The kinetics of urinary fumonisin B1 excretion in humans consuming maize-based diets

Ronald T. Riley, Olga Torres, Jency L. Showker, Nicholas C. Zitomer, Jorge Matute, Kenneth A. Voss, Janee Gelineau-van Waes, Joyce R. Maddox, Simon G. Gregory, Allison E. Ashley-Koch

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Scope: Fumonisins (FB) are mycotoxins found in maize. The purpose of this study was to (i) determine the relationship between FB1, FB2, and FB3 intake and urinary excretion in humans, (ii) validate a method to isolate urinary FB on C18-SPE cartridges for international shipment, and (iii) test the method using samples from Guatemala. Methods and results: Volunteers (n = 10) consumed 206 grams/day of tortillas and biscuits prepared from masa flour and a product containing maize flour. Volunteers estimated their daily urine output and samples were analyzed for FB1, FB2, and FB3 and hydrolyzed FB1. Only FB1 was detected in urine suggesting lower absorption of FB2 and FB3. Excretion was highly variable peaking soon after consumption began and decreasing rapidly after consumption stopped. Within 5 days after consumption ended, FB1 was not detected in urine. In a study with eight volunteers, the average total urinary FB1 was 0.5% of the intake. FB1 was detected in 61% (107/177) of the samples collected in Guatemala. Conclusion: The results support the use of urinary FB1 to assess ongoing exposure in popula-tion-based studies. However, relating the FB1 concentration in urine to dietary intake of FB by individual subjects will be complicated due to interindividual variability and the rapidity of clearance.

Original languageEnglish
Pages (from-to)1445-1455
Number of pages11
JournalMolecular Nutrition and Food Research
Volume56
Issue number9
DOIs
StatePublished - Sep 2012

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fumonisin B1
Zea mays
urine
excretion
Urine
Guatemala
Diet
volunteers
kinetics
Volunteers
corn
Flour
diet
masa
Fumonisins
tortillas
corn flour
biscuits
Mycotoxins
fumonisins

All Science Journal Classification (ASJC) codes

  • Food Science
  • Biotechnology

Cite this

Riley, R. T., Torres, O., Showker, J. L., Zitomer, N. C., Matute, J., Voss, K. A., ... Ashley-Koch, A. E. (2012). The kinetics of urinary fumonisin B1 excretion in humans consuming maize-based diets. Molecular Nutrition and Food Research, 56(9), 1445-1455. https://doi.org/10.1002/mnfr.201200166

The kinetics of urinary fumonisin B1 excretion in humans consuming maize-based diets. / Riley, Ronald T.; Torres, Olga; Showker, Jency L.; Zitomer, Nicholas C.; Matute, Jorge; Voss, Kenneth A.; Gelineau-van Waes, Janee; Maddox, Joyce R.; Gregory, Simon G.; Ashley-Koch, Allison E.

In: Molecular Nutrition and Food Research, Vol. 56, No. 9, 09.2012, p. 1445-1455.

Research output: Contribution to journalArticle

Riley, RT, Torres, O, Showker, JL, Zitomer, NC, Matute, J, Voss, KA, Gelineau-van Waes, J, Maddox, JR, Gregory, SG & Ashley-Koch, AE 2012, 'The kinetics of urinary fumonisin B1 excretion in humans consuming maize-based diets', Molecular Nutrition and Food Research, vol. 56, no. 9, pp. 1445-1455. https://doi.org/10.1002/mnfr.201200166
Riley, Ronald T. ; Torres, Olga ; Showker, Jency L. ; Zitomer, Nicholas C. ; Matute, Jorge ; Voss, Kenneth A. ; Gelineau-van Waes, Janee ; Maddox, Joyce R. ; Gregory, Simon G. ; Ashley-Koch, Allison E. / The kinetics of urinary fumonisin B1 excretion in humans consuming maize-based diets. In: Molecular Nutrition and Food Research. 2012 ; Vol. 56, No. 9. pp. 1445-1455.
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abstract = "Scope: Fumonisins (FB) are mycotoxins found in maize. The purpose of this study was to (i) determine the relationship between FB1, FB2, and FB3 intake and urinary excretion in humans, (ii) validate a method to isolate urinary FB on C18-SPE cartridges for international shipment, and (iii) test the method using samples from Guatemala. Methods and results: Volunteers (n = 10) consumed 206 grams/day of tortillas and biscuits prepared from masa flour and a product containing maize flour. Volunteers estimated their daily urine output and samples were analyzed for FB1, FB2, and FB3 and hydrolyzed FB1. Only FB1 was detected in urine suggesting lower absorption of FB2 and FB3. Excretion was highly variable peaking soon after consumption began and decreasing rapidly after consumption stopped. Within 5 days after consumption ended, FB1 was not detected in urine. In a study with eight volunteers, the average total urinary FB1 was 0.5{\%} of the intake. FB1 was detected in 61{\%} (107/177) of the samples collected in Guatemala. Conclusion: The results support the use of urinary FB1 to assess ongoing exposure in popula-tion-based studies. However, relating the FB1 concentration in urine to dietary intake of FB by individual subjects will be complicated due to interindividual variability and the rapidity of clearance.",
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