The genetics of osteoporosis

Ji Rong Long, Dong Hai Xiong, Robert R. Recker, Hong Wen Deng

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Osteoporosis is a common health problem among the elderly, especially postmenopausal women. It is characterized by fragile bones susceptible to low-trauma fractures. Osteoporosis is a complex disease determined by genetic and environmental factors, as well as the possible interactions among these factors. Twin and family studies have shown that genetic factors play an important role in Osteoporosis. Numerous genetic studies have been performed to hunt for genes underlying the disease risk. In this review, we briefly summarize and discuss the current status of knowledge about osteoporosis, with special emphasis on the progress achieved recently in: 1) heritability and choice of osteoporosis study phenotypes; 2) the approaches for gene mapping and identification for osteoporosis; 3) the candidate gene association studies; 4) the linkage mapping studies for osteoporosis; 5) some potential explanations for the inconsistent results; and 6) the pharmacogenetic studies for osteoporosis.

Original languageEnglish
Pages (from-to)205-218
Number of pages14
JournalDrugs of Today
Volume41
Issue number3
DOIs
StatePublished - Mar 2005

Fingerprint

Osteoporosis
Chromosome Mapping
Inborn Genetic Diseases
Twin Studies
Genetic Association Studies
Phenotype
Bone and Bones
Health
Wounds and Injuries
Genes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology (medical)
  • Pharmacology

Cite this

Long, J. R., Xiong, D. H., Recker, R. R., & Deng, H. W. (2005). The genetics of osteoporosis. Drugs of Today, 41(3), 205-218. https://doi.org/10.1358/dot.2005.41.3.892525

The genetics of osteoporosis. / Long, Ji Rong; Xiong, Dong Hai; Recker, Robert R.; Deng, Hong Wen.

In: Drugs of Today, Vol. 41, No. 3, 03.2005, p. 205-218.

Research output: Contribution to journalReview article

Long, JR, Xiong, DH, Recker, RR & Deng, HW 2005, 'The genetics of osteoporosis', Drugs of Today, vol. 41, no. 3, pp. 205-218. https://doi.org/10.1358/dot.2005.41.3.892525
Long, Ji Rong ; Xiong, Dong Hai ; Recker, Robert R. ; Deng, Hong Wen. / The genetics of osteoporosis. In: Drugs of Today. 2005 ; Vol. 41, No. 3. pp. 205-218.
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