The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers

Susan Colilla, Philip W. Kantoff, Susan L. Neuhausen, Andrew K. Godwin, Mary B. Daly, Steven A. Narod, Judy E. Garber, Henry T. Lynch, Myles Brown, Barbara L. Weber, Timothy R. Rebbeck

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30 Scopus citations

Abstract

Women with BRCA1 mutations are at an elevated risk for breast cancer. AIB1 (NCOA3/SRC3) genotype and smoking may alter this risk. We examined the differences in breast cancer risk by AIB1 polyglutamine repeat polymorphism and pre-diagnosis smoking habits for BRCA1 mutation carriers to determine if there was an interaction between smoking and AIB1 genotype. Multivariate Cox proportional hazards regression was used with 316 female BRCA1 mutation carriers to model breast cancer risk. Ever having smoked was associated with a decreased breast cancer risk [Hazard Ratio (HR) = 0.63, 95% CI, 0.47-0.87]. A dose-response relationship between number of pack-years smoked and breast cancer risk was also found for women who smoked

Original languageEnglish
Pages (from-to)599-605
Number of pages7
JournalCarcinogenesis
Volume27
Issue number3
DOIs
StatePublished - Mar 2006

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All Science Journal Classification (ASJC) codes

  • Cancer Research

Cite this

Colilla, S., Kantoff, P. W., Neuhausen, S. L., Godwin, A. K., Daly, M. B., Narod, S. A., Garber, J. E., Lynch, H. T., Brown, M., Weber, B. L., & Rebbeck, T. R. (2006). The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers. Carcinogenesis, 27(3), 599-605. https://doi.org/10.1093/carcin/bgi246