The epidermal growth factor receptor in normal and neoplastic epithelia

Susan K. Repertinger; Justin G. Madson; Kyle J. Bichsel; Laura A. Hansen

doi:10.1007/978-1-4419-7203-3_5

The epidermal growth factor receptor in normal and neoplastic epithelia

Susan K. Repertinger, Justin G. Madson, Kyle J. Bichsel, Laura A. Hansen

Department of Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

The epidermal growth factor receptor (EGFR) regulates a plethora of cellular and tissue functions in epithelia including cell division, survival, differentiation, and migration. EGFR signaling is up-regulated in pathologies involving aberrant growth like squamous cancer, and facilitates neoplastic progression. Many mechanisms through which the effects of EGFR are modulated in normal and pathological processes have been identified. In particular, recent research has yielded important and surprising insights into the effects of EGFR-dependent signaling on cutaneous biology and carcinogenesis. This review focuses on EGFR signaling in normal biology and squamous cancer, with emphasis on the skin as a model organ to illustrate the biological significance of EGFR signaling.

Original language	English (US)
Title of host publication	Signaling Pathways in Squamous Cancer
Publisher	Springer New York
Pages	113-129
Number of pages	17
ISBN (Print)	9781441972026
DOIs	https://doi.org/10.1007/978-1-4419-7203-3_5
State	Published - Dec 1 2011

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-1-4419-7203-3_5

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abstract = "The epidermal growth factor receptor (EGFR) regulates a plethora of cellular and tissue functions in epithelia including cell division, survival, differentiation, and migration. EGFR signaling is up-regulated in pathologies involving aberrant growth like squamous cancer, and facilitates neoplastic progression. Many mechanisms through which the effects of EGFR are modulated in normal and pathological processes have been identified. In particular, recent research has yielded important and surprising insights into the effects of EGFR-dependent signaling on cutaneous biology and carcinogenesis. This review focuses on EGFR signaling in normal biology and squamous cancer, with emphasis on the skin as a model organ to illustrate the biological significance of EGFR signaling.",

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AB - The epidermal growth factor receptor (EGFR) regulates a plethora of cellular and tissue functions in epithelia including cell division, survival, differentiation, and migration. EGFR signaling is up-regulated in pathologies involving aberrant growth like squamous cancer, and facilitates neoplastic progression. Many mechanisms through which the effects of EGFR are modulated in normal and pathological processes have been identified. In particular, recent research has yielded important and surprising insights into the effects of EGFR-dependent signaling on cutaneous biology and carcinogenesis. This review focuses on EGFR signaling in normal biology and squamous cancer, with emphasis on the skin as a model organ to illustrate the biological significance of EGFR signaling.

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The epidermal growth factor receptor in normal and neoplastic epithelia

Abstract

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