The expression patterns of c-kit and Sl in the chicken embryos suggest unexpected roles for these genes in somite and limb development

Mark V. Reedy; Randy L. Johnson; Carol A. Erickson

doi:10.1016/S1567-133X(02)00072-8

The expression patterns of c-kit and Sl in the chicken embryos suggest unexpected roles for these genes in somite and limb development

Mark V. Reedy, Randy L. Johnson, Carol A. Erickson

Department of Biology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We have used whole-mount in situ hybridization to investigate the patterns of c-kit and Sl expression in stage 11-22 chicken embryos. Our analysis shows that c-kit and Sl are expressed quite differently in chicken embryos compared to the reported expression patterns of these genes in embryos of other taxa. Most notably, chicken c-kit is expressed in primordial germ cells as well as in the developing somite, the apical ectodermal ridge, and in the early foregut endoderm. Sl is expressed in the lateral and intermediate mesoderm and in extraembryonic membranes. These data suggest that chicken c-kit and Sl may play novel and unexpected roles in somitogenesis, limb development, and foregut development in avian embryos.

Original language	English (US)
Pages (from-to)	53-58
Number of pages	6
Journal	Gene Expression Patterns
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/S1567-133X(02)00072-8
State	Published - Mar 2003

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics
Developmental Biology

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@article{feeb9270ce984aeea606a656865e309d,

title = "The expression patterns of c-kit and Sl in the chicken embryos suggest unexpected roles for these genes in somite and limb development",

abstract = "We have used whole-mount in situ hybridization to investigate the patterns of c-kit and Sl expression in stage 11-22 chicken embryos. Our analysis shows that c-kit and Sl are expressed quite differently in chicken embryos compared to the reported expression patterns of these genes in embryos of other taxa. Most notably, chicken c-kit is expressed in primordial germ cells as well as in the developing somite, the apical ectodermal ridge, and in the early foregut endoderm. Sl is expressed in the lateral and intermediate mesoderm and in extraembryonic membranes. These data suggest that chicken c-kit and Sl may play novel and unexpected roles in somitogenesis, limb development, and foregut development in avian embryos.",

author = "Reedy, {Mark V.} and Johnson, {Randy L.} and Erickson, {Carol A.}",

note = "Funding Information: We are grateful to Dr. M. Sakurai for providing full-length chicken c-kit and Sl cDNAs, to Drs. B. Wehrle-Haller and Y. Wakamatsu for suggestions about the in situ hybridization protocol, and to Drs. C. Ordahl, G. Hansen, and P. Brauer for comments on this manuscript. This work was supported by NIH grant GM53258 to C.A.E. and by NIH predoctoral and post-doctoral fellowships to M.V.R.",

year = "2003",

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doi = "10.1016/S1567-133X(02)00072-8",

language = "English (US)",

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journal = "Gene Expression Patterns",

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T1 - The expression patterns of c-kit and Sl in the chicken embryos suggest unexpected roles for these genes in somite and limb development

AU - Reedy, Mark V.

AU - Johnson, Randy L.

AU - Erickson, Carol A.

N1 - Funding Information: We are grateful to Dr. M. Sakurai for providing full-length chicken c-kit and Sl cDNAs, to Drs. B. Wehrle-Haller and Y. Wakamatsu for suggestions about the in situ hybridization protocol, and to Drs. C. Ordahl, G. Hansen, and P. Brauer for comments on this manuscript. This work was supported by NIH grant GM53258 to C.A.E. and by NIH predoctoral and post-doctoral fellowships to M.V.R.

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N2 - We have used whole-mount in situ hybridization to investigate the patterns of c-kit and Sl expression in stage 11-22 chicken embryos. Our analysis shows that c-kit and Sl are expressed quite differently in chicken embryos compared to the reported expression patterns of these genes in embryos of other taxa. Most notably, chicken c-kit is expressed in primordial germ cells as well as in the developing somite, the apical ectodermal ridge, and in the early foregut endoderm. Sl is expressed in the lateral and intermediate mesoderm and in extraembryonic membranes. These data suggest that chicken c-kit and Sl may play novel and unexpected roles in somitogenesis, limb development, and foregut development in avian embryos.

AB - We have used whole-mount in situ hybridization to investigate the patterns of c-kit and Sl expression in stage 11-22 chicken embryos. Our analysis shows that c-kit and Sl are expressed quite differently in chicken embryos compared to the reported expression patterns of these genes in embryos of other taxa. Most notably, chicken c-kit is expressed in primordial germ cells as well as in the developing somite, the apical ectodermal ridge, and in the early foregut endoderm. Sl is expressed in the lateral and intermediate mesoderm and in extraembryonic membranes. These data suggest that chicken c-kit and Sl may play novel and unexpected roles in somitogenesis, limb development, and foregut development in avian embryos.

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