The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils

H. Miyagawa, M. Nabe, R. J. Hopp, C. Okada, Againdra K. Bewtra, G. Townley

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

We investigated the effect of WEB 2086, a selective platelet-activating factor (PAF) receptor antagonist, on PAF-induced eosinophil chemotaxis and LTC4 production. WEB 2086 inhibited PAF-induced eosinophil chemotaxis in normals and asthmatics. To further determine if WEB 2086 is a selective PAF receptor antagonist, we examined the effect of WEB 2086 against formyl-methionyl-leucyl-phenylalanine (fMLP)-induced or eosinophil chemotactic factor of anaphylaxis (ECF-A)-induced eosinophil chemotaxis. WEB 2086 did not have a significant inhibition against fMLP or ECF-A-induced eosinophil chemotaxis. These results suggest that WEB 2086 is a selective and potent inhibitor of PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils, due to its antagonism of PAF-receptors.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalAgents and Actions
Volume37
Issue number1-2
DOIs
StatePublished - Sep 1992

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology (medical)

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