The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21

Patricia Tonin, Olga Serova, Jacques Simard, Gilbert Lenoir, Jean Feunteun, Kenneth Morgan, Henry T. Lynch, Steven Narod

Research output: Contribution to journalArticle

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Abstract

A gene for hereditary breast and ovarian cancer, BRCA1, has been mapped to chromosome 17q12-q21. This gene is responsible for cancer susceptibility in the majority of families with multiple cases of ovarian cancer and early-onset breast cancer. We report linkage results of a family with 10 cases of breast cancer and a single case of ovarian cancer. A recombinant event in this family places BRCA1 distal (telomeric) to the locus EDH17B2, which codes for the enzyme estradiol 17β-dehydrogenase II. This recombinant is based on the appearance of breast cancer in a 45 year old woman. Under our genetic model, we estimate the probability that this woman carries a BRCA1 mutation to be 94%. These data further reduce the region of assignment of BRCA1 on chromosome 17q12-q21 and should expedite positional cloning of this important gene.

Original languageEnglish
Pages (from-to)1679-1682
Number of pages4
JournalHuman Molecular Genetics
Volume3
Issue number9
DOIs
StatePublished - Sep 1994

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Ovarian Cancer
Chromosomes
Breast Cancer
Ovarian Neoplasms
Chromosome
Genes
Breast Neoplasms
Gene
Estradiol Dehydrogenases
Cloning
Estradiol
Genetic Models
Enzymes
Linkage
Susceptibility
Locus
Organism Cloning
Cancer
Mutation
Assignment

All Science Journal Classification (ASJC) codes

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Public Health, Environmental and Occupational Health
  • Molecular Biology
  • Genetics(clinical)
  • Genetics

Cite this

Tonin, P., Serova, O., Simard, J., Lenoir, G., Feunteun, J., Morgan, K., ... Narod, S. (1994). The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21. Human Molecular Genetics, 3(9), 1679-1682. https://doi.org/10.1093/hmg/3.9.1679

The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21. / Tonin, Patricia; Serova, Olga; Simard, Jacques; Lenoir, Gilbert; Feunteun, Jean; Morgan, Kenneth; Lynch, Henry T.; Narod, Steven.

In: Human Molecular Genetics, Vol. 3, No. 9, 09.1994, p. 1679-1682.

Research output: Contribution to journalArticle

Tonin, P, Serova, O, Simard, J, Lenoir, G, Feunteun, J, Morgan, K, Lynch, HT & Narod, S 1994, 'The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21', Human Molecular Genetics, vol. 3, no. 9, pp. 1679-1682. https://doi.org/10.1093/hmg/3.9.1679
Tonin, Patricia ; Serova, Olga ; Simard, Jacques ; Lenoir, Gilbert ; Feunteun, Jean ; Morgan, Kenneth ; Lynch, Henry T. ; Narod, Steven. / The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21. In: Human Molecular Genetics. 1994 ; Vol. 3, No. 9. pp. 1679-1682.
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