Abstract
Hereditary nonpolyposis colorectal cancer (HNPCC), also referred to as Lynch syndromes I and II, is an autosomal, dominantly inherited disorder that accounts for approximately 5% of all colorectal cancers. While colorectal cancer is the most frequently occurring malignancy in HNPCC, other types of cancer occur with increased statistical significance. A better understanding of its natural history, particularly early age of onset and the pattern of multiple primary cancer excess, is essential for the diagnosis and management of HNPCC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 13-19 |
| Number of pages | 7 |
| Journal | Cancer Control |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1996 |
All Science Journal Classification (ASJC) codes
- Hematology
- Oncology
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Lynch, H. T., & Lynch, J. F. (1996). The Lynch syndrome: Melding natural history and molecular genetics to genetic counseling and cancer control. Cancer Control, 3(1), 13-19. https://doi.org/10.1177/107327489600300101