The effect of postnatal age on gentamicin pharmacokinetics in neonates

Jennifer A. Knight, Estella M. Davis, Konstantine Manouilov, Eric B. Hoie

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Study Objective. To determine if gentamicin serum concentrations obtained from newborns on day 2 of life versus days 3-4 yield significantly different pharmacokinetic parameter values. Design. Retrospective chart review. Setting. Neonatal intensive care unit. Patients. Two hundred and sixty-seven infants who had peak and trough gentamicin serum concentrations determined on days 2, 3, or 4 of life. Intervention. Determination of peak and trough serum gentamicin concentrations on days 2, 3, or 4 of life. Measurements and Main Results. The elimination rate constant, serum half-life, volume of distribution, and clearance of gentamicin were calculated using a one-compartment pharmacokinetic model. Gestational age, birthweight, gentamicin dosage, peak and trough gentamicin concentrations, and hours after birth at which serum concentrations were drawn were recorded for all infants. Infants were stratified into three groups based on gestational age: 28 weeks or younger, older than 28 weeks but younger than 37 weeks, and 37 weeks or older. Birthweight and calculated pharmacokinetic parameters were compared by 2-tailed Student t test to determine if significant differences existed between pharmacokinetics parameters determined on day 2 of life versus days 3 or 4 within each of the gestational age groups. These analyses revealed only one significant difference between parameters assessed on day 2 versus days 3 or 4: at day 2, the mean trough concentration of gentamicin in infants of gestational age between 28 and 37 weeks was 1.63 ± 0.44 mg/L, whereas at days 3 or 4, the same parameter for patients of the same gestational age was 1.4 ± 0.48 mg/L (p=0.005). Conclusions. With one exception - elevated trough concentrations in infants in the gestational age group between 28 and 37 weeks - pharmacokinetic parameters calculated using gentamicin serum concentrations determined on day 2 of life are not significantly different from those derived from gentamicin serum concentrations determined on days 3 or 4. This suggests that gentamicin serum concentrations and subsequent dosage adjustments can be determined on day 2 of life.

Original languageEnglish
Pages (from-to)992-996
Number of pages5
JournalPharmacotherapy
Volume23
Issue number8
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

Fingerprint

Gentamicins
Pharmacokinetics
Newborn Infant
Gestational Age
Serum
Age Groups
Neonatal Intensive Care Units
Half-Life
Parturition
Students

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

The effect of postnatal age on gentamicin pharmacokinetics in neonates. / Knight, Jennifer A.; Davis, Estella M.; Manouilov, Konstantine; Hoie, Eric B.

In: Pharmacotherapy, Vol. 23, No. 8, 01.08.2003, p. 992-996.

Research output: Contribution to journalArticle

Knight, Jennifer A. ; Davis, Estella M. ; Manouilov, Konstantine ; Hoie, Eric B. / The effect of postnatal age on gentamicin pharmacokinetics in neonates. In: Pharmacotherapy. 2003 ; Vol. 23, No. 8. pp. 992-996.
@article{1de292b8027e4ec8ba44cc4d50058d0c,
title = "The effect of postnatal age on gentamicin pharmacokinetics in neonates",
abstract = "Study Objective. To determine if gentamicin serum concentrations obtained from newborns on day 2 of life versus days 3-4 yield significantly different pharmacokinetic parameter values. Design. Retrospective chart review. Setting. Neonatal intensive care unit. Patients. Two hundred and sixty-seven infants who had peak and trough gentamicin serum concentrations determined on days 2, 3, or 4 of life. Intervention. Determination of peak and trough serum gentamicin concentrations on days 2, 3, or 4 of life. Measurements and Main Results. The elimination rate constant, serum half-life, volume of distribution, and clearance of gentamicin were calculated using a one-compartment pharmacokinetic model. Gestational age, birthweight, gentamicin dosage, peak and trough gentamicin concentrations, and hours after birth at which serum concentrations were drawn were recorded for all infants. Infants were stratified into three groups based on gestational age: 28 weeks or younger, older than 28 weeks but younger than 37 weeks, and 37 weeks or older. Birthweight and calculated pharmacokinetic parameters were compared by 2-tailed Student t test to determine if significant differences existed between pharmacokinetics parameters determined on day 2 of life versus days 3 or 4 within each of the gestational age groups. These analyses revealed only one significant difference between parameters assessed on day 2 versus days 3 or 4: at day 2, the mean trough concentration of gentamicin in infants of gestational age between 28 and 37 weeks was 1.63 ± 0.44 mg/L, whereas at days 3 or 4, the same parameter for patients of the same gestational age was 1.4 ± 0.48 mg/L (p=0.005). Conclusions. With one exception - elevated trough concentrations in infants in the gestational age group between 28 and 37 weeks - pharmacokinetic parameters calculated using gentamicin serum concentrations determined on day 2 of life are not significantly different from those derived from gentamicin serum concentrations determined on days 3 or 4. This suggests that gentamicin serum concentrations and subsequent dosage adjustments can be determined on day 2 of life.",
author = "Knight, {Jennifer A.} and Davis, {Estella M.} and Konstantine Manouilov and Hoie, {Eric B.}",
year = "2003",
month = "8",
day = "1",
doi = "10.1592/phco.23.8.992.32877",
language = "English",
volume = "23",
pages = "992--996",
journal = "Pharmacotherapy",
issn = "0277-0008",
publisher = "Pharmacotherapy Publications Inc.",
number = "8",

}

TY - JOUR

T1 - The effect of postnatal age on gentamicin pharmacokinetics in neonates

AU - Knight, Jennifer A.

