The pancreas and COVID-19: A clinical conundrum

Hemant Goyal, Jonathan Kopel, Bojana Ristić, Abhilash Perisetti, Jiannis Anastasiou, Saurabh Chandan, Benjamin Tharian, Sumant Inamdar

Research output: Contribution to journalReview articlepeer-review

Abstract

With the progression of the COVID-19 pandemic, the classic manifestations of COVID-19 (e.g., persistent fever, dry cough, pneumonia, and acute respiratory distress syndrome in the severe disease) have expanded to include less common complications of the extrapulmonary organs. Recent evidence has shown that COVID-19 patients with concomitant presence of GI symptoms are at higher risk of developing severe disease and have poor clinical outcomes. Recently, multiple SARS-CoV-2-induced acute pancreatitis (AP) cases have been reported. This literature review aims to provide an insight into SARS-CoV-2-directed invasion of the pancreas. We will also review the currently available literature on the clinical effects of SARS-CoV-2, including AP and mild elevation of lipase levels in patients with COVID-19. In addition, we will discuss plausible mechanisms that underly SARS-CoV-2-induced pancreatitis.

Original languageEnglish (US)
Pages (from-to)11004-11013
Number of pages10
JournalAmerican Journal of Translational Research
Volume13
Issue number10
StatePublished - 2021

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Clinical Biochemistry
  • Cancer Research

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