The Human Insulin-like Growth Factor-Binding Protein 4 Gene Maps to Chromosome Region 17q12-q21.1 and Is Close to the Gene for Hereditary Breast-Ovarian Cancer

Patricia Tonin, Ewa Ehrenborg, Gilbert Lenoir, Jean Feunteun, Henry Lynch, Kenneth Morgan, Henric Zazzi, Anne Vivier, Michael Pollak, Hung Huynh, Holgar Luthman, Catharina Larsson, Steven Narod

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The gene for insulin-like growth factor-binding protein 4 (IGFBP4) codes for a serum protein that binds to the family of insulin-like growth factors and modulates their activity. It has been mapped by in situ hybridization to chromosome region 17q12-q21.1. We have developed a CA-repeat polymorphism from a cosmid clone containing IGFBP4. By linkage analysis, IGFBP4 maps to the chromosome 17q interval THRA1-D17S579. This interval also contains the gene for hereditary breast-ovarian cancer, BRCA1. Genetic recombination between IGFBP4 and BRCA1 places IGFBP4 centromeric to the cancer susceptibility gene and effectively excludes it as a candidate gene for BRCA1. IGFBP4 is, however, one of the closest known centromeric markers for BRCA1; the estimated recombination fraction is 0.015. IGFBP4 and D17S579 together define a 2.8-cM interval that contains BRCA1.

Original languageEnglish (US)
Pages (from-to)414-417
Number of pages4
JournalGenomics
Volume18
Issue number2
DOIs
StatePublished - Nov 1993

All Science Journal Classification (ASJC) codes

  • Genetics

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