserve falls in response to chronic hypertension. The rate of fall is greater at sites with significant arteriovenous perfusion than at nutritive sites.

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