The Fat-Dachsous signaling pathway regulates growth of horns in Trypoxylus dichotomus, but does not affect horn allometry

James Hust, Mark D. Lavine, Amy Worthington, Robert Zinna, Hiroki Gotoh, T. Niimi, Laura Lavine

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Males of the Asian rhinoceros beetle, Trypoxylus dichotomus, possess exaggerated head and thoracic horns that scale dramatically out of proportion to body size. While studies of insulin signaling suggest that this pathway regulates nutrition-dependent growth including exaggerated horns, what regulates disproportionate growth has yet to be identified. The Fat signaling pathway is a potential candidate for regulating disproportionate growth of sexually-selected traits, a hypothesis we advanced in a previous paper (Gotoh et al., 2015). To investigate the role of Fat signaling in the growth and scaling of the sexually dimorphic, condition-dependent traits of the in the Asian rhinoceros beetle T. dichotomus, we used RNA interference to knock down expression of fat and its co-receptor dachsous. Knockdown of fat, and to a lesser degree dachsous, caused shortening and widening of appendages, including the head and thoracic horns. However, scaling of horns to body size was not affected. Our results show that Fat signaling regulates horn growth in T. dichotomus as it does in appendage growth in other insects. However, we provide evidence that Fat signaling does not mediate the disproportionate, positive allometric growth of horns in T. dichotomus.

Original languageEnglish (US)
Pages (from-to)85-94
Number of pages10
JournalJournal of Insect Physiology
Volume105
DOIs
StatePublished - Feb 1 2018

Fingerprint

Trypoxylus dichotomus
allometry
Horns
Fats
lipids
Growth
Rhinoceros
chest
appendages
Beetles
Body Size
body size
Coleoptera
Thorax
insect growth
Head
RNA interference
shortenings
RNA Interference
insulin

All Science Journal Classification (ASJC) codes

  • Physiology
  • Insect Science

Cite this

The Fat-Dachsous signaling pathway regulates growth of horns in Trypoxylus dichotomus, but does not affect horn allometry. / Hust, James; Lavine, Mark D.; Worthington, Amy; Zinna, Robert; Gotoh, Hiroki; Niimi, T.; Lavine, Laura.

In: Journal of Insect Physiology, Vol. 105, 01.02.2018, p. 85-94.

Research output: Contribution to journalArticle

Hust, James ; Lavine, Mark D. ; Worthington, Amy ; Zinna, Robert ; Gotoh, Hiroki ; Niimi, T. ; Lavine, Laura. / The Fat-Dachsous signaling pathway regulates growth of horns in Trypoxylus dichotomus, but does not affect horn allometry. In: Journal of Insect Physiology. 2018 ; Vol. 105. pp. 85-94.
@article{f2f3295ba8cf4ad18dfdfedab761fa33,
title = "The Fat-Dachsous signaling pathway regulates growth of horns in Trypoxylus dichotomus, but does not affect horn allometry",
abstract = "Males of the Asian rhinoceros beetle, Trypoxylus dichotomus, possess exaggerated head and thoracic horns that scale dramatically out of proportion to body size. While studies of insulin signaling suggest that this pathway regulates nutrition-dependent growth including exaggerated horns, what regulates disproportionate growth has yet to be identified. The Fat signaling pathway is a potential candidate for regulating disproportionate growth of sexually-selected traits, a hypothesis we advanced in a previous paper (Gotoh et al., 2015). To investigate the role of Fat signaling in the growth and scaling of the sexually dimorphic, condition-dependent traits of the in the Asian rhinoceros beetle T. dichotomus, we used RNA interference to knock down expression of fat and its co-receptor dachsous. Knockdown of fat, and to a lesser degree dachsous, caused shortening and widening of appendages, including the head and thoracic horns. However, scaling of horns to body size was not affected. Our results show that Fat signaling regulates horn growth in T. dichotomus as it does in appendage growth in other insects. However, we provide evidence that Fat signaling does not mediate the disproportionate, positive allometric growth of horns in T. dichotomus.",
author = "James Hust and Lavine, {Mark D.} and Amy Worthington and Robert Zinna and Hiroki Gotoh and T. Niimi and Laura Lavine",
year = "2018",
month = "2",
day = "1",
doi = "10.1016/j.jinsphys.2018.01.006",
language = "English (US)",
volume = "105",
pages = "85--94",
journal = "Journal of Insect Physiology",
issn = "0022-1910",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - The Fat-Dachsous signaling pathway regulates growth of horns in Trypoxylus dichotomus, but does not affect horn allometry

AU - Hust, James

AU - Lavine, Mark D.

AU - Worthington, Amy

AU - Zinna, Robert

AU - Gotoh, Hiroki

AU - Niimi, T.

AU - Lavine, Laura

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Males of the Asian rhinoceros beetle, Trypoxylus dichotomus, possess exaggerated head and thoracic horns that scale dramatically out of proportion to body size. While studies of insulin signaling suggest that this pathway regulates nutrition-dependent growth including exaggerated horns, what regulates disproportionate growth has yet to be identified. The Fat signaling pathway is a potential candidate for regulating disproportionate growth of sexually-selected traits, a hypothesis we advanced in a previous paper (Gotoh et al., 2015). To investigate the role of Fat signaling in the growth and scaling of the sexually dimorphic, condition-dependent traits of the in the Asian rhinoceros beetle T. dichotomus, we used RNA interference to knock down expression of fat and its co-receptor dachsous. Knockdown of fat, and to a lesser degree dachsous, caused shortening and widening of appendages, including the head and thoracic horns. However, scaling of horns to body size was not affected. Our results show that Fat signaling regulates horn growth in T. dichotomus as it does in appendage growth in other insects. However, we provide evidence that Fat signaling does not mediate the disproportionate, positive allometric growth of horns in T. dichotomus.

AB - Males of the Asian rhinoceros beetle, Trypoxylus dichotomus, possess exaggerated head and thoracic horns that scale dramatically out of proportion to body size. While studies of insulin signaling suggest that this pathway regulates nutrition-dependent growth including exaggerated horns, what regulates disproportionate growth has yet to be identified. The Fat signaling pathway is a potential candidate for regulating disproportionate growth of sexually-selected traits, a hypothesis we advanced in a previous paper (Gotoh et al., 2015). To investigate the role of Fat signaling in the growth and scaling of the sexually dimorphic, condition-dependent traits of the in the Asian rhinoceros beetle T. dichotomus, we used RNA interference to knock down expression of fat and its co-receptor dachsous. Knockdown of fat, and to a lesser degree dachsous, caused shortening and widening of appendages, including the head and thoracic horns. However, scaling of horns to body size was not affected. Our results show that Fat signaling regulates horn growth in T. dichotomus as it does in appendage growth in other insects. However, we provide evidence that Fat signaling does not mediate the disproportionate, positive allometric growth of horns in T. dichotomus.

UR - http://www.scopus.com/inward/record.url?scp=85041421790&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041421790&partnerID=8YFLogxK

U2 - 10.1016/j.jinsphys.2018.01.006

DO - 10.1016/j.jinsphys.2018.01.006

M3 - Article

VL - 105

SP - 85

EP - 94

JO - Journal of Insect Physiology

JF - Journal of Insect Physiology

SN - 0022-1910

ER -