Abstract
Although the mechanism of action of phencyclidine is poorly understood, an interaction of phencyclidine with central cholinergic systems has been proposed. To test this hypothesis directly, we investigated the effects of this compound on the turnover rate of acetylcholine (TR(ACh) in various areas of the rat brain. In doses of 14.3 to 114.4 μmol/kg (i.p.), phencyclidine increased the (TR(ACh) in the frontal cortex, parietal cortex and diencephalon when rats were sacrificed 30 min after drug treatment. In contrast, these doses of phencyclidine had no effect on the (TR(ACh) in the hippocampus or striatum. The increases in cortical and diencephalic (TR(ACh) were temporally correlated with the behavioral activity elicited by phencyclidine. A 7 day chronic treatment regimen (28.6 μmol/kg/day) provided no evidence for tolerance development to the effects of phencyclidine on the (TR(ACh) in the frontal cortex or diencephalon. These results demonstrate that phencyclidine differentially affects cholinergic dynamics in various areas of the rat brain. The neurochemical profile of phencyclidine reported herein is similar to those previously described for central stimulants such as d-amphetamine, nomifensine and cocaine.
| Original language | English |
|---|---|
| Pages (from-to) | 733-737 |
| Number of pages | 5 |
| Journal | Journal of Pharmacology and Experimental Therapeutics |
| Volume | 217 |
| Issue number | 3 |
| State | Published - 1981 |
| Externally published | Yes |
Fingerprint
All Science Journal Classification (ASJC) codes
- Pharmacology
Cite this
The effect of phencyclidine on the turnover rate of acetylcholine in various regions of rat brain. / Murray, Thomas F.; Cheney, D. L.
In: Journal of Pharmacology and Experimental Therapeutics, Vol. 217, No. 3, 1981, p. 733-737.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of phencyclidine on the turnover rate of acetylcholine in various regions of rat brain
AU - Murray, Thomas F.
AU - Cheney, D. L.
PY - 1981
Y1 - 1981
N2 - Although the mechanism of action of phencyclidine is poorly understood, an interaction of phencyclidine with central cholinergic systems has been proposed. To test this hypothesis directly, we investigated the effects of this compound on the turnover rate of acetylcholine (TR(ACh) in various areas of the rat brain. In doses of 14.3 to 114.4 μmol/kg (i.p.), phencyclidine increased the (TR(ACh) in the frontal cortex, parietal cortex and diencephalon when rats were sacrificed 30 min after drug treatment. In contrast, these doses of phencyclidine had no effect on the (TR(ACh) in the hippocampus or striatum. The increases in cortical and diencephalic (TR(ACh) were temporally correlated with the behavioral activity elicited by phencyclidine. A 7 day chronic treatment regimen (28.6 μmol/kg/day) provided no evidence for tolerance development to the effects of phencyclidine on the (TR(ACh) in the frontal cortex or diencephalon. These results demonstrate that phencyclidine differentially affects cholinergic dynamics in various areas of the rat brain. The neurochemical profile of phencyclidine reported herein is similar to those previously described for central stimulants such as d-amphetamine, nomifensine and cocaine.
AB - Although the mechanism of action of phencyclidine is poorly understood, an interaction of phencyclidine with central cholinergic systems has been proposed. To test this hypothesis directly, we investigated the effects of this compound on the turnover rate of acetylcholine (TR(ACh) in various areas of the rat brain. In doses of 14.3 to 114.4 μmol/kg (i.p.), phencyclidine increased the (TR(ACh) in the frontal cortex, parietal cortex and diencephalon when rats were sacrificed 30 min after drug treatment. In contrast, these doses of phencyclidine had no effect on the (TR(ACh) in the hippocampus or striatum. The increases in cortical and diencephalic (TR(ACh) were temporally correlated with the behavioral activity elicited by phencyclidine. A 7 day chronic treatment regimen (28.6 μmol/kg/day) provided no evidence for tolerance development to the effects of phencyclidine on the (TR(ACh) in the frontal cortex or diencephalon. These results demonstrate that phencyclidine differentially affects cholinergic dynamics in various areas of the rat brain. The neurochemical profile of phencyclidine reported herein is similar to those previously described for central stimulants such as d-amphetamine, nomifensine and cocaine.
UR - http://www.scopus.com/inward/record.url?scp=0019442435&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019442435&partnerID=8YFLogxK
M3 - Article
C2 - 7230002
AN - SCOPUS:0019442435
VL - 217
SP - 733
EP - 737
JO - Journal of Pharmacology and Experimental Therapeutics
JF - Journal of Pharmacology and Experimental Therapeutics
SN - 0022-3565
IS - 3
ER -