The FAMMM syndrome

Epidemiology and surveillance strategies

Ramon M. Fusaro, Henry T. Lynch

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Research into the epidemiology of the melanoma-prone FAMMM syndrome, molecular genetics of the occurrences of melanoma, the photobiology of DNA damage/repair, diagnostic epiluminescence, microscopic/imaging techniques, and a new concept of photoprotection have altered melanoma strategies in surveillance and prevention. Molecular genetic research has implicated the importance of hereditary aspects of melanoma and associated malignancies. High-risk pedigrees can be identified through an informatic analysis of the occurrence patterns of melanoma and systemic cancers in kindreds. All ultraviolet radiation results in cutaneous DNA damage and in high-risk individuals may cause melanoma. We may reverse the epidemic trend in melanoma occurrences in these high-risk pedigrees if we are willing to change our cultural approach to sunlight exposure with restrictive sunlight behavior, wearing of ultraviolet protective clothes, the use of broad-spectrum ultraviolet protection from nightly topical dihydroxyacetone coupled with daytime UVB sunscreens, and periodic surveillance.

Original languageEnglish
Pages (from-to)670-680
Number of pages11
JournalCancer Investigation
Volume18
Issue number7
StatePublished - 2000

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Melanoma
Epidemiology
Sunlight
Pedigree
DNA Damage
Molecular Biology
Photobiology
Dihydroxyacetone
Sunscreening Agents
Genetic Research
Informatics
Clothing
DNA Repair
Neoplasms
Radiation
Skin
Research

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

The FAMMM syndrome : Epidemiology and surveillance strategies. / Fusaro, Ramon M.; Lynch, Henry T.

In: Cancer Investigation, Vol. 18, No. 7, 2000, p. 670-680.

Research output: Contribution to journalArticle

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