The Lynch syndrome: Melding natural history and molecular genetics to genetic counseling and cancer control

H. T. Lynch, J. F. Lynch

Research output: Contribution to journalReview article

10 Scopus citations


Hereditary nonpolyposis colorectal cancer (HNPCC), also referred to as Lynch syndromes I and II, is an autosomal, dominantly inherited disorder that accounts for approximately 5% of all colorectal cancers. While colorectal cancer is the most frequently occurring malignancy in HNPCC, other types of cancer occur with increased statistical significance. A better understanding of its natural history, particularly early age of onset and the pattern of multiple primary cancer excess, is essential for the diagnosis and management of HNPCC.

Original languageEnglish (US)
Pages (from-to)13-19
Number of pages7
JournalCancer Control
Issue number1
StatePublished - Jan 1 1996


All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

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