Abstract
A steady state kinetic model for hepatic adenylate cyclase is presented. The activity of the enzyme was assayed in the presence of a range of concentrations of magnesium, adenylylimidodiphosphate, 5' guanylylimidodiphosphate, and in the presence and absence of saturating concentrations of glucagon. The data were tested against proposed models using an iterative least squares curve fitting program and confidence estimates for the model parameters were obtained.
| Original language | English |
|---|---|
| Pages (from-to) | 4253-4260 |
| Number of pages | 8 |
| Journal | Journal of Biological Chemistry |
| Volume | 250 |
| Issue number | 11 |
| State | Published - 1975 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Biochemistry
Cite this
The hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation. / Rendell, M.; Salomon, Y.; Lin, M. C.; Rodbell, M.; Berman, M.
In: Journal of Biological Chemistry, Vol. 250, No. 11, 1975, p. 4253-4260.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation
AU - Rendell, M.
AU - Salomon, Y.
AU - Lin, M. C.
AU - Rodbell, M.
AU - Berman, M.
PY - 1975
Y1 - 1975
N2 - A steady state kinetic model for hepatic adenylate cyclase is presented. The activity of the enzyme was assayed in the presence of a range of concentrations of magnesium, adenylylimidodiphosphate, 5' guanylylimidodiphosphate, and in the presence and absence of saturating concentrations of glucagon. The data were tested against proposed models using an iterative least squares curve fitting program and confidence estimates for the model parameters were obtained.
AB - A steady state kinetic model for hepatic adenylate cyclase is presented. The activity of the enzyme was assayed in the presence of a range of concentrations of magnesium, adenylylimidodiphosphate, 5' guanylylimidodiphosphate, and in the presence and absence of saturating concentrations of glucagon. The data were tested against proposed models using an iterative least squares curve fitting program and confidence estimates for the model parameters were obtained.
UR - http://www.scopus.com/inward/record.url?scp=0016705577&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016705577&partnerID=8YFLogxK
M3 - Article
VL - 250
SP - 4253
EP - 4260
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 11
ER -