Abstract
Rats were trained to respond on a variable interval 60 sec (VI-60) schedule of water reinforcement. Phencyclidine (PCD) in doses of 0.25, 0.5, and 1.0 mg/kg i.p. increased response rates, respectively, to 118%, 140%, and 143% of the control rates. In contrast, doses of 2.0 and 4.0 mg/kg decreased response rates to 73% and 6% of the control rates. In the tolerance study, one group of rats received daily treatments of 4.0 mg/kg PCD immediately prior to the operant session, while a second group received the same daily dose of PCD after the operant session. When both groups of animals were treated prior to the operant session on a test day, they both displayed complete tolerance to the rate depressant effect of PCD. These results indicate that the observed tolerance to PCD was not dependent on behavioral compensatory mechanisms.
| Original language | English |
|---|---|
| Pages (from-to) | 195-201 |
| Number of pages | 7 |
| Journal | Life Sciences |
| Volume | 22 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1978 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pharmacology
Cite this
The effects of phencyclidine on operant behavior in the rat : Biphasic effect and tolerance development. / Murray, Thomas F.
In: Life Sciences, Vol. 22, No. 2, 1978, p. 195-201.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effects of phencyclidine on operant behavior in the rat
T2 - Biphasic effect and tolerance development
AU - Murray, Thomas F.
PY - 1978
Y1 - 1978
N2 - Rats were trained to respond on a variable interval 60 sec (VI-60) schedule of water reinforcement. Phencyclidine (PCD) in doses of 0.25, 0.5, and 1.0 mg/kg i.p. increased response rates, respectively, to 118%, 140%, and 143% of the control rates. In contrast, doses of 2.0 and 4.0 mg/kg decreased response rates to 73% and 6% of the control rates. In the tolerance study, one group of rats received daily treatments of 4.0 mg/kg PCD immediately prior to the operant session, while a second group received the same daily dose of PCD after the operant session. When both groups of animals were treated prior to the operant session on a test day, they both displayed complete tolerance to the rate depressant effect of PCD. These results indicate that the observed tolerance to PCD was not dependent on behavioral compensatory mechanisms.
AB - Rats were trained to respond on a variable interval 60 sec (VI-60) schedule of water reinforcement. Phencyclidine (PCD) in doses of 0.25, 0.5, and 1.0 mg/kg i.p. increased response rates, respectively, to 118%, 140%, and 143% of the control rates. In contrast, doses of 2.0 and 4.0 mg/kg decreased response rates to 73% and 6% of the control rates. In the tolerance study, one group of rats received daily treatments of 4.0 mg/kg PCD immediately prior to the operant session, while a second group received the same daily dose of PCD after the operant session. When both groups of animals were treated prior to the operant session on a test day, they both displayed complete tolerance to the rate depressant effect of PCD. These results indicate that the observed tolerance to PCD was not dependent on behavioral compensatory mechanisms.
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U2 - 10.1016/0024-3205(78)90537-4
DO - 10.1016/0024-3205(78)90537-4
M3 - Article
VL - 22
SP - 195
EP - 201
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 2
ER -