Abstract
The Muir-Torre syndrome (MTS) is a variant of the hereditary nonpolyposis colorectal cancer syndrome (HNPCC). The MTS has to be redefined clinically to include all the potential cutaneous phenotypes of sebaceous neoplasms including keratoacanthoma as the latter, MTS and HNPCC have all been identified with the genetic molecular findings of chromosomal abnormalities of DNA mismatched repair (MMR) sequences. Retrospective pedigree investigations for systemic cancer occurrences and cutaneous stigmata of MTS, followed by gene testing for abnormal DNA MMR, will identify kindreds and their members with high hereditary cancer risks for HNPCC.
| Original language | English |
|---|---|
| Pages (from-to) | 19-27 |
| Number of pages | 9 |
| Journal | Journal of Tumor Marker Oncology |
| Volume | 11 |
| Issue number | 1 |
| State | Published - 1996 |
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All Science Journal Classification (ASJC) codes
- Cancer Research
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The muir-torre syndrome : A variant of hereditary nonpolyposis colorectal cancer syndrome. / Fusaro, Ramon M.; Lemon, Stephen J.; Lynch, Henry T.
In: Journal of Tumor Marker Oncology, Vol. 11, No. 1, 1996, p. 19-27.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The muir-torre syndrome
T2 - A variant of hereditary nonpolyposis colorectal cancer syndrome
AU - Fusaro, Ramon M.
AU - Lemon, Stephen J.
AU - Lynch, Henry T.
PY - 1996
Y1 - 1996
N2 - The Muir-Torre syndrome (MTS) is a variant of the hereditary nonpolyposis colorectal cancer syndrome (HNPCC). The MTS has to be redefined clinically to include all the potential cutaneous phenotypes of sebaceous neoplasms including keratoacanthoma as the latter, MTS and HNPCC have all been identified with the genetic molecular findings of chromosomal abnormalities of DNA mismatched repair (MMR) sequences. Retrospective pedigree investigations for systemic cancer occurrences and cutaneous stigmata of MTS, followed by gene testing for abnormal DNA MMR, will identify kindreds and their members with high hereditary cancer risks for HNPCC.
AB - The Muir-Torre syndrome (MTS) is a variant of the hereditary nonpolyposis colorectal cancer syndrome (HNPCC). The MTS has to be redefined clinically to include all the potential cutaneous phenotypes of sebaceous neoplasms including keratoacanthoma as the latter, MTS and HNPCC have all been identified with the genetic molecular findings of chromosomal abnormalities of DNA mismatched repair (MMR) sequences. Retrospective pedigree investigations for systemic cancer occurrences and cutaneous stigmata of MTS, followed by gene testing for abnormal DNA MMR, will identify kindreds and their members with high hereditary cancer risks for HNPCC.
UR - http://www.scopus.com/inward/record.url?scp=0002583142&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0002583142&partnerID=8YFLogxK
M3 - Article
VL - 11
SP - 19
EP - 27
JO - Journal of Tumor Marker Oncology
JF - Journal of Tumor Marker Oncology
SN - 0886-3849
IS - 1
ER -