The impact of early flow and brain oxygen crisis on the outcome of patients with severe traumatic brain injury

Corrado P. Marini, Christy Stoller, Omar Shah, Antoni Policastro, Gary Lombardo, Juan A. Asensio, Yin C. Hu, Michael F. Stiefel

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background Multimodality monitoring and goal-directed therapy may not prevent blood flow and brain oxygen (Flow/BrOx) crisis. We sought to determine the impact of these events on outcome in patients with severe traumatic brain injury (sTBI).

Methods Twenty-four patients with sTBI were treated to maintain intracranial pressure (ICP) less than or equal to 20 mm Hg, cerebral perfusion pressure (CPP) greater than or equal to 60 mm Hg, brain oxygen greater than or equal to 20 mm Hg, and near infrared spectroscopy greater than or equal to 60%. Flow/BrOx crisis events were recorded. The 14-day predicted mortality was compared with actual mortality.

Results Nonsurvivors had a significantly higher number of crisis events nonresponsive to treatment (P

Conclusions A multimodality monitoring and goal-directed therapy may decrease mortality in sTBI. However, Flow/BrOx crisis events still occur and predict a poor outcome.

Original languageEnglish
Pages (from-to)1071-1077
Number of pages7
JournalAmerican Journal of Surgery
Volume208
Issue number6
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

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Oxygen
Brain
Mortality
Cerebrovascular Circulation
Near-Infrared Spectroscopy
Intracranial Pressure
Therapeutics
Traumatic Brain Injury

All Science Journal Classification (ASJC) codes

  • Surgery
  • Medicine(all)

Cite this

The impact of early flow and brain oxygen crisis on the outcome of patients with severe traumatic brain injury. / Marini, Corrado P.; Stoller, Christy; Shah, Omar; Policastro, Antoni; Lombardo, Gary; Asensio, Juan A.; Hu, Yin C.; Stiefel, Michael F.

In: American Journal of Surgery, Vol. 208, No. 6, 01.12.2014, p. 1071-1077.

Research output: Contribution to journalArticle

Marini, Corrado P. ; Stoller, Christy ; Shah, Omar ; Policastro, Antoni ; Lombardo, Gary ; Asensio, Juan A. ; Hu, Yin C. ; Stiefel, Michael F. / The impact of early flow and brain oxygen crisis on the outcome of patients with severe traumatic brain injury. In: American Journal of Surgery. 2014 ; Vol. 208, No. 6. pp. 1071-1077.
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AU - Asensio, Juan A.

AU - Hu, Yin C.

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