Abstract
Background Multimodality monitoring and goal-directed therapy may not prevent blood flow and brain oxygen (Flow/BrOx) crisis. We sought to determine the impact of these events on outcome in patients with severe traumatic brain injury (sTBI).
Methods Twenty-four patients with sTBI were treated to maintain intracranial pressure (ICP) less than or equal to 20 mm Hg, cerebral perfusion pressure (CPP) greater than or equal to 60 mm Hg, brain oxygen greater than or equal to 20 mm Hg, and near infrared spectroscopy greater than or equal to 60%. Flow/BrOx crisis events were recorded. The 14-day predicted mortality was compared with actual mortality.
Results Nonsurvivors had a significantly higher number of crisis events nonresponsive to treatment (P
Conclusions A multimodality monitoring and goal-directed therapy may decrease mortality in sTBI. However, Flow/BrOx crisis events still occur and predict a poor outcome.
| Original language | English |
|---|---|
| Pages (from-to) | 1071-1077 |
| Number of pages | 7 |
| Journal | American Journal of Surgery |
| Volume | 208 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 2014 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Surgery
- Medicine(all)
Cite this
The impact of early flow and brain oxygen crisis on the outcome of patients with severe traumatic brain injury. / Marini, Corrado P.; Stoller, Christy; Shah, Omar; Policastro, Antoni; Lombardo, Gary; Asensio, Juan A.; Hu, Yin C.; Stiefel, Michael F.
In: American Journal of Surgery, Vol. 208, No. 6, 01.12.2014, p. 1071-1077.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The impact of early flow and brain oxygen crisis on the outcome of patients with severe traumatic brain injury
AU - Marini, Corrado P.
AU - Stoller, Christy
AU - Shah, Omar
AU - Policastro, Antoni
AU - Lombardo, Gary
AU - Asensio, Juan A.
AU - Hu, Yin C.
AU - Stiefel, Michael F.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Background Multimodality monitoring and goal-directed therapy may not prevent blood flow and brain oxygen (Flow/BrOx) crisis. We sought to determine the impact of these events on outcome in patients with severe traumatic brain injury (sTBI).Methods Twenty-four patients with sTBI were treated to maintain intracranial pressure (ICP) less than or equal to 20 mm Hg, cerebral perfusion pressure (CPP) greater than or equal to 60 mm Hg, brain oxygen greater than or equal to 20 mm Hg, and near infrared spectroscopy greater than or equal to 60%. Flow/BrOx crisis events were recorded. The 14-day predicted mortality was compared with actual mortality.Results Nonsurvivors had a significantly higher number of crisis events nonresponsive to treatment (P Conclusions A multimodality monitoring and goal-directed therapy may decrease mortality in sTBI. However, Flow/BrOx crisis events still occur and predict a poor outcome.
AB - Background Multimodality monitoring and goal-directed therapy may not prevent blood flow and brain oxygen (Flow/BrOx) crisis. We sought to determine the impact of these events on outcome in patients with severe traumatic brain injury (sTBI).Methods Twenty-four patients with sTBI were treated to maintain intracranial pressure (ICP) less than or equal to 20 mm Hg, cerebral perfusion pressure (CPP) greater than or equal to 60 mm Hg, brain oxygen greater than or equal to 20 mm Hg, and near infrared spectroscopy greater than or equal to 60%. Flow/BrOx crisis events were recorded. The 14-day predicted mortality was compared with actual mortality.Results Nonsurvivors had a significantly higher number of crisis events nonresponsive to treatment (P Conclusions A multimodality monitoring and goal-directed therapy may decrease mortality in sTBI. However, Flow/BrOx crisis events still occur and predict a poor outcome.
UR - http://www.scopus.com/inward/record.url?scp=84916618761&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84916618761&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2014.08.003
DO - 10.1016/j.amjsurg.2014.08.003
M3 - Article
VL - 208
SP - 1071
EP - 1077
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 6
ER -