The effect of phencyclidine on the turnover rate of acetylcholine in various regions of rat brain

Thomas F. Murray, D. L. Cheney

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Although the mechanism of action of phencyclidine is poorly understood, an interaction of phencyclidine with central cholinergic systems has been proposed. To test this hypothesis directly, we investigated the effects of this compound on the turnover rate of acetylcholine (TR(ACh) in various areas of the rat brain. In doses of 14.3 to 114.4 μmol/kg (i.p.), phencyclidine increased the (TR(ACh) in the frontal cortex, parietal cortex and diencephalon when rats were sacrificed 30 min after drug treatment. In contrast, these doses of phencyclidine had no effect on the (TR(ACh) in the hippocampus or striatum. The increases in cortical and diencephalic (TR(ACh) were temporally correlated with the behavioral activity elicited by phencyclidine. A 7 day chronic treatment regimen (28.6 μmol/kg/day) provided no evidence for tolerance development to the effects of phencyclidine on the (TR(ACh) in the frontal cortex or diencephalon. These results demonstrate that phencyclidine differentially affects cholinergic dynamics in various areas of the rat brain. The neurochemical profile of phencyclidine reported herein is similar to those previously described for central stimulants such as d-amphetamine, nomifensine and cocaine.

Original languageEnglish
Pages (from-to)733-737
Number of pages5
JournalJournal of Pharmacology and Experimental Therapeutics
Volume217
Issue number3
StatePublished - 1981
Externally publishedYes

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Phencyclidine
Acetylcholine
Brain
Diencephalon
Frontal Lobe
Cholinergic Agents
Nomifensine
Central Nervous System Stimulants
Dextroamphetamine
Parietal Lobe
Cocaine
Hippocampus

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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