The Mayo Dysphagia Questionnaire-30: Documentation of reliability and validity of a tool for interventional trials in adults with esophageal disease

Judith McElhiney, Matthew R. Lohse, Amindra S. Arora, Joanna M. Peloquin, Debra M. Geno, Melissa M. Kuntz, Felicity B. Enders, Mary Fredericksen, Adil A. Abdalla, Yulia Khan, Nicholas J. Talley, Nancy N. Diehl, Timothy J. Beebe, Ann M. Harris, Gianrico Farrugia, Darlene E. Graner, Joseph A. Murray, G. Richard Locke, Rayna M. Grothe, Michael D. CrowellDawn L. Francis, April M.B. Grudell, Tushar Dabade, Angelica Ramirez, Mhdmaan Alkhatib, Jeffrey A. Alexander, Jessica Kimber, Ganapathy Prasad, Alan R. Zinsmeister, Yvonne Romero

Research output: Contribution to journalArticle


The aim of this study was to develop the Mayo Dysphagia Questionnaire-30 Day (MDQ-30), a tool to measure esophageal dysphagia, by adapting items from validated instruments for use in clinical trials, and assess its feasibility, reproducibility, and concurrent validity. Outpatients referred to endoscopy for dysphagia or seen in a specialty clinic were recruited. Feasibility testing was done to identify problematic items. Reproducibility was measured by test-retest format. Concurrent validity reflects agreement between information gathered in a structured interview versus the patients' written responses. The MDQ-30, a 28-item instrument, took 10 min (range = 5-30 min) to complete. Four hundred thirty-one outpatients [210 (49%) men; mean age = 61 years] participated. Overall, most concurrent validity κ values for dysphagia were very good to excellent with a median of 0.78 (min 0.28, max 0.95). The majority of reproducibility κ values for dysphagia were moderate to excellent with a median κ value of 0.66 (min 0.07, max 1.0). Overall, concurrent validity and reproducibility κ values for gastroesophageal reflux disease (GERD) symptoms were 0.81 (95% CI = 0.72, 0.91) and 0.66 (95% CI = 0.55, 0.77), respectively. Individual item percent agreement was generally very good to excellent. Internal consistency was excellent. We conclude that the MDQ-30 is an easy-to-complete tool to evaluate reliably dysphagia symptoms over the last 30 days.

Original languageEnglish (US)
Pages (from-to)221-230
Number of pages10
Issue number3
Publication statusPublished - Sep 1 2010
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Gastroenterology
  • Speech and Hearing

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