The impact of Vitamin D on asthmatic human airway smooth muscle

Sannette C. Hall, Kimberly D. Fischer, Devendra K. Agrawal

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Asthma is a chronic heterogeneous disorder, which involves airway inflammation, airway hyperresponsiveness (AHR) and airway remodeling. The airway smooth muscle (ASM) bundle regulates the broncho-motor tone and plays a critical role in AHR as well as orchestrating inflammation. Vitamin D deficiency has been linked to increased severity and exacerbations of symptoms in asthmatic patients. It has been shown to modulate both immune and structural cells, including ASM cells, in inflammatory diseases. Given that current asthma therapies have not been successful in reversing airway remodeling, vitamin D supplementation as a potential therapeutic option has gained a great deal of attention. Here, we highlight the potential immunomodulatory properties of vitamin D in regulating ASM function and airway inflammation in bronchial asthma.

Original languageEnglish
Pages (from-to)127-135
Number of pages9
JournalExpert Review of Respiratory Medicine
Volume10
Issue number2
DOIs
StatePublished - Feb 1 2016

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All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Public Health, Environmental and Occupational Health

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