The molecular basis of neurosensory cell formation in ear development

A blueprint for hair cell and sensory neuron regeneration?

Bernd Fritzsch, Kirk Beisel, Laura A. Hansen

Research output: Contribution to journalReview article

86 Citations (Scopus)

Abstract

The inner ear of mammals uses neurosensory cells derived from the embryonic ear for mechanoelectric transduction of vestibular and auditory stimuli (the hair cells) and conducts this information to the brain via sensory neurons. As with most other neurons of mammals, lost hair cells and sensory neurons are not spontaneously replaced and result instead in age-dependent progressive hearing loss. We review the molecular basis of neurosensory development in the mouse ear to provide a blueprint for possible enhancement of therapeutically useful transformation of stem cells into lost neurosensory cells. We identify several readily available adult sources of stem cells that express, like the ectoderm-derived ear, genes known to be essential for ear development. Use of these stem cells combined with molecular insights into neurosensory cell specification and proliferation regulation of the ear, might allow for neurosensory regeneration of mammalian ears in the near future.

Original languageEnglish
Pages (from-to)1181-1193
Number of pages13
JournalBioEssays
Volume28
Issue number12
DOIs
StatePublished - Dec 2006

Fingerprint

Blueprints
sensory neurons
Sensory Receptor Cells
Stem cells
Neurons
hairs
Ear
Regeneration
ears
Mammals
Cells
stem cells
Audition
cells
Brain
Auditory Hair Cells
Stem Cells
Genes
Specifications
Ectoderm

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology
  • Developmental Biology
  • Neuroscience (miscellaneous)

Cite this

The molecular basis of neurosensory cell formation in ear development : A blueprint for hair cell and sensory neuron regeneration? / Fritzsch, Bernd; Beisel, Kirk; Hansen, Laura A.

In: BioEssays, Vol. 28, No. 12, 12.2006, p. 1181-1193.

Research output: Contribution to journalReview article

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