The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21

Patricia Tonin; Olga Serova; Jacques Simard; Gilbert Lenoir; Jean Feunteun; Kenneth Morgan; Henry T. Lynch; Steven Narod

doi:10.1093/hmg/3.9.1679

The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21

Patricia Tonin, Olga Serova, Jacques Simard, Gilbert Lenoir, Jean Feunteun, Kenneth Morgan, Henry T. Lynch, Steven Narod

Department of Preventive Medicine

14 Scopus citations

Abstract

A gene for hereditary breast and ovarian cancer, BRCA1, has been mapped to chromosome 17q12-q21. This gene is responsible for cancer susceptibility in the majority of families with multiple cases of ovarian cancer and early-onset breast cancer. We report linkage results of a family with 10 cases of breast cancer and a single case of ovarian cancer. A recombinant event in this family places BRCA1 distal (telomeric) to the locus EDH17B2, which codes for the enzyme estradiol 17β-dehydrogenase II. This recombinant is based on the appearance of breast cancer in a 45 year old woman. Under our genetic model, we estimate the probability that this woman carries a BRCA1 mutation to be 94%. These data further reduce the region of assignment of BRCA1 on chromosome 17q12-q21 and should expedite positional cloning of this important gene.

Original language	English
Pages (from-to)	1679-1682
Number of pages	4
Journal	Human Molecular Genetics
Volume	3
Issue number	9
DOIs	https://doi.org/10.1093/hmg/3.9.1679
Publication status	Published - Sep 1994

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All Science Journal Classification (ASJC) codes

Statistics, Probability and Uncertainty
Applied Mathematics
Public Health, Environmental and Occupational Health
Molecular Biology
Genetics(clinical)
Genetics

Cite this

Tonin, P., Serova, O., Simard, J., Lenoir, G., Feunteun, J., Morgan, K., ... Narod, S. (1994). The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21. Human Molecular Genetics, 3(9), 1679-1682. https://doi.org/10.1093/hmg/3.9.1679

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10.1093/hmg/3.9.1679