The muir-torre syndrome

A variant of hereditary nonpolyposis colorectal cancer syndrome

Ramon M. Fusaro, Stephen J. Lemon, Henry T. Lynch

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The Muir-Torre syndrome (MTS) is a variant of the hereditary nonpolyposis colorectal cancer syndrome (HNPCC). The MTS has to be redefined clinically to include all the potential cutaneous phenotypes of sebaceous neoplasms including keratoacanthoma as the latter, MTS and HNPCC have all been identified with the genetic molecular findings of chromosomal abnormalities of DNA mismatched repair (MMR) sequences. Retrospective pedigree investigations for systemic cancer occurrences and cutaneous stigmata of MTS, followed by gene testing for abnormal DNA MMR, will identify kindreds and their members with high hereditary cancer risks for HNPCC.

Original languageEnglish
Pages (from-to)19-27
Number of pages9
JournalJournal of Tumor Marker Oncology
Volume11
Issue number1
StatePublished - 1996

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Muir-Torre Syndrome
Hereditary Nonpolyposis Colorectal Neoplasms
DNA Repair
Keratoacanthoma
Christianity
Skin Neoplasms
Pedigree
Chromosome Aberrations
Molecular Biology
Neoplasms
Phenotype
Skin
Genes

All Science Journal Classification (ASJC) codes

  • Cancer Research

Cite this

The muir-torre syndrome : A variant of hereditary nonpolyposis colorectal cancer syndrome. / Fusaro, Ramon M.; Lemon, Stephen J.; Lynch, Henry T.

In: Journal of Tumor Marker Oncology, Vol. 11, No. 1, 1996, p. 19-27.

Research output: Contribution to journalArticle

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