The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21

Patricia Tonin; Olga Serova; Jacques Simard; Gilbert Lenoir; Jean Feunteun; Kenneth Morgan; Henry Lynch; Steven Narod

doi:10.1093/hmg/3.9.1679

The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21

Patricia Tonin, Olga Serova, Jacques Simard, Gilbert Lenoir, Jean Feunteun, Kenneth Morgan, Henry Lynch, Steven Narod

Department of Preventive Medicine

Research output: Contribution to journal › Article

15 Scopus citations

Abstract

A gene for hereditary breast and ovarian cancer, BRCA1, has been mapped to chromosome 17q12-q21. This gene is responsible for cancer susceptibility in the majority of families with multiple cases of ovarian cancer and early-onset breast cancer. We report linkage results of a family with 10 cases of breast cancer and a single case of ovarian cancer. A recombinant event in this family places BRCA1 distal (telomeric) to the locus EDH17B2, which codes for the enzyme estradiol 17β-dehydrogenase II. This recombinant is based on the appearance of breast cancer in a 45 year old woman. Under our genetic model, we estimate the probability that this woman carries a BRCA1 mutation to be 94%. These data further reduce the region of assignment of BRCA1 on chromosome 17q12-q21 and should expedite positional cloning of this important gene.

Original language	English (US)
Pages (from-to)	1679-1682
Number of pages	4
Journal	Human Molecular Genetics
Volume	3
Issue number	9
DOIs	https://doi.org/10.1093/hmg/3.9.1679
State	Published - Sep 1 1994

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics
Genetics(clinical)

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title = "The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21",

abstract = "A gene for hereditary breast and ovarian cancer, BRCA1, has been mapped to chromosome 17q12-q21. This gene is responsible for cancer susceptibility in the majority of families with multiple cases of ovarian cancer and early-onset breast cancer. We report linkage results of a family with 10 cases of breast cancer and a single case of ovarian cancer. A recombinant event in this family places BRCA1 distal (telomeric) to the locus EDH17B2, which codes for the enzyme estradiol 17β-dehydrogenase II. This recombinant is based on the appearance of breast cancer in a 45 year old woman. Under our genetic model, we estimate the probability that this woman carries a BRCA1 mutation to be 94%. These data further reduce the region of assignment of BRCA1 on chromosome 17q12-q21 and should expedite positional cloning of this important gene.",

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AU - Tonin, Patricia

AU - Serova, Olga

AU - Simard, Jacques

AU - Lenoir, Gilbert

AU - Feunteun, Jean

AU - Morgan, Kenneth

AU - Lynch, Henry

AU - Narod, Steven

PY - 1994/9/1

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AB - A gene for hereditary breast and ovarian cancer, BRCA1, has been mapped to chromosome 17q12-q21. This gene is responsible for cancer susceptibility in the majority of families with multiple cases of ovarian cancer and early-onset breast cancer. We report linkage results of a family with 10 cases of breast cancer and a single case of ovarian cancer. A recombinant event in this family places BRCA1 distal (telomeric) to the locus EDH17B2, which codes for the enzyme estradiol 17β-dehydrogenase II. This recombinant is based on the appearance of breast cancer in a 45 year old woman. Under our genetic model, we estimate the probability that this woman carries a BRCA1 mutation to be 94%. These data further reduce the region of assignment of BRCA1 on chromosome 17q12-q21 and should expedite positional cloning of this important gene.

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