The I1307K APC polymorphism in Ashkenazi Jews with colorectal cancer

clinical and pathologic features

Gershon Y. Locker, Karen Kaul, David S. Weinberg, Zoran Gatalica, Gordon Gong, Amy Peterman, Jane Lynch, Lucy Klatzco, Olufunmilayo I. Olopade, Charles A. Bomzer, Anna Newlin, Eileen Keenan, Mohammed Tajuddin, Joseph Knezetic, Stephanie Coronel, Henry T. Lynch

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Colorectal cancer is common in Ashkenazi Jews. The I1307K APC mutation occurs in 6-7% of Ashkenazi Jews and increases the risk of colorectal cancer. This study aimed to describe the clinical, pathologic and epidemiologic features of colorectal cancer in I1307K carriers to determine whether there were any features which might warrant individual screening for the mutation. In all, 215 Ashkenazi Jews with a personal history of colorectal cancer were enrolled. Clinical and family history, pathology reports, and slides were obtained and blood drawn for I1307K determination. The presence of the mutation was determined by PCR from white blood cell DNA. Colorectal cancer pathology slides were read in a blinded fashion. Of the 215 enrolled patients, 26 (12.1%) tested positive for I1307K. There was no difference in the pathologic features between colorectal cancers in Ashkenazi carriers compared to noncarriers. There was no difference in the age at diagnosis or history of second or other primaries. Carriers had an increased likelihood of having a first-degree relative with colorectal cancer (50%) compared to noncarriers (28%, P <0.04). We could find no distinguishing feature other than family history that characterizes I1307K positive colorectal cancers. We could find no group of Ashkenazi Jews with colorectal cancer for whom screening for I1307K would be clinically useful.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume169
Issue number1
DOIs
StatePublished - Aug 2006

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Jews
Colorectal Neoplasms
Mutation
Pathology
Early Detection of Cancer
Leukocytes
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

The I1307K APC polymorphism in Ashkenazi Jews with colorectal cancer : clinical and pathologic features. / Locker, Gershon Y.; Kaul, Karen; Weinberg, David S.; Gatalica, Zoran; Gong, Gordon; Peterman, Amy; Lynch, Jane; Klatzco, Lucy; Olopade, Olufunmilayo I.; Bomzer, Charles A.; Newlin, Anna; Keenan, Eileen; Tajuddin, Mohammed; Knezetic, Joseph; Coronel, Stephanie; Lynch, Henry T.

In: Cancer Genetics and Cytogenetics, Vol. 169, No. 1, 08.2006, p. 33-38.

Research output: Contribution to journalArticle

Locker, GY, Kaul, K, Weinberg, DS, Gatalica, Z, Gong, G, Peterman, A, Lynch, J, Klatzco, L, Olopade, OI, Bomzer, CA, Newlin, A, Keenan, E, Tajuddin, M, Knezetic, J, Coronel, S & Lynch, HT 2006, 'The I1307K APC polymorphism in Ashkenazi Jews with colorectal cancer: clinical and pathologic features', Cancer Genetics and Cytogenetics, vol. 169, no. 1, pp. 33-38. https://doi.org/10.1016/j.cancergencyto.2006.03.007
Locker, Gershon Y. ; Kaul, Karen ; Weinberg, David S. ; Gatalica, Zoran ; Gong, Gordon ; Peterman, Amy ; Lynch, Jane ; Klatzco, Lucy ; Olopade, Olufunmilayo I. ; Bomzer, Charles A. ; Newlin, Anna ; Keenan, Eileen ; Tajuddin, Mohammed ; Knezetic, Joseph ; Coronel, Stephanie ; Lynch, Henry T. / The I1307K APC polymorphism in Ashkenazi Jews with colorectal cancer : clinical and pathologic features. In: Cancer Genetics and Cytogenetics. 2006 ; Vol. 169, No. 1. pp. 33-38.
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