The Lynch syndrome

Melding natural history and molecular genetics to genetic counseling and cancer control

Henry T. Lynch, J. F. Lynch

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC), also referred to as Lynch syndromes I and II, is an autosomal, dominantly inherited disorder that accounts for approximately 5% of all colorectal cancers. While colorectal cancer is the most frequently occurring malignancy in HNPCC, other types of cancer occur with increased statistical significance. A better understanding of its natural history, particularly early age of onset and the pattern of multiple primary cancer excess, is essential for the diagnosis and management of HNPCC.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalCancer Control
Volume3
Issue number1
StatePublished - 1996

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Hereditary Nonpolyposis Colorectal Neoplasms
Genetic Counseling
Natural History
Molecular Biology
Lynch Syndrome II
Colorectal Neoplasms
Neoplasms
Age of Onset

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

The Lynch syndrome : Melding natural history and molecular genetics to genetic counseling and cancer control. / Lynch, Henry T.; Lynch, J. F.

In: Cancer Control, Vol. 3, No. 1, 1996, p. 13-19.

Research output: Contribution to journalReview article

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