@article{b071126ac80e4b12b9712ad1cccf2930,
title = "The Ketogenic Diet Increases Mitochondrial Uncoupling Protein Levels and Activity",
abstract = "Fatty acids are known to enhance mitochondrial uncoupling protein (UCP) activity. We asked whether a highfat ketogenic diet (KD) increases UCP levels and activity in hippocampi of juvenile mice. Maximum mitochondrial respiration rates were significantly (p <0.001) higher in KD- versus standard diet (SD)-treated animals, indicating increased UCP-mediated proton conductance that can reduce reactive oxygen species (ROS) production. Western blots showed significant (p <0.05) or borderline significant increases in UCP2, UCP4, and UCP5 protein levels, and increased immunoreactivity to these three UCP isoforms was most prominently seen in the dentate gyrus of KD-fed mice. Finally, we found that oligomycin-induced ROS production was significantly (p <0.05) lower in KD-fed mice than in SD controls. Collectively, our data suggest that a KD may exert neuroprotective effects by diminishing ROS production through activation of mitochondrial UCPs.",
author = "Sullivan, {Patrick G.} and Rippy, {Nancy A.} and Simeone, {Kristina A.} and Concepcion, {Rachele C.} and Agarwal, {Aakash K.} and Rho, {Jong M.}",
year = "2004",
month = "4",
doi = "10.1002/ana.20062",
language = "English",
volume = "55",
pages = "576--580",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "4",
}