Abstract
Hereditary nonpolyposis colorectal cancer (HNPCC), also referred to as Lynch syndromes I and II, is an autosomal, dominantly inherited disorder that accounts for approximately 5% of all colorectal cancers. While colorectal cancer is the most frequently occurring malignancy in HNPCC, other types of cancer occur with increased statistical significance. A better understanding of its natural history, particularly early age of onset and the pattern of multiple primary cancer excess, is essential for the diagnosis and management of HNPCC.
| Original language | English |
|---|---|
| Pages (from-to) | 13-19 |
| Number of pages | 7 |
| Journal | Cancer Control |
| Volume | 3 |
| Issue number | 1 |
| State | Published - 1996 |
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All Science Journal Classification (ASJC) codes
- Oncology
Cite this
The Lynch syndrome : Melding natural history and molecular genetics to genetic counseling and cancer control. / Lynch, Henry T.; Lynch, J. F.
In: Cancer Control, Vol. 3, No. 1, 1996, p. 13-19.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The Lynch syndrome
T2 - Melding natural history and molecular genetics to genetic counseling and cancer control
AU - Lynch, Henry T.
AU - Lynch, J. F.
PY - 1996
Y1 - 1996
N2 - Hereditary nonpolyposis colorectal cancer (HNPCC), also referred to as Lynch syndromes I and II, is an autosomal, dominantly inherited disorder that accounts for approximately 5% of all colorectal cancers. While colorectal cancer is the most frequently occurring malignancy in HNPCC, other types of cancer occur with increased statistical significance. A better understanding of its natural history, particularly early age of onset and the pattern of multiple primary cancer excess, is essential for the diagnosis and management of HNPCC.
AB - Hereditary nonpolyposis colorectal cancer (HNPCC), also referred to as Lynch syndromes I and II, is an autosomal, dominantly inherited disorder that accounts for approximately 5% of all colorectal cancers. While colorectal cancer is the most frequently occurring malignancy in HNPCC, other types of cancer occur with increased statistical significance. A better understanding of its natural history, particularly early age of onset and the pattern of multiple primary cancer excess, is essential for the diagnosis and management of HNPCC.
UR - http://www.scopus.com/inward/record.url?scp=0030001611&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030001611&partnerID=8YFLogxK
M3 - Review article
AN - SCOPUS:0030001611
VL - 3
SP - 13
EP - 19
JO - Cancer Control
JF - Cancer Control
SN - 1073-2748
IS - 1
ER -