Abstract
The ability of the lower esophageal sphincter to protect the esophageal mucosa from exposure to gastric juice depends on its resting pressure, length exposed to abdominal pressure, and overall length. Mechanical incompetency of the sphincter can occur when one or more of these components fail. The purpose of this study was to measure manometrically the normal percentile values for these components, and to identify the point differentiating a mechanically competent from an incompetent sphincter. The results show that a mechanically incompetent sphincter can be identified by a sphincter pressure below the 2.5 percentile, an abdominal length below the fifth percentile, and an overall length below the 2.5 percentile of normal values. Sixty percent of the patients with documented increased esophageal exposure to acid gastric juice had a mechanically incompetent sphincter.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 104-111 |
| Number of pages | 8 |
| Journal | The American Journal of Surgery |
| Volume | 155 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1988 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Surgery
Cite this
The lower esophageal sphincter in health and disease. / Zaninotto, Giovanni; DeMeester, Tom R.; Schwizer, Werner; Johansson, Kari Erik; Cheng, Shih-Chuan.
In: The American Journal of Surgery, Vol. 155, No. 1, 1988, p. 104-111.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The lower esophageal sphincter in health and disease
AU - Zaninotto, Giovanni
AU - DeMeester, Tom R.
AU - Schwizer, Werner
AU - Johansson, Kari Erik
AU - Cheng, Shih-Chuan
PY - 1988
Y1 - 1988
N2 - The ability of the lower esophageal sphincter to protect the esophageal mucosa from exposure to gastric juice depends on its resting pressure, length exposed to abdominal pressure, and overall length. Mechanical incompetency of the sphincter can occur when one or more of these components fail. The purpose of this study was to measure manometrically the normal percentile values for these components, and to identify the point differentiating a mechanically competent from an incompetent sphincter. The results show that a mechanically incompetent sphincter can be identified by a sphincter pressure below the 2.5 percentile, an abdominal length below the fifth percentile, and an overall length below the 2.5 percentile of normal values. Sixty percent of the patients with documented increased esophageal exposure to acid gastric juice had a mechanically incompetent sphincter.
AB - The ability of the lower esophageal sphincter to protect the esophageal mucosa from exposure to gastric juice depends on its resting pressure, length exposed to abdominal pressure, and overall length. Mechanical incompetency of the sphincter can occur when one or more of these components fail. The purpose of this study was to measure manometrically the normal percentile values for these components, and to identify the point differentiating a mechanically competent from an incompetent sphincter. The results show that a mechanically incompetent sphincter can be identified by a sphincter pressure below the 2.5 percentile, an abdominal length below the fifth percentile, and an overall length below the 2.5 percentile of normal values. Sixty percent of the patients with documented increased esophageal exposure to acid gastric juice had a mechanically incompetent sphincter.
UR - http://www.scopus.com/inward/record.url?scp=0023854172&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023854172&partnerID=8YFLogxK
U2 - 10.1016/S0002-9610(88)80266-6
DO - 10.1016/S0002-9610(88)80266-6
M3 - Article
C2 - 3341525
AN - SCOPUS:0023854172
VL - 155
SP - 104
EP - 111
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 1
ER -