AU - Davis, Estella M.

AU - Manouilov, Konstantine

AU - Hoie, Eric B.

PY - 2003/8/1

Y1 - 2003/8/1

N2 - Study Objective. To determine if gentamicin serum concentrations obtained from newborns on day 2 of life versus days 3-4 yield significantly different pharmacokinetic parameter values. Design. Retrospective chart review. Setting. Neonatal intensive care unit. Patients. Two hundred and sixty-seven infants who had peak and trough gentamicin serum concentrations determined on days 2, 3, or 4 of life. Intervention. Determination of peak and trough serum gentamicin concentrations on days 2, 3, or 4 of life. Measurements and Main Results. The elimination rate constant, serum half-life, volume of distribution, and clearance of gentamicin were calculated using a one-compartment pharmacokinetic model. Gestational age, birthweight, gentamicin dosage, peak and trough gentamicin concentrations, and hours after birth at which serum concentrations were drawn were recorded for all infants. Infants were stratified into three groups based on gestational age: 28 weeks or younger, older than 28 weeks but younger than 37 weeks, and 37 weeks or older. Birthweight and calculated pharmacokinetic parameters were compared by 2-tailed Student t test to determine if significant differences existed between pharmacokinetics parameters determined on day 2 of life versus days 3 or 4 within each of the gestational age groups. These analyses revealed only one significant difference between parameters assessed on day 2 versus days 3 or 4: at day 2, the mean trough concentration of gentamicin in infants of gestational age between 28 and 37 weeks was 1.63 ± 0.44 mg/L, whereas at days 3 or 4, the same parameter for patients of the same gestational age was 1.4 ± 0.48 mg/L (p=0.005). Conclusions. With one exception - elevated trough concentrations in infants in the gestational age group between 28 and 37 weeks - pharmacokinetic parameters calculated using gentamicin serum concentrations determined on day 2 of life are not significantly different from those derived from gentamicin serum concentrations determined on days 3 or 4. This suggests that gentamicin serum concentrations and subsequent dosage adjustments can be determined on day 2 of life.

AB - Study Objective. To determine if gentamicin serum concentrations obtained from newborns on day 2 of life versus days 3-4 yield significantly different pharmacokinetic parameter values. Design. Retrospective chart review. Setting. Neonatal intensive care unit. Patients. Two hundred and sixty-seven infants who had peak and trough gentamicin serum concentrations determined on days 2, 3, or 4 of life. Intervention. Determination of peak and trough serum gentamicin concentrations on days 2, 3, or 4 of life. Measurements and Main Results. The elimination rate constant, serum half-life, volume of distribution, and clearance of gentamicin were calculated using a one-compartment pharmacokinetic model. Gestational age, birthweight, gentamicin dosage, peak and trough gentamicin concentrations, and hours after birth at which serum concentrations were drawn were recorded for all infants. Infants were stratified into three groups based on gestational age: 28 weeks or younger, older than 28 weeks but younger than 37 weeks, and 37 weeks or older. Birthweight and calculated pharmacokinetic parameters were compared by 2-tailed Student t test to determine if significant differences existed between pharmacokinetics parameters determined on day 2 of life versus days 3 or 4 within each of the gestational age groups. These analyses revealed only one significant difference between parameters assessed on day 2 versus days 3 or 4: at day 2, the mean trough concentration of gentamicin in infants of gestational age between 28 and 37 weeks was 1.63 ± 0.44 mg/L, whereas at days 3 or 4, the same parameter for patients of the same gestational age was 1.4 ± 0.48 mg/L (p=0.005). Conclusions. With one exception - elevated trough concentrations in infants in the gestational age group between 28 and 37 weeks - pharmacokinetic parameters calculated using gentamicin serum concentrations determined on day 2 of life are not significantly different from those derived from gentamicin serum concentrations determined on days 3 or 4. This suggests that gentamicin serum concentrations and subsequent dosage adjustments can be determined on day 2 of life.

UR - http://www.scopus.com/inward/record.url?scp=0041348024&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041348024&partnerID=8YFLogxK

U2 - 10.1592/phco.23.8.992.32877

DO - 10.1592/phco.23.8.992.32877

M3 - Article

C2 - 12921246

AN - SCOPUS:0041348024

VL - 23

SP - 992

EP - 996

JO - Pharmacotherapy

JF - Pharmacotherapy

SN - 0277-0008

IS - 8

ER -