The influence of psychological distress on use of genetic testing for cancer risk

Caryn Lerman, Marc D. Schwartz, Ting Hsiang Lin, Chanita Hughes, Steven Narod, Henry T. Lynch

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

The recent identification of BRCA1, a breast cancer susceptibility gene, offers an unprecedented opportunity for high-risk individuals to learn whether they are genetically predisposed to develop breast or ovarian cancer. This study examined the relationships between psychological distress and use of BRCA1 testing by 149 high-risk individuals from hereditary cancer families. After a baseline assessment of demographics, objective risk, cancer-specific distress, and global distress (depressive symptoms), study participants were offered the opportunity to receive genetic counseling and to learn whether they carry a mutation in the BRCA1 gene. Overall, 58% of study participants requested BRCA1 test results, and 42% declined to learn their genetic status. After controlling for demographic factors and risk status, cancer-specific distress was significantly and positively related to BRCA1 test use, whereas global distress was unrelated to test use.

Original languageEnglish
Pages (from-to)414-420
Number of pages7
JournalJournal of Consulting and Clinical Psychology
Volume65
Issue number3
DOIs
StatePublished - Jun 1997

Fingerprint

Genetic Testing
Psychology
Neoplasms
Demography
Breast Neoplasms
BRCA1 Gene
Neoplasm Genes
Genetic Counseling
Ovarian Neoplasms
Depression
Mutation

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

The influence of psychological distress on use of genetic testing for cancer risk. / Lerman, Caryn; Schwartz, Marc D.; Lin, Ting Hsiang; Hughes, Chanita; Narod, Steven; Lynch, Henry T.

In: Journal of Consulting and Clinical Psychology, Vol. 65, No. 3, 06.1997, p. 414-420.

Research output: Contribution to journalArticle

Lerman, Caryn ; Schwartz, Marc D. ; Lin, Ting Hsiang ; Hughes, Chanita ; Narod, Steven ; Lynch, Henry T. / The influence of psychological distress on use of genetic testing for cancer risk. In: Journal of Consulting and Clinical Psychology. 1997 ; Vol. 65, No. 3. pp. 414-420.
@article{b6b49375e77d4aebb6ac57b1b361ac5f,
title = "The influence of psychological distress on use of genetic testing for cancer risk",
abstract = "The recent identification of BRCA1, a breast cancer susceptibility gene, offers an unprecedented opportunity for high-risk individuals to learn whether they are genetically predisposed to develop breast or ovarian cancer. This study examined the relationships between psychological distress and use of BRCA1 testing by 149 high-risk individuals from hereditary cancer families. After a baseline assessment of demographics, objective risk, cancer-specific distress, and global distress (depressive symptoms), study participants were offered the opportunity to receive genetic counseling and to learn whether they carry a mutation in the BRCA1 gene. Overall, 58{\%} of study participants requested BRCA1 test results, and 42{\%} declined to learn their genetic status. After controlling for demographic factors and risk status, cancer-specific distress was significantly and positively related to BRCA1 test use, whereas global distress was unrelated to test use.",
author = "Caryn Lerman and Schwartz, {Marc D.} and Lin, {Ting Hsiang} and Chanita Hughes and Steven Narod and Lynch, {Henry T.}",
year = "1997",
month = "6",
doi = "10.1037/0022-006X.65.3.414",
language = "English",
volume = "65",
pages = "414--420",
journal = "Journal of Consulting and Clinical Psychology",
issn = "0022-006X",
publisher = "American Psychological Association Inc.",
number = "3",

}

TY - JOUR

T1 - The influence of psychological distress on use of genetic testing for cancer risk

AU - Lerman, Caryn

AU - Schwartz, Marc D.

AU - Lin, Ting Hsiang

AU - Hughes, Chanita

AU - Narod, Steven

AU - Lynch, Henry T.

PY - 1997/6

Y1 - 1997/6

N2 - The recent identification of BRCA1, a breast cancer susceptibility gene, offers an unprecedented opportunity for high-risk individuals to learn whether they are genetically predisposed to develop breast or ovarian cancer. This study examined the relationships between psychological distress and use of BRCA1 testing by 149 high-risk individuals from hereditary cancer families. After a baseline assessment of demographics, objective risk, cancer-specific distress, and global distress (depressive symptoms), study participants were offered the opportunity to receive genetic counseling and to learn whether they carry a mutation in the BRCA1 gene. Overall, 58% of study participants requested BRCA1 test results, and 42% declined to learn their genetic status. After controlling for demographic factors and risk status, cancer-specific distress was significantly and positively related to BRCA1 test use, whereas global distress was unrelated to test use.

AB - The recent identification of BRCA1, a breast cancer susceptibility gene, offers an unprecedented opportunity for high-risk individuals to learn whether they are genetically predisposed to develop breast or ovarian cancer. This study examined the relationships between psychological distress and use of BRCA1 testing by 149 high-risk individuals from hereditary cancer families. After a baseline assessment of demographics, objective risk, cancer-specific distress, and global distress (depressive symptoms), study participants were offered the opportunity to receive genetic counseling and to learn whether they carry a mutation in the BRCA1 gene. Overall, 58% of study participants requested BRCA1 test results, and 42% declined to learn their genetic status. After controlling for demographic factors and risk status, cancer-specific distress was significantly and positively related to BRCA1 test use, whereas global distress was unrelated to test use.

UR - http://www.scopus.com/inward/record.url?scp=0030994277&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030994277&partnerID=8YFLogxK

U2 - 10.1037/0022-006X.65.3.414

DO - 10.1037/0022-006X.65.3.414

M3 - Article

VL - 65

SP - 414

EP - 420

JO - Journal of Consulting and Clinical Psychology

JF - Journal of Consulting and Clinical Psychology

SN - 0022-006X

IS - 3

ER -