The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21

Patricia Tonin, Olga Serova, Jacques Simard, Gilbert Lenoir, Jean Feunteun, Kenneth Morgan, Henry Lynch, Steven Narod

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Abstract

A gene for hereditary breast and ovarian cancer, BRCA1, has been mapped to chromosome 17q12-q21. This gene is responsible for cancer susceptibility in the majority of families with multiple cases of ovarian cancer and early-onset breast cancer. We report linkage results of a family with 10 cases of breast cancer and a single case of ovarian cancer. A recombinant event in this family places BRCA1 distal (telomeric) to the locus EDH17B2, which codes for the enzyme estradiol 17β-dehydrogenase II. This recombinant is based on the appearance of breast cancer in a 45 year old woman. Under our genetic model, we estimate the probability that this woman carries a BRCA1 mutation to be 94%. These data further reduce the region of assignment of BRCA1 on chromosome 17q12-q21 and should expedite positional cloning of this important gene.

Original languageEnglish (US)
Pages (from-to)1679-1682
Number of pages4
JournalHuman Molecular Genetics
Volume3
Issue number9
DOIs
StatePublished - Sep 1 1994

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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    Tonin, P., Serova, O., Simard, J., Lenoir, G., Feunteun, J., Morgan, K., Lynch, H., & Narod, S. (1994). The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21. Human Molecular Genetics, 3(9), 1679-1682. https://doi.org/10.1093/hmg/3.9.1679