The epidermal growth factor receptor in normal and neoplastic epithelia

Susan K. Repertinger, Justin G. Madson, Kyle J. Bichsel, Laura A. Hansen

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The epidermal growth factor receptor (EGFR) regulates a plethora of cellular and tissue functions in epithelia including cell division, survival, differentiation, and migration. EGFR signaling is up-regulated in pathologies involving aberrant growth like squamous cancer, and facilitates neoplastic progression. Many mechanisms through which the effects of EGFR are modulated in normal and pathological processes have been identified. In particular, recent research has yielded important and surprising insights into the effects of EGFR-dependent signaling on cutaneous biology and carcinogenesis. This review focuses on EGFR signaling in normal biology and squamous cancer, with emphasis on the skin as a model organ to illustrate the biological significance of EGFR signaling.

Original languageEnglish
Title of host publicationSignaling Pathways in Squamous Cancer
PublisherSpringer New York
Pages113-129
Number of pages17
ISBN (Print)9781441972026
DOIs
StatePublished - 2011

Fingerprint

Epidermal Growth Factor Receptor
Epithelium
Skin
Pathology
Pathologic Processes
Cell Division
Neoplasms
Cell Survival
Carcinogenesis
Cells
Tissue
Growth
Research

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Repertinger, S. K., Madson, J. G., Bichsel, K. J., & Hansen, L. A. (2011). The epidermal growth factor receptor in normal and neoplastic epithelia. In Signaling Pathways in Squamous Cancer (pp. 113-129). Springer New York. https://doi.org/10.1007/978-1-4419-7203-3_5

The epidermal growth factor receptor in normal and neoplastic epithelia. / Repertinger, Susan K.; Madson, Justin G.; Bichsel, Kyle J.; Hansen, Laura A.

Signaling Pathways in Squamous Cancer. Springer New York, 2011. p. 113-129.

Research output: Chapter in Book/Report/Conference proceedingChapter

Repertinger, SK, Madson, JG, Bichsel, KJ & Hansen, LA 2011, The epidermal growth factor receptor in normal and neoplastic epithelia. in Signaling Pathways in Squamous Cancer. Springer New York, pp. 113-129. https://doi.org/10.1007/978-1-4419-7203-3_5
Repertinger SK, Madson JG, Bichsel KJ, Hansen LA. The epidermal growth factor receptor in normal and neoplastic epithelia. In Signaling Pathways in Squamous Cancer. Springer New York. 2011. p. 113-129 https://doi.org/10.1007/978-1-4419-7203-3_5
Repertinger, Susan K. ; Madson, Justin G. ; Bichsel, Kyle J. ; Hansen, Laura A. / The epidermal growth factor receptor in normal and neoplastic epithelia. Signaling Pathways in Squamous Cancer. Springer New York, 2011. pp. 113-129
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