@article{7fa7c6c506f9499a91687006e317e3be,
title = "The impact of COVID-19 on clinical outcomes among acute myocardial infarction patients undergoing early invasive treatment strategy",
abstract = "Background: The implications of coronavirus disease 2019 (COVID-19) infection on outcomes after invasive therapeutic strategies among patients presenting with acute myocardial infarction (AMI) are not well studied. Hypothesis: To assess the outcomes of COVID-19 patients presenting with AMI undergoing an early invasive treatment strategy. Methods: This study was a cross-sectional, retrospective analysis of the National COVID Cohort Collaborative database including all patients presenting with a recorded diagnosis of AMI (ST-elevation myocardial infarction (MI) and non-ST elevation MI). COVID-19 positive patients with AMI were stratified into one of four groups: (1a) patients who had a coronary angiogram with percutaneous coronary intervention (PCI) within 3 days of their AMI; (1b) PCI within 3 days of AMI with coronary artery bypass graft (CABG) within 30 days; (2a) coronary angiogram without PCI and without CABG within 30 days; and (2b) coronary angiogram with CABG within 30 days. The main outcomes were respiratory failure, cardiogenic shock, prolonged length of stay, rehospitalization, and death. Results: There were 10 506 COVID-19 positive patients with a diagnosis of AMI. COVID-19 positive patients with PCI had 8.2 times higher odds of respiratory failure than COVID-19 negative patients (p =.001). The odds of prolonged length of stay were 1.7 times higher in COVID-19 patients who underwent PCI (p =.024) and 1.9 times higher in patients who underwent coronary angiogram followed by CABG (p =.001). Conclusion: These data demonstrate that COVID-19 positive patients with AMI undergoing early invasive coronary angiography had worse outcomes than COVID-19 negative patients.",
author = "Prerna Sharma and Kajal Shah and Johanna Loomba and Arti Patel and Indika Mallawaarachchi and Olivia Blazek and Sarah Ratcliffe and Khadijah Breathett and Johnson, {Amber E.} and Taylor, {Angela M.} and Michael Salerno and Michael Ragosta and Nishtha Sodhi and Daniel Addison and Selma Mohammed and Bilchick, {Kenneth C.} and Sula Mazimba",
note = "Funding Information: The analyses described in this (publication/report/presentation) were conducted with data or tools accessed through the NCATS N3C Data Enclave https://covid.cd2h.org and N3C Attribution & Publication Policy v 1.2-2020-08-25b, and supported by NCATS U24 TR002306. Research analytics were supported by the iTHRIV CTSA Informatics BERD cores under NCATS UL1 TR003015. This research was possible because of the patients whose information is included within the data and the organizations and scientists who have contributed to the on-going development of this community resource (https://doi.org/10.1093/jamia/ocaa196). Authorship was determined using ICMJE recommendations. Full guidelines attached. The consortial authors are: Melissa A. Haendel, Center for Health AI, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Funding Information: The analyses described in this (publication/report/presentation) were conducted with data or tools accessed through the NCATS N3C Data Enclave https://covid.cd2h.org and N3C Attribution & Publication Policy v 1.2‐2020‐08‐25b, and supported by NCATS U24 TR002306. Research analytics were supported by the iTHRIV CTSA Informatics BERD cores under NCATS UL1 TR003015. This research was possible because of the patients whose information is included within the data and the organizations and scientists who have contributed to the on‐going development of this community resource ( https://doi.org/10.1093/jamia/ocaa196 ). Authorship was determined using ICMJE recommendations. Full guidelines attached. The consortial authors are: Melissa A. Haendel, Center for Health AI, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Contribution: Involved in funding acquisition; governance; project management; regulatory oversight and administration. Christopher G. Chute, Schools of Medicine, Public Health and Nursing, Johns Hopkins University, Baltimore, MD, USA. Contribution: data curation, data integration, data quality assurance, data security, database/information systems administration, funding acquisition, governance, critical revision of the manuscript for important intellectual content, N3C Phenotype definition, project evaluation, project management, regulatory oversight and administration. Publisher Copyright: {\textcopyright} 2022 The Authors. Clinical Cardiology published by Wiley Periodicals, LLC.",
year = "2022",
month = oct,
doi = "10.1002/clc.23908",
language = "English (US)",
volume = "45",
pages = "1070--1078",
journal = "Clinical Cardiology",
issn = "0160-9289",
publisher = "John Wiley and Sons Inc.",
number = "10",
}