The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers

Susan Colilla; Philip W. Kantoff; Susan L. Neuhausen; Andrew K. Godwin; Mary B. Daly; Steven A. Narod; Judy E. Garber; Henry T. Lynch; Myles Brown; Barbara L. Weber; Timothy R. Rebbeck

doi:10.1093/carcin/bgi246

The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers

Susan Colilla, Philip W. Kantoff, Susan L. Neuhausen, Andrew K. Godwin, Mary B. Daly, Steven A. Narod, Judy E. Garber, Henry T. Lynch, Myles Brown, Barbara L. Weber, Timothy R. Rebbeck

Department of Preventive Medicine

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Women with BRCA1 mutations are at an elevated risk for breast cancer. AIB1 (NCOA3/SRC3) genotype and smoking may alter this risk. We examined the differences in breast cancer risk by AIB1 polyglutamine repeat polymorphism and pre-diagnosis smoking habits for BRCA1 mutation carriers to determine if there was an interaction between smoking and AIB1 genotype. Multivariate Cox proportional hazards regression was used with 316 female BRCA1 mutation carriers to model breast cancer risk. Ever having smoked was associated with a decreased breast cancer risk [Hazard Ratio (HR) = 0.63, 95% CI, 0.47-0.87]. A dose-response relationship between number of pack-years smoked and breast cancer risk was also found for women who smoked

Original language	English (US)
Pages (from-to)	599-605
Number of pages	7
Journal	Carcinogenesis
Volume	27
Issue number	3
DOIs	https://doi.org/10.1093/carcin/bgi246
State	Published - Mar 2006

All Science Journal Classification (ASJC) codes

Cancer Research

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10.1093/carcin/bgi246

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The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers. / Colilla, Susan; Kantoff, Philip W.; Neuhausen, Susan L.; Godwin, Andrew K.; Daly, Mary B.; Narod, Steven A.; Garber, Judy E.; Lynch, Henry T.; Brown, Myles; Weber, Barbara L.; Rebbeck, Timothy R.

In: Carcinogenesis, Vol. 27, No. 3, 03.2006, p. 599-605.

Research output: Contribution to journal › Article › peer-review

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title = "The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers",

abstract = "Women with BRCA1 mutations are at an elevated risk for breast cancer. AIB1 (NCOA3/SRC3) genotype and smoking may alter this risk. We examined the differences in breast cancer risk by AIB1 polyglutamine repeat polymorphism and pre-diagnosis smoking habits for BRCA1 mutation carriers to determine if there was an interaction between smoking and AIB1 genotype. Multivariate Cox proportional hazards regression was used with 316 female BRCA1 mutation carriers to model breast cancer risk. Ever having smoked was associated with a decreased breast cancer risk [Hazard Ratio (HR) = 0.63, 95% CI, 0.47-0.87]. A dose-response relationship between number of pack-years smoked and breast cancer risk was also found for women who smoked ",

author = "Susan Colilla and Kantoff, {Philip W.} and Neuhausen, {Susan L.} and Godwin, {Andrew K.} and Daly, {Mary B.} and Narod, {Steven A.} and Garber, {Judy E.} and Lynch, {Henry T.} and Myles Brown and Weber, {Barbara L.} and Rebbeck, {Timothy R.}",

note = "Funding Information: Supported by grants from the NIH (T32-CA009679 to SC; R21-ES-011658 to TR and SC; R01-CA83855 and R01-CA102776 to T.R.R.; R01-CA57601 to BLW; R01-CA74415 to S.L.N.), the Abramson Cancer Center (to T.R.R.), the Abramson Family Cancer Research Institute (to B.L.W.), the Breast Cancer Research Foundation (to B.L.W.), the Dana-Farber Women{\textquoteright}s Cancers Program (to J.E.G.), the Department of Defense (DAMD-17-96-I-6088to A.K.G. and DAMD-17-97-I-7112 to H.T.L.), and the Nebraska State Cancer and Smoking-Related Diseases Research Program (LB595 to H.T.L.). Funding to pay the Open Access publication charges for this article was provided by NCI grant R01-CA102776.",

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The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers

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