The Human Insulin-like Growth Factor-Binding Protein 4 Gene Maps to Chromosome Region 17q12-q21.1 and Is Close to the Gene for Hereditary Breast-Ovarian Cancer

Patricia Tonin, Ewa Ehrenborg, Gilbert Lenoir, Jean Feunteun, Henry T. Lynch, Kenneth Morgan, Henric Zazzi, Anne Vivier, Michael Pollak, Hung Huynh, Holgar Luthman, Catharina Larsson, Steven Narod

Research output: Contribution to journalArticle

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Abstract

The gene for insulin-like growth factor-binding protein 4 (IGFBP4) codes for a serum protein that binds to the family of insulin-like growth factors and modulates their activity. It has been mapped by in situ hybridization to chromosome region 17q12-q21.1. We have developed a CA-repeat polymorphism from a cosmid clone containing IGFBP4. By linkage analysis, IGFBP4 maps to the chromosome 17q interval THRA1-D17S579. This interval also contains the gene for hereditary breast-ovarian cancer, BRCA1. Genetic recombination between IGFBP4 and BRCA1 places IGFBP4 centromeric to the cancer susceptibility gene and effectively excludes it as a candidate gene for BRCA1. IGFBP4 is, however, one of the closest known centromeric markers for BRCA1; the estimated recombination fraction is 0.015. IGFBP4 and D17S579 together define a 2.8-cM interval that contains BRCA1.

Original languageEnglish
Pages (from-to)414-417
Number of pages4
JournalGenomics
Volume18
Issue number2
DOIs
StatePublished - Nov 1993

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Insulin-Like Growth Factor Binding Protein 4
Ovarian Neoplasms
Chromosomes
Breast Neoplasms
Genes
Genetic Recombination
BRCA1 Gene
Cosmids
Neoplasm Genes
Somatomedins
In Situ Hybridization
Blood Proteins
Clone Cells

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

The Human Insulin-like Growth Factor-Binding Protein 4 Gene Maps to Chromosome Region 17q12-q21.1 and Is Close to the Gene for Hereditary Breast-Ovarian Cancer. / Tonin, Patricia; Ehrenborg, Ewa; Lenoir, Gilbert; Feunteun, Jean; Lynch, Henry T.; Morgan, Kenneth; Zazzi, Henric; Vivier, Anne; Pollak, Michael; Huynh, Hung; Luthman, Holgar; Larsson, Catharina; Narod, Steven.

In: Genomics, Vol. 18, No. 2, 11.1993, p. 414-417.

Research output: Contribution to journalArticle

Tonin, P, Ehrenborg, E, Lenoir, G, Feunteun, J, Lynch, HT, Morgan, K, Zazzi, H, Vivier, A, Pollak, M, Huynh, H, Luthman, H, Larsson, C & Narod, S 1993, 'The Human Insulin-like Growth Factor-Binding Protein 4 Gene Maps to Chromosome Region 17q12-q21.1 and Is Close to the Gene for Hereditary Breast-Ovarian Cancer', Genomics, vol. 18, no. 2, pp. 414-417. https://doi.org/10.1006/geno.1993.1487
Tonin, Patricia ; Ehrenborg, Ewa ; Lenoir, Gilbert ; Feunteun, Jean ; Lynch, Henry T. ; Morgan, Kenneth ; Zazzi, Henric ; Vivier, Anne ; Pollak, Michael ; Huynh, Hung ; Luthman, Holgar ; Larsson, Catharina ; Narod, Steven. / The Human Insulin-like Growth Factor-Binding Protein 4 Gene Maps to Chromosome Region 17q12-q21.1 and Is Close to the Gene for Hereditary Breast-Ovarian Cancer. In: Genomics. 1993 ; Vol. 18, No. 2. pp. 414-417.
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abstract = "The gene for insulin-like growth factor-binding protein 4 (IGFBP4) codes for a serum protein that binds to the family of insulin-like growth factors and modulates their activity. It has been mapped by in situ hybridization to chromosome region 17q12-q21.1. We have developed a CA-repeat polymorphism from a cosmid clone containing IGFBP4. By linkage analysis, IGFBP4 maps to the chromosome 17q interval THRA1-D17S579. This interval also contains the gene for hereditary breast-ovarian cancer, BRCA1. Genetic recombination between IGFBP4 and BRCA1 places IGFBP4 centromeric to the cancer susceptibility gene and effectively excludes it as a candidate gene for BRCA1. IGFBP4 is, however, one of the closest known centromeric markers for BRCA1; the estimated recombination fraction is 0.015. IGFBP4 and D17S579 together define a 2.8-cM interval that contains BRCA1.",
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