Abstract
Women with BRCA1 mutations are at an elevated risk for breast cancer. AIB1 (NCOA3/SRC3) genotype and smoking may alter this risk. We examined the differences in breast cancer risk by AIB1 polyglutamine repeat polymorphism and pre-diagnosis smoking habits for BRCA1 mutation carriers to determine if there was an interaction between smoking and AIB1 genotype. Multivariate Cox proportional hazards regression was used with 316 female BRCA1 mutation carriers to model breast cancer risk. Ever having smoked was associated with a decreased breast cancer risk [Hazard Ratio (HR) = 0.63, 95% CI, 0.47-0.87]. A dose-response relationship between number of pack-years smoked and breast cancer risk was also found for women who smoked
| Original language | English |
|---|---|
| Pages (from-to) | 599-605 |
| Number of pages | 7 |
| Journal | Carcinogenesis |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2006 |
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All Science Journal Classification (ASJC) codes
- Cancer Research
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The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers. / Colilla, Susan; Kantoff, Philip W.; Neuhausen, Susan L.; Godwin, Andrew K.; Daly, Mary B.; Narod, Steven A.; Garber, Judy E.; Lynch, Henry T.; Brown, Myles; Weber, Barbara L.; Rebbeck, Timothy R.
In: Carcinogenesis, Vol. 27, No. 3, 03.2006, p. 599-605.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers
AU - Colilla, Susan
AU - Kantoff, Philip W.
AU - Neuhausen, Susan L.
AU - Godwin, Andrew K.
AU - Daly, Mary B.
AU - Narod, Steven A.
AU - Garber, Judy E.
AU - Lynch, Henry T.
AU - Brown, Myles
AU - Weber, Barbara L.
AU - Rebbeck, Timothy R.
PY - 2006/3
Y1 - 2006/3
N2 - Women with BRCA1 mutations are at an elevated risk for breast cancer. AIB1 (NCOA3/SRC3) genotype and smoking may alter this risk. We examined the differences in breast cancer risk by AIB1 polyglutamine repeat polymorphism and pre-diagnosis smoking habits for BRCA1 mutation carriers to determine if there was an interaction between smoking and AIB1 genotype. Multivariate Cox proportional hazards regression was used with 316 female BRCA1 mutation carriers to model breast cancer risk. Ever having smoked was associated with a decreased breast cancer risk [Hazard Ratio (HR) = 0.63, 95% CI, 0.47-0.87]. A dose-response relationship between number of pack-years smoked and breast cancer risk was also found for women who smoked
AB - Women with BRCA1 mutations are at an elevated risk for breast cancer. AIB1 (NCOA3/SRC3) genotype and smoking may alter this risk. We examined the differences in breast cancer risk by AIB1 polyglutamine repeat polymorphism and pre-diagnosis smoking habits for BRCA1 mutation carriers to determine if there was an interaction between smoking and AIB1 genotype. Multivariate Cox proportional hazards regression was used with 316 female BRCA1 mutation carriers to model breast cancer risk. Ever having smoked was associated with a decreased breast cancer risk [Hazard Ratio (HR) = 0.63, 95% CI, 0.47-0.87]. A dose-response relationship between number of pack-years smoked and breast cancer risk was also found for women who smoked
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U2 - 10.1093/carcin/bgi246
DO - 10.1093/carcin/bgi246
M3 - Article
VL - 27
SP - 599
EP - 605
JO - Carcinogenesis
JF - Carcinogenesis
SN - 0143-3334
IS - 3
ER -