Abstract
Asthma is a chronic heterogeneous disorder, which involves airway inflammation, airway hyperresponsiveness (AHR) and airway remodeling. The airway smooth muscle (ASM) bundle regulates the broncho-motor tone and plays a critical role in AHR as well as orchestrating inflammation. Vitamin D deficiency has been linked to increased severity and exacerbations of symptoms in asthmatic patients. It has been shown to modulate both immune and structural cells, including ASM cells, in inflammatory diseases. Given that current asthma therapies have not been successful in reversing airway remodeling, vitamin D supplementation as a potential therapeutic option has gained a great deal of attention. Here, we highlight the potential immunomodulatory properties of vitamin D in regulating ASM function and airway inflammation in bronchial asthma.
| Original language | English |
|---|---|
| Pages (from-to) | 127-135 |
| Number of pages | 9 |
| Journal | Expert Review of Respiratory Medicine |
| Volume | 10 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2016 |
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All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine
- Immunology and Allergy
- Public Health, Environmental and Occupational Health
Cite this
The impact of Vitamin D on asthmatic human airway smooth muscle. / Hall, Sannette C.; Fischer, Kimberly D.; Agrawal, Devendra K.
In: Expert Review of Respiratory Medicine, Vol. 10, No. 2, 01.02.2016, p. 127-135.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The impact of Vitamin D on asthmatic human airway smooth muscle
AU - Hall, Sannette C.
AU - Fischer, Kimberly D.
AU - Agrawal, Devendra K.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Asthma is a chronic heterogeneous disorder, which involves airway inflammation, airway hyperresponsiveness (AHR) and airway remodeling. The airway smooth muscle (ASM) bundle regulates the broncho-motor tone and plays a critical role in AHR as well as orchestrating inflammation. Vitamin D deficiency has been linked to increased severity and exacerbations of symptoms in asthmatic patients. It has been shown to modulate both immune and structural cells, including ASM cells, in inflammatory diseases. Given that current asthma therapies have not been successful in reversing airway remodeling, vitamin D supplementation as a potential therapeutic option has gained a great deal of attention. Here, we highlight the potential immunomodulatory properties of vitamin D in regulating ASM function and airway inflammation in bronchial asthma.
AB - Asthma is a chronic heterogeneous disorder, which involves airway inflammation, airway hyperresponsiveness (AHR) and airway remodeling. The airway smooth muscle (ASM) bundle regulates the broncho-motor tone and plays a critical role in AHR as well as orchestrating inflammation. Vitamin D deficiency has been linked to increased severity and exacerbations of symptoms in asthmatic patients. It has been shown to modulate both immune and structural cells, including ASM cells, in inflammatory diseases. Given that current asthma therapies have not been successful in reversing airway remodeling, vitamin D supplementation as a potential therapeutic option has gained a great deal of attention. Here, we highlight the potential immunomodulatory properties of vitamin D in regulating ASM function and airway inflammation in bronchial asthma.
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UR - http://www.scopus.com/inward/citedby.url?scp=84957439064&partnerID=8YFLogxK
U2 - 10.1586/17476348.2016.1128326
DO - 10.1586/17476348.2016.1128326
M3 - Review article
AN - SCOPUS:84957439064
VL - 10
SP - 127
EP - 135
JO - Expert Review of Respiratory Medicine
JF - Expert Review of Respiratory Medicine
SN - 1747-6348
IS - 2
ER -