Abstract
The epidermal growth factor receptor (EGFR) regulates a plethora of cellular and tissue functions in epithelia including cell division, survival, differentiation, and migration. EGFR signaling is up-regulated in pathologies involving aberrant growth like squamous cancer, and facilitates neoplastic progression. Many mechanisms through which the effects of EGFR are modulated in normal and pathological processes have been identified. In particular, recent research has yielded important and surprising insights into the effects of EGFR-dependent signaling on cutaneous biology and carcinogenesis. This review focuses on EGFR signaling in normal biology and squamous cancer, with emphasis on the skin as a model organ to illustrate the biological significance of EGFR signaling.
| Original language | English |
|---|---|
| Title of host publication | Signaling Pathways in Squamous Cancer |
| Publisher | Springer New York |
| Pages | 113-129 |
| Number of pages | 17 |
| ISBN (Print) | 9781441972026 |
| DOIs | |
| State | Published - 2011 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
The epidermal growth factor receptor in normal and neoplastic epithelia. / Repertinger, Susan K.; Madson, Justin G.; Bichsel, Kyle J.; Hansen, Laura A.
Signaling Pathways in Squamous Cancer. Springer New York, 2011. p. 113-129.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - The epidermal growth factor receptor in normal and neoplastic epithelia
AU - Repertinger, Susan K.
AU - Madson, Justin G.
AU - Bichsel, Kyle J.
AU - Hansen, Laura A.
PY - 2011
Y1 - 2011
N2 - The epidermal growth factor receptor (EGFR) regulates a plethora of cellular and tissue functions in epithelia including cell division, survival, differentiation, and migration. EGFR signaling is up-regulated in pathologies involving aberrant growth like squamous cancer, and facilitates neoplastic progression. Many mechanisms through which the effects of EGFR are modulated in normal and pathological processes have been identified. In particular, recent research has yielded important and surprising insights into the effects of EGFR-dependent signaling on cutaneous biology and carcinogenesis. This review focuses on EGFR signaling in normal biology and squamous cancer, with emphasis on the skin as a model organ to illustrate the biological significance of EGFR signaling.
AB - The epidermal growth factor receptor (EGFR) regulates a plethora of cellular and tissue functions in epithelia including cell division, survival, differentiation, and migration. EGFR signaling is up-regulated in pathologies involving aberrant growth like squamous cancer, and facilitates neoplastic progression. Many mechanisms through which the effects of EGFR are modulated in normal and pathological processes have been identified. In particular, recent research has yielded important and surprising insights into the effects of EGFR-dependent signaling on cutaneous biology and carcinogenesis. This review focuses on EGFR signaling in normal biology and squamous cancer, with emphasis on the skin as a model organ to illustrate the biological significance of EGFR signaling.
UR - http://www.scopus.com/inward/record.url?scp=84865192441&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865192441&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-7203-3_5
DO - 10.1007/978-1-4419-7203-3_5
M3 - Chapter
AN - SCOPUS:84865192441
SN - 9781441972026
SP - 113
EP - 129
BT - Signaling Pathways in Squamous Cancer
PB - Springer New York
ER -