TY - JOUR
T1 - The pancreas and COVID-19
T2 - A clinical conundrum
AU - Goyal, Hemant
AU - Kopel, Jonathan
AU - Ristić, Bojana
AU - Perisetti, Abhilash
AU - Anastasiou, Jiannis
AU - Chandan, Saurabh
AU - Tharian, Benjamin
AU - Inamdar, Sumant
N1 - Publisher Copyright:
© 2021 E-Century Publishing Corporation. All rights reserved.
PY - 2021
Y1 - 2021
N2 - With the progression of the COVID-19 pandemic, the classic manifestations of COVID-19 (e.g., persistent fever, dry cough, pneumonia, and acute respiratory distress syndrome in the severe disease) have expanded to include less common complications of the extrapulmonary organs. Recent evidence has shown that COVID-19 patients with concomitant presence of GI symptoms are at higher risk of developing severe disease and have poor clinical outcomes. Recently, multiple SARS-CoV-2-induced acute pancreatitis (AP) cases have been reported. This literature review aims to provide an insight into SARS-CoV-2-directed invasion of the pancreas. We will also review the currently available literature on the clinical effects of SARS-CoV-2, including AP and mild elevation of lipase levels in patients with COVID-19. In addition, we will discuss plausible mechanisms that underly SARS-CoV-2-induced pancreatitis.
AB - With the progression of the COVID-19 pandemic, the classic manifestations of COVID-19 (e.g., persistent fever, dry cough, pneumonia, and acute respiratory distress syndrome in the severe disease) have expanded to include less common complications of the extrapulmonary organs. Recent evidence has shown that COVID-19 patients with concomitant presence of GI symptoms are at higher risk of developing severe disease and have poor clinical outcomes. Recently, multiple SARS-CoV-2-induced acute pancreatitis (AP) cases have been reported. This literature review aims to provide an insight into SARS-CoV-2-directed invasion of the pancreas. We will also review the currently available literature on the clinical effects of SARS-CoV-2, including AP and mild elevation of lipase levels in patients with COVID-19. In addition, we will discuss plausible mechanisms that underly SARS-CoV-2-induced pancreatitis.
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M3 - Review article
AN - SCOPUS:85118312430
VL - 13
SP - 11004
EP - 11013
JO - American Journal of Translational Research
JF - American Journal of Translational Research
SN - 1943-8141
IS - 10
ER -