The globus pallidus receives a projection from the parafascicular nucleus in the rat

Anthony E. Kincaid, John B. Penney, Anne B. Young, Sarah W. Newman

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Study of the afferents of the rat globus pallidus (GP) with Fluoro-gold, a retrograde tracer, revealed retrogradely labeled neurons in the ipsilateral parafascicular nucleus of the thalamus (PF), a previously undescribed afferent of the rat GP. We used the anterograde tracer, Phaseolus vulgaris-leucoagglutinin (PHA-L), to confirm and extend our findings. After injections of PHA-L in the PF, labeled fibers with varicosities and terminal specializations were observed in the ipsilateral GP. The topographical organization of the projection is such that lateral and ventral PF neurons project preferentially to respective parts of the GP, and medial PF neurons project primarily to the ventral GP. There were very few labeled fibers seen in the dorsal or medial GP. The presently described projection from the PF to the GP provides an additional route for the PF to influence basal ganglia circuitry.

Original languageEnglish (US)
Pages (from-to)18-26
Number of pages9
JournalBrain Research
Volume553
Issue number1
DOIs
StatePublished - Jul 5 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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