The effect of quinine on outer hair cell shape, compliance and force

John K. Jarboe, Richard J. Hallworth

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Quinine intoxication causes a well-described syndrome that includes tinnitus, sensorineural hearing loss and vertigo. The pathophysiology of quinine's effects on hearing is unknown, but may include a peripheral component. The cochlear outer hair cell is known to be motile and to contribute force to amplify the vibration pattern of the organ of Corti. The outer hair cell is also a target of diseases involving tinnitus and sensorineural hearing loss, including salicylate intoxication. These effects may be mediated through changes either in motile force or in mechanical properties. Quinine's effects on outer hair cell motility and mechanical properties have therefore been examined in vitro. Quinine at 5.0 mM substantially decreased active force generation in isolated guinea pig cochlear outer hair cells. Isolated cells also elongated and dilated in diameter when exposed to 5.0 mM quinine. No consistent changes in mechanical properties were observed. 1.0 mm quinine was ineffective in either force reduction or elongation. Trifluoperazine, a calmodulin inhibitor, and ML-9, a blocker of myosin light chain kinases, were ineffective in blocking quinine- induced force reduction or elongation. Deferoxamine, a hydroxyl free radical scavenger, also failed to block either the force decrease or the elongation.

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalHearing Research
Volume132
Issue number1-2
DOIs
StatePublished - Jun 1999
Externally publishedYes

Fingerprint

Outer Auditory Hair Cells
Quinine
Cell Shape
Compliance
Tinnitus
Sensorineural Hearing Loss
Myosin-Light-Chain Kinase
Organ of Corti
Trifluoperazine
Free Radical Scavengers
Deferoxamine
Salicylates
Vertigo
Calmodulin
Vibration
Hydroxyl Radical
Hearing
Cell Movement
Guinea Pigs

All Science Journal Classification (ASJC) codes

  • Sensory Systems

Cite this

The effect of quinine on outer hair cell shape, compliance and force. / Jarboe, John K.; Hallworth, Richard J.

In: Hearing Research, Vol. 132, No. 1-2, 06.1999, p. 43-50.

Research output: Contribution to journalArticle

Jarboe, John K. ; Hallworth, Richard J. / The effect of quinine on outer hair cell shape, compliance and force. In: Hearing Research. 1999 ; Vol. 132, No. 1-2. pp. 43-50.
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