The hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation

M. Rendell; Y. Salomon; M. C. Lin; M. Rodbell; M. Berman

The hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation

M. Rendell, Y. Salomon, M. C. Lin, M. Rodbell, M. Berman

Department of Medicine

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

A steady state kinetic model for hepatic adenylate cyclase is presented. The activity of the enzyme was assayed in the presence of a range of concentrations of magnesium, adenylylimidodiphosphate, 5' guanylylimidodiphosphate, and in the presence and absence of saturating concentrations of glucagon. The data were tested against proposed models using an iterative least squares curve fitting program and confidence estimates for the model parameters were obtained.

Original language	English (US)
Pages (from-to)	4253-4260
Number of pages	8
Journal	Journal of Biological Chemistry
Volume	250
Issue number	11
State	Published - Dec 1 1975

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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title = "The hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation",

abstract = "A steady state kinetic model for hepatic adenylate cyclase is presented. The activity of the enzyme was assayed in the presence of a range of concentrations of magnesium, adenylylimidodiphosphate, 5' guanylylimidodiphosphate, and in the presence and absence of saturating concentrations of glucagon. The data were tested against proposed models using an iterative least squares curve fitting program and confidence estimates for the model parameters were obtained.",

author = "M. Rendell and Y. Salomon and Lin, {M. C.} and M. Rodbell and M. Berman",

year = "1975",

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T1 - The hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation

AU - Rendell, M.

AU - Salomon, Y.

AU - Lin, M. C.

AU - Rodbell, M.

AU - Berman, M.

PY - 1975/12/1

Y1 - 1975/12/1

N2 - A steady state kinetic model for hepatic adenylate cyclase is presented. The activity of the enzyme was assayed in the presence of a range of concentrations of magnesium, adenylylimidodiphosphate, 5' guanylylimidodiphosphate, and in the presence and absence of saturating concentrations of glucagon. The data were tested against proposed models using an iterative least squares curve fitting program and confidence estimates for the model parameters were obtained.

AB - A steady state kinetic model for hepatic adenylate cyclase is presented. The activity of the enzyme was assayed in the presence of a range of concentrations of magnesium, adenylylimidodiphosphate, 5' guanylylimidodiphosphate, and in the presence and absence of saturating concentrations of glucagon. The data were tested against proposed models using an iterative least squares curve fitting program and confidence estimates for the model parameters were obtained.

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