TY - JOUR
T1 - The NF-κB-Responsive long noncoding RNA FIRRE regulates posttranscriptional regulation of inflammatory gene expression through interacting with hnRNPU
AU - Lu, Yajing
AU - Liu, Xu
AU - Xie, Minghong
AU - Liu, Mingjia
AU - Ye, Mengling
AU - Li, Mingxuan
AU - Chen, Xian Ming
AU - Li, Xiaoqing
AU - Zhou, Rui
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (Grants 31300744 and 81373132) and the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant 20130141120011).
Publisher Copyright:
Copyright © 2017 by The American Association of Immunologists, Inc.
PY - 2017/11/15
Y1 - 2017/11/15
N2 - Long noncoding RNAs, a newly identified class of noncoding RNAs, are important regulators of gene expression in innate immunity. We report in this study that the transcription of FIRRE, a conserved long noncoding RNA between humans and mice, is controlled by NF-κB signaling in macrophages and intestinal epithelial cells. Functionally, FIRRE appears to positively regulate the expression of several inflammatory genes in macrophages or intestinal epithelial cells in response to LPS stimulation via posttranscriptional mechanisms. Specifically, FIRRE physically interacts with heterogeneous nuclear ribonucleoproteins U, regulating the stability of mRNAs of selected inflammatory genes through targeting the AU-rich elements of their mRNAs in cells following LPS stimulation. Therefore, our data indicate a new regulatory role for NF-κB-responsive FIRRE in the posttranscriptional regulation of inflammatory genes in the innate immune system.
AB - Long noncoding RNAs, a newly identified class of noncoding RNAs, are important regulators of gene expression in innate immunity. We report in this study that the transcription of FIRRE, a conserved long noncoding RNA between humans and mice, is controlled by NF-κB signaling in macrophages and intestinal epithelial cells. Functionally, FIRRE appears to positively regulate the expression of several inflammatory genes in macrophages or intestinal epithelial cells in response to LPS stimulation via posttranscriptional mechanisms. Specifically, FIRRE physically interacts with heterogeneous nuclear ribonucleoproteins U, regulating the stability of mRNAs of selected inflammatory genes through targeting the AU-rich elements of their mRNAs in cells following LPS stimulation. Therefore, our data indicate a new regulatory role for NF-κB-responsive FIRRE in the posttranscriptional regulation of inflammatory genes in the innate immune system.
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U2 - 10.4049/jimmunol.1700091
DO - 10.4049/jimmunol.1700091
M3 - Article
C2 - 28993514
AN - SCOPUS:85033400765
VL - 199
SP - 3571
EP - 3582
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 10
ER -