The muir-torre syndrome: A variant of hereditary nonpolyposis colorectal cancer syndrome

Ramon M. Fusaro, Stephen J. Lemon, Henry T. Lynch

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The Muir-Torre syndrome (MTS) is a variant of the hereditary nonpolyposis colorectal cancer syndrome (HNPCC). The MTS has to be redefined clinically to include all the potential cutaneous phenotypes of sebaceous neoplasms including keratoacanthoma as the latter, MTS and HNPCC have all been identified with the genetic molecular findings of chromosomal abnormalities of DNA mismatched repair (MMR) sequences. Retrospective pedigree investigations for systemic cancer occurrences and cutaneous stigmata of MTS, followed by gene testing for abnormal DNA MMR, will identify kindreds and their members with high hereditary cancer risks for HNPCC.

Original languageEnglish (US)
Pages (from-to)19-27
Number of pages9
JournalJournal of Tumor Marker Oncology
Volume11
Issue number1
StatePublished - Dec 1 1996

All Science Journal Classification (ASJC) codes

  • Cancer Research

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