Abstract
A gene for hereditary breast and ovarian cancer, BRCA1, has been mapped to chromosome 17q12-q21. This gene is responsible for cancer susceptibility in the majority of families with multiple cases of ovarian cancer and early-onset breast cancer. We report linkage results of a family with 10 cases of breast cancer and a single case of ovarian cancer. A recombinant event in this family places BRCA1 distal (telomeric) to the locus EDH17B2, which codes for the enzyme estradiol 17β-dehydrogenase II. This recombinant is based on the appearance of breast cancer in a 45 year old woman. Under our genetic model, we estimate the probability that this woman carries a BRCA1 mutation to be 94%. These data further reduce the region of assignment of BRCA1 on chromosome 17q12-q21 and should expedite positional cloning of this important gene.
| Original language | English |
|---|---|
| Pages (from-to) | 1679-1682 |
| Number of pages | 4 |
| Journal | Human Molecular Genetics |
| Volume | 3 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1994 |
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All Science Journal Classification (ASJC) codes
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Public Health, Environmental and Occupational Health
- Molecular Biology
- Genetics(clinical)
- Genetics
Cite this
The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21. / Tonin, Patricia; Serova, Olga; Simard, Jacques; Lenoir, Gilbert; Feunteun, Jean; Morgan, Kenneth; Lynch, Henry T.; Narod, Steven.
In: Human Molecular Genetics, Vol. 3, No. 9, 09.1994, p. 1679-1682.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21
AU - Tonin, Patricia
AU - Serova, Olga
AU - Simard, Jacques
AU - Lenoir, Gilbert
AU - Feunteun, Jean
AU - Morgan, Kenneth
AU - Lynch, Henry T.
AU - Narod, Steven
PY - 1994/9
Y1 - 1994/9
N2 - A gene for hereditary breast and ovarian cancer, BRCA1, has been mapped to chromosome 17q12-q21. This gene is responsible for cancer susceptibility in the majority of families with multiple cases of ovarian cancer and early-onset breast cancer. We report linkage results of a family with 10 cases of breast cancer and a single case of ovarian cancer. A recombinant event in this family places BRCA1 distal (telomeric) to the locus EDH17B2, which codes for the enzyme estradiol 17β-dehydrogenase II. This recombinant is based on the appearance of breast cancer in a 45 year old woman. Under our genetic model, we estimate the probability that this woman carries a BRCA1 mutation to be 94%. These data further reduce the region of assignment of BRCA1 on chromosome 17q12-q21 and should expedite positional cloning of this important gene.
AB - A gene for hereditary breast and ovarian cancer, BRCA1, has been mapped to chromosome 17q12-q21. This gene is responsible for cancer susceptibility in the majority of families with multiple cases of ovarian cancer and early-onset breast cancer. We report linkage results of a family with 10 cases of breast cancer and a single case of ovarian cancer. A recombinant event in this family places BRCA1 distal (telomeric) to the locus EDH17B2, which codes for the enzyme estradiol 17β-dehydrogenase II. This recombinant is based on the appearance of breast cancer in a 45 year old woman. Under our genetic model, we estimate the probability that this woman carries a BRCA1 mutation to be 94%. These data further reduce the region of assignment of BRCA1 on chromosome 17q12-q21 and should expedite positional cloning of this important gene.
UR - http://www.scopus.com/inward/record.url?scp=0027968261&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027968261&partnerID=8YFLogxK
U2 - 10.1093/hmg/3.9.1679
DO - 10.1093/hmg/3.9.1679
M3 - Article
C2 - 7833928
AN - SCOPUS:0027968261
VL - 3
SP - 1679
EP - 1682
JO - Human Molecular Genetics
JF - Human Molecular Genetics
SN - 0964-6906
IS - 9
ER -