The NF-κB-Responsive long noncoding RNA FIRRE regulates posttranscriptional regulation of inflammatory gene expression through interacting with hnRNPU

Yajing Lu, Xu Liu, Minghong Xie, Mingjia Liu, Mengling Ye, Mingxuan Li, Xian-Ming Chen, Xiaoqing Li, Rui Zhou

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Abstract

Long noncoding RNAs, a newly identified class of noncoding RNAs, are important regulators of gene expression in innate immunity. We report in this study that the transcription of FIRRE, a conserved long noncoding RNA between humans and mice, is controlled by NF-κB signaling in macrophages and intestinal epithelial cells. Functionally, FIRRE appears to positively regulate the expression of several inflammatory genes in macrophages or intestinal epithelial cells in response to LPS stimulation via posttranscriptional mechanisms. Specifically, FIRRE physically interacts with heterogeneous nuclear ribonucleoproteins U, regulating the stability of mRNAs of selected inflammatory genes through targeting the AU-rich elements of their mRNAs in cells following LPS stimulation. Therefore, our data indicate a new regulatory role for NF-κB-responsive FIRRE in the posttranscriptional regulation of inflammatory genes in the innate immune system.

Original languageEnglish (US)
Pages (from-to)3571-3582
Number of pages12
JournalJournal of Immunology
Volume199
Issue number10
DOIs
StatePublished - Nov 15 2017

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All Science Journal Classification (ASJC) codes

  • Immunology

